Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Nico Mertens"'
Autor:
Guido Slegers, Filip De Vos, Nico Mertens, Claude Cuvelier, Marleen Praet, Jacques Van Huysse, Lieve Vanwalleghem, Elisabeth Coene, Caroline Dumolyn, Liesbet Vervoort, Steve Schoonooghe, Ingrid Burvenich
This study identifies and characterizes the antigen recognized by monoclonal antibody (mAb) 14C5. We compared the expression of antigen 14C5 with the expression of eight integrin subunits (α1, α2, α3, αv, β1, β2, β3, and β4) and three integri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ad766ec4d845a3c96b9cd5164ef2ba8
https://doi.org/10.1158/1535-7163.c.6531183
https://doi.org/10.1158/1535-7163.c.6531183
Autor:
Guido Slegers, Filip De Vos, Nico Mertens, Claude Cuvelier, Marleen Praet, Jacques Van Huysse, Lieve Vanwalleghem, Elisabeth Coene, Caroline Dumolyn, Liesbet Vervoort, Steve Schoonooghe, Ingrid Burvenich
Supplementary Fig. S1 from Monoclonal antibody 14C5 targets integrin αvβ5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::159fbaf8b74f3668fd74b3bfa3a0139c
https://doi.org/10.1158/1535-7163.22483620.v1
https://doi.org/10.1158/1535-7163.22483620.v1
Autor:
Fumitake Takizawa, Kotaro Yamamoto, Koji Nakamura, Ana R. Richard, Philip J. Cunnah, Nico Mertens, Pedro D. Pissarra, Yukihito Tsukumo
Publikováno v:
Cancer Research. 83:2937-2937
5T4 oncofetal tumor-associated antigen (also known as TPGB or WAIF1) is over-expressed in a wide range of solid tumors but shows very limited expression in normal adult tissues thus suggesting 5T4 as an attractive target for antibody therapy. CBA-153
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38a4a8b1c8c7a2bfe2bb9628aa830c5a
https://doi.org/10.1158/1538-7445.am2023-2937
https://doi.org/10.1158/1538-7445.am2023-2937
T-cell Activating Tribodies as a Novel Approach for Efficient Killing of ErbB2-positive Cancer Cells
Autor:
Gennaro Riccio, Valentina Rubino, Margherita Passariello, Ana Rita Da Fonseca Ricardo, Claudia De Lorenzo, Kathy Saraiva, Nico Mertens, Philip Cunnah
Publikováno v:
Journal of immunotherapy (Hagerstown, Md. : 1997). 42(1)
The Tyrosine Kinase Receptor ErbB2 (HER2) when overexpressed in breast cancer (BC) is associated with poor prognosis. The monoclonal antibody Trastuzumab has become a standard treatment of ErbB2+BC. The antibody treatment has limited efficacy, often
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acef4950fb9a448e08e3602b9f818cc3
https://pubmed.ncbi.nlm.nih.gov/30520849
https://pubmed.ncbi.nlm.nih.gov/30520849
Autor:
Margherita Passariello, Philip Cunnah, Claudia De Lorenzo, Ana R. Da Fonseca-Ricardo, Nico Mertens, Gennaro Riccio
Publikováno v:
Journal of immunotherapy (Hagerstown, Md. : 1997). 40(4)
Downregulation of the epidermal growth factor receptor family of receptors is improved by combining different antibodies to noncompetitive epitopes. For ErbB2/HER2 this has already been translated into clinical practice by using a combination of tras
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca285164929f7a87bcae8cecb06c4ab0
https://pubmed.ncbi.nlm.nih.gov/28125512
https://pubmed.ncbi.nlm.nih.gov/28125512
Autor:
Steve Schoonooghe, Elisabeth Coene, Guido Slegers, Bart Cornelissen, Nico Mertens, Peter Blanckaert, Claude Cuvelier, Ingrid Burvenich
Purpose: The monoclonal antibody (mAb) 14C5 is a murine IgG1 directed against a yet undefined molecule involved in cell substrate adhesion found on the surface of malignant breast cancer tissue. mAb 14C5 is able to inhibit cell substrate adhesion and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46ca9c0270745aa1ebaecd919186a8b8
https://ora.ox.ac.uk/objects/uuid:77555ab4-79d8-4115-bbf1-044bb4922b8f
https://ora.ox.ac.uk/objects/uuid:77555ab4-79d8-4115-bbf1-044bb4922b8f
Autor:
Filip De Vos, Liesbet Vervoort, Steve Schoonooghe, Ingrid Burvenich, Johan Grooten, Nico Mertens
Publikováno v:
Protein Engineering Design and Selection. 23:721-728
Most adenocarcinomas express altered MUC1 as a tumour-associated antigen. Due to suboptimal glycosylation in tumour-associated MUC1, the apomucin core is exposed, revealing new epitopes for antibody-directed immunotherapy. The human PH1 Fab binds spe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f9cedb8570b1c181985f65e29cc2ad0
https://doi.org/10.1093/protein/gzq044
https://doi.org/10.1093/protein/gzq044
Autor:
Guido Slegers, Marleen Praet, Elisabeth Coene, Steve Schoonooghe, Nico Mertens, Ingrid Burvenich, Jacques Van Huysse, Lieve Vanwalleghem, Caroline Dumolyn, Filip De Vos, Liesbet Vervoort, Claude Cuvelier
Publikováno v:
Molecular Cancer Therapeutics. 7:3771-3779
This study identifies and characterizes the antigen recognized by monoclonal antibody (mAb) 14C5. We compared the expression of antigen 14C5 with the expression of eight integrin subunits (α1, α2, α3, αv, β1, β2, β3, and β4) and three integri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f794a9eff638c49e0510b31376006db2
https://doi.org/10.1158/1535-7163.mct-08-0600
https://doi.org/10.1158/1535-7163.mct-08-0600
Autor:
L. Ferdinande, B. G. De Geest, Wim E. Hennink, S. De Koker, Claude Cuvelier, S.C. De Smedt, Nico Mertens, W. Deckers
Publikováno v:
Advanced Functional Materials. 17:3754-3763
Polyelectrolyte microcapsules are made by layer-by-layer (LbL) coating of a sacrificial template, followed by decomposition of the template, to produce hollow microcapsules. In this paper, we report on the in vivo cellular uptake, degradation and bio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba704a6c4068d7d7c3eb28dd033f6f32
https://doi.org/10.1002/adfm.200700416
https://doi.org/10.1002/adfm.200700416
Autor:
Johan Grooten, Filip Devos, Christophe Van de Wiele, Steve Schoonooghe, Stefaan De Koker, Ingrid Burvenich, Dominique Vlieghe, Jannick Leoen, An Willems, Nico Mertens, Els Van Deynse, Andrew G. Kelly
Publikováno v:
Cancer Biotherapy and Radiopharmaceuticals. 19:99-109
The synthesis of radioligands can benefit considerably from optimized recombinant protein production, both on the aspect of economy of production and on the level of improving the targeting and pharmacokinetics of the ligand. This paper first describ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a590baf1bd78c6b787b8ae67bd8ee36
https://doi.org/10.1089/108497804773391748
https://doi.org/10.1089/108497804773391748