S-Ketamine Mediates Its Acute and Sustained Antidepressant-Like Activity through a 5-HT1B Receptor Dependent Mechanism in a Genetic Rat Model of Depression

Autor: Kristian G. du Jardin, Nico Liebenberg, Manuel Cajina, Heidi K. Müller, Betina Elfving, Connie Sanchez, Gregers Wegener

Publikováno v: Frontiers in Pharmacology, Vol 8 (2018)

Rationale: The mechanisms responsible for the unique antidepressant properties of ketamine have only been partly resolved. Recent preclinical reports implicate the neurotransmitter serotonin [5-hydroxytryptamine (5-HT)] in the antidepressant-like res

Externí odkaz: https://doaj.org/article/5b55b38e836d47e39f3023b4b268d0c0

Single dose S-ketamine rescues transcriptional dysregulation of Mtor and Nrp2 in the prefrontal cortex of FSL rats 1hour but not 14 days post dosing

Autor: Betina Elfving, Nico Liebenberg, Kristian du Jardin, Connie Sanchez, Gregers Wegener, Heidi Kaastrup Müller

Publikováno v: Elfving, B, Liebenberg, N, du Jardin, K, Sanchez, C, Wegener, G & Müller, H K 2022, ' Single dose S-ketamine rescues transcriptional dysregulation of Mtor and Nrp2 in the prefrontal cortex of FSL rats 1hour but not 14 days post dosing ', European Neuropsychopharmacology, vol. 65, pp. 56-67 . https://doi.org/10.1016/j.euroneuro.2022.10.011

There is a pressing need to identify biological indicators of major depression to help guide proper diagnosis and optimize treatment. Animal models mimicking aspects of depression constitute essential tools for early-stage exploration of relevant pat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8e0da3ed3b3598a0e4a70b0253d7553
https://pure.au.dk/portal/da/publications/single-dose-sketamine-rescues-transcriptional-dysregulation-of-mtor-and-nrp2-in-the-prefrontal-cortex-of-fsl-rats-1hour-but-not-14-days-post-dosing(3710c0fa-e71f-4f70-9e9a-da1a34bee58c).html

Reduced Brd1 expression leads to reversible depression-like behaviors and gene-expression changes in female mice

Autor: Arne Mørk, Ross Lazarus, Mette Nyegaard, Tue Fryland, Nico Liebenberg, Anders D. Børglum, Jonatan Pallesen, Michael Didriksen, Gregers Wegener, Veerle Paternoster, Bente Pakkenberg, Johan Palmfeldt, Kim Fejgin, Anto P. Rajkumar, Jens R. Nyengaard, Nicoletta Nava, Jane H. Christensen, Per Qvist, Gudrun Winther, Sanne H la Cour, Julie G. Donskov, Ole Mors

Publikováno v: Rajkumar, A P, Qvist, P, Donskov, J G, Lazarus, R, Pallesen, J, Nava, N, Winther, G, Liebenberg, N, Cour, S H L, Paternoster, V, Fryland, T, Palmfeldt, J, Fejgin, K, Mørk, A, Nyegaard, M, Pakkenberg, B, Didriksen, M, Nyengaard, J R, Wegener, G, Mors, O, Christensen, J H & Børglum, A D 2020, ' Reduced Brd1 expression leads to reversible depression-like behaviors and gene-expression changes in female mice ', Translational Psychiatry, vol. 10, 239 . https://doi.org/10.1038/s41398-020-00914-2
Rajkumar, A P, Qvist, P, Donskov, J G, Lazarus, R, Pallesen, J, Nava, N, Winther, G, Liebenberg, N, Cour, S H L, Paternoster, V, Fryland