Zobrazeno 1 - 10 of 11 pro vyhledávání: '"Nico Michel"'
1
The HIV-1 Pathogenicity Factor Nef Interferes with Maturation of Stimulatory T-lymphocyte Contacts by Modulation of N-Wasp Activity
Autor: Nico Michel, Oliver T. Keppler, Sebastian Hannemann, Oliver T. Fackler, Claudia Haller, Susanne Rauch, Maik J. Lehmann
Publikováno v: Journal of Biological Chemistry. 281:19618-19630
The Nef protein is a key determinant of human immunodeficiency virus (HIV) pathogenicity that, among other activities, sensitizes T-lymphocytes for optimal virus production. The initial events by which Nef modulates the T-cell receptor (TCR) cascade
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::667221f4b4a007ef4b2f448929f48f92
https://doi.org/10.1074/jbc.m513802200
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2
Contents Vol. 45, 2002
Autor: Colin R. Howard, A. Chatterji, Åke Lundkvist, Shereen El Kholy, C. Porta, A. Žvirblienė, Andrea Jegerlehner, Rolf E. Streeck, Stephen Norley, T. Lin, Peter Öhlschläger, Christian Pitra, Jeremy C. Simpson, Detlev H. Krüger, Patrik Maurer, Jörg Reimann, J. Staniulis, Reinhard Kurth, Matthias T. Dittmar, Matti Sällberg, Andris Kazaks, Jonas Kneser, Sylvie Lachmann, Carol A. Roneker, Brent E. Korba, G.P. Lomonossoff, Brian Hjelle, Andris Dislers, L.L. Burns, Eva-Jasmin Freyschmidt, Petra Riedl, Alain Tissot, David R. Milich, Hae-Wol Cho, Marcin Kwissa, Michael Nassal, D.W.G. Brown, J.E. Johnson, S. Süle, James Brooke Murray, Volker Bruss, A. Hale, Angela Rösen-Wolff, K. Sasnauskas, J. Michael Lord, Maurice R. Hilleman, Oliver Hohn, Diana Koletzki, R. Ulrich, Heidrun Guthöhrlein, Brigitte Beer, Wolfram Osen, Ivars Petrovskis, Shahryar Khattak, Lutz Gissmann, Franziska Lechner, Reinhold Schirmbeck, Gary T. Jennings, Hans Gelderblom, W.A. Knowles, A. Dargevičiūte, Jens Wild, Wolfgang A. Renner, Peter G. Stockley, Helga Meisel, Paul J. Cote, Ronald K. Potkul, W. Martin Kast, Velta Ose, Tom R. Phillips, D. Bartkevičiūte, Janice Hughes, Min Wu, Martin F. Bachmann, Peter Sebbel, Erik Seibold, Rainer G. Ulrich, S.S. Taylor, Doris Binninger-Schinzel, Ludwig Deml, Andrew W. Taylor-Robinson, Martin Müller, Paul Pumpens, Chris J. Adams, Ralf Wagner, Hans-Georg Kräusslich, Andreas M. Kaufmann, Robert Allan Mastico, Dörte Radke, Alexandra Bojak, Christophe Hourioux, Ulrich Marcus, Karen G. Heal, Joyce Jones, Mark T. Wakabayashi, Elmars Grens, Corina Cosma, L. Jin, George P. Lomonossoff, Dace Skrastina, Ho-Wang Lee, Stephan Menne, Galina Borisova, Bud C. Tennant, Diane M. Da Silva, William L. Brown, A. Bulavaite, Gholamreza Darai, Thorsten U. Vogel, Nico Michel, John L. Gerin, A. Gedvilaite
Publikováno v: Intervirology. 45:387-389
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ddc9c5708247dd1a35fde974cf4cb774
https://doi.org/10.1159/000069063
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3
Human cyclin T1 expression ameliorates a T-cell-specific transcriptional limitation for HIV in transgenic rats, but is not sufficient for a spreading infection of prototypic R5 HIV-1 strains ex vivo
Autor: Kerstin Ganter, Mohammed Saifuddin, Nico Michel, Oliver T. Keppler, Vineet N. KewalRamani, Christine Goffinet, Dan R. Littman, Warner C. Greene, Ina Allespach, Mark A. Goldsmith
Publikováno v: Retrovirology
Retrovirology, Vol 6, Iss 1, p 2 (2009)
Background Cells derived from native rodents have limits at distinct steps of HIV replication. Rat primary CD4 T-cells, but not macrophages, display a profound transcriptional deficit that is ameliorated by transient trans-complementation with the hu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d79f877cc5c2032fac0c1c7ce439dba5
https://doi.org/10.1186/1742-4690-6-2
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5
