1H HR-MAS NMR Based Metabolic Profiling of Lung Cancer Cells with Induced and De-Induced Cisplatin Resistance to Reveal Metabolic Resistance Adaptations

Autor: Martina Vermathen, Hendrik von Tengg-Kobligk, Martin Nils Hungerbühler, Peter Vermathen, Nico Ruprecht

Publikováno v: Molecules, Vol 26, Iss 22, p 6766 (2021)

Cisplatin (cisPt) is an important drug that is used against various cancers, including advanced lung cancer. However, drug resistance is still a major ongoing problem and its investigation is of paramount interest. Here, a high-resolution magic angle

Externí odkaz: https://doaj.org/article/cc18b6b72226465cb564fa292e25efdd

Conjugates Containing Two and Three Trithiolato-Bridged Dinuclear Ruthenium(II)-Arene Units as In Vitro Antiparasitic and Anticancer Agents

Autor: Valentin Studer, Nicoleta Anghel, Oksana Desiatkina, Timo Felder, Ghalia Boubaker, Yosra Amdouni, Jessica Ramseier, Martin Hungerbühler, Christoph Kempf, Johannes Thomas Heverhagen, Andrew Hemphill, Nico Ruprecht, Julien Furrer, Emilia Păunescu

Publikováno v: Pharmaceuticals, Vol 13, Iss 12, p 471 (2020)

The synthesis, characterization, and in vitro antiparasitic and anticancer activity evaluation of new conjugates containing two and three dinuclear trithiolato-bridged ruthenium(II)-arene units are presented. Antiparasitic activity was evaluated usin

Externí odkaz: https://doaj.org/article/0803c7c56b0e4edcba3be599c414f089

Parvovirus B19 Uncoating Occurs in the Cytoplasm without Capsid Disassembly and It Is Facilitated by Depletion of Capsid-Associated Divalent Cations

Autor: Oliver Caliaro, Andrea Marti, Nico Ruprecht, Remo Leisi, Suriyasri Subramanian, Susan Hafenstein, Carlos Ros

Publikováno v: Viruses, Vol 11, Iss 5, p 430 (2019)

Human parvovirus B19 (B19V) traffics to the cell nucleus where it delivers the genome for replication. The intracellular compartment where uncoating takes place, the required capsid structural rearrangements and the cellular factors involved remain u

Externí odkaz: https://doaj.org/article/1aca53a278af460292c9f8d6322ce292

Improved identification of DNA double strand breaks: γ-H2AX-epitope visualization by confocal microscopy and 3D reconstructed images

Autor: Martin Hungerbühler, Johannes T. Heverhagen, Nico Ruprecht, Ingrid Böhm

Publikováno v: Ruprecht, Nico; Hungerbuehler, Martin; Böhm, Ingrid; Heverhagen, Johannes (2019). Improved identification of DNA double strand breaks: γ-H2AX-epitope visualization by confocal microscopy and 3D reconstructed images. Radiation and environmental biophysics, 58(2), pp. 295-302. Springer 10.1007/s00411-019-00778-1

Currently, in the context of radiology, irradiation-induced and other genotoxic effects are determined by visualizing DSB-induced DNA repair through γ-H2AX immunofluorescence and direct counting of the foci by epifluorescence microscopy. This proced

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::433acc0ee2ef424d67a4cc8b8a1f433a
https://doi.org/10.1007/s00411-019-00778-1

Conjugates Containing Two and Three Trithiolato-Bridged Dinuclear Ruthenium(II)-Arene Units as In Vitro Antiparasitic and Anticancer Agents

Autor: Andrew Hemphill, Yosra Amdouni, Jessica Ramseier, Julien Furrer, Martin Hungerbühler, Nicoleta Anghel, Timo Felder, Valentin Studer, Oksana Desiatkina, Johannes T. Heverhagen, Ghalia Boubaker, Nico Ruprecht, Emilia Păunescu, Christoph Kempf

Publikováno v: Pharmaceuticals
Volume 13
Issue 12
Pharmaceuticals, Vol 13, Iss 471, p 471 (2020)
Studer, Valentin; Anghel, Nicoleta; Desiatkina, Oksana; Felder, Timo; Boubaker, Ghalia; Amdouni, Yosra; Ramseier, Jessica; Hungerbühler, Martin; Kempf, Christoph; Heverhagen, Johannes Thomas; Hemphill, Andrew; Ruprecht, Nico; Furrer, Julien; Păunescu, Emilia (2020). Conjugates Containing Two and Three Trithiolato-Bridged Dinuclear Ruthenium(II)-Arene Units as In Vitro Antiparasitic and Anticancer Agents. Pharmaceuticals, 13(12), p. 471. MDPI 10.3390/ph13120471

The synthesis, characterization, and in vitro antiparasitic and anticancer activity evaluation of new conjugates containing two and three dinuclear trithiolato-bridged ruthenium(II)-arene units are presented. Antiparasitic activity was evaluated usin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efddfe54d644bdc319cbbade8aa82e35