Primary T-cells from human CD4/CCR5-transgenic rats support all early steps of HIV-1 replication including integration, but display impaired viral gene expression
Autor: Hanna-Mari Tervo, Nico Michel, Oliver T. Keppler, Hans-Georg Kräusslich, Warner C. Greene, Volker Hermann, Christine Goffinet, Ina Allespach
Publikováno v: Retrovirology, Vol 4, Iss 1, p 53 (2007)
Retrovirology
Background In vivo studies on HIV-1 pathogenesis and testing of antiviral strategies have been hampered by the lack of an immunocompetent small animal model that is highly susceptible to HIV-1 infection. Since native rodents are non-permissive, we de
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7943850896ac880dc59d166b29e125e5
http://www.retrovirology.com/content/4/1/53
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7
The Nef protein of human immunodeficiency virus is a broad-spectrum modulator of chemokine receptor cell surface levels that acts independently of classical motifs for receptor endocytosis and Galphai signaling
Autor: Nico Michel, Oliver T. Keppler, Stephanie Venzke, Julia Bitzegeio, Kerstin Ganter, Oliver T. Fackler
Publikováno v: Molecular biology of the cell. 17(8)
Chemokine receptors (CKRs) are important physiological mediators of immune defense, inflammatory responses, and angiogenesis, and they have also been implicated in a number of viral disease processes. Here, we report that the Nef protein of human imm
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0ca6bafc276074d5d6a7010440c887c
https://pubmed.ncbi.nlm.nih.gov/16775006
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8
The Nef protein of human immunodeficiency virus establishes superinfection immunity by a dual strategy to downregulate cell-surface CCR5 and CD4
Autor: Oliver T. Fackler, Stephanie Venzke, Nico Michel, Oliver T. Keppler, Ina Allespach
Publikováno v: Current biology : CB. 15(8)
Summary Background : Viruses frequently render cells refractory to subsequent infection with the same virus. This state of superinfection immunity counteracts potentially detrimental consequences for the infected cell and facilitates high-level repli
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd08912df9ef471f9a5ff7f7537e8348
https://pubmed.ncbi.nlm.nih.gov/15854903
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9
Enhanced immunogenicity of HPV 16 E7 fusion proteins in DNA vaccination
Autor: Wolfram Osen, Ton N. Schumacher, Hanswalter Zentgraf, Martin Müller, Lutz Gissmann, Nico Michel
Publikováno v: Virology. 294(1)
DNA vaccination is a promising approach for inducing both humoral and cellular immune responses. For immunotherapy of HPV-16-associated diseases the E7 protein is considered a prime candidate, as it is expressed in all HPV-16-positive tumors. Unfortu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eaff3fb839ed7cffe1fe40e76058711
https://pubmed.ncbi.nlm.nih.gov/11886264
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10
A DNA vaccine based on a shuffled E7 oncogene of the human papillomavirus type 16 (HPV 16) induces E7-specific cytotoxic T cells but lacks transforming activity
Autor: Massimo Tommasino, Sandra Caldeira, Stefan Faath, Wolfram Osen, Tanja Peiler, Martin Müller, Peter Öhlschläger, Nico Michel, Lutz Gissmann, Ingrid Jochmus
Publikováno v: Europe PubMed Central
Vaccination with oncogene-derived DNA for anti-cancer treatment carries a risk of de-novo tumor induction triggered by the persisting recombinant DNA. We hypothesized that an oncoprotein whose primary sequence has been rearranged (‘shuffled’) to
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d75b85e0f296b97b928f9103368c441a
https://pubmed.ncbi.nlm.nih.gov/11457555
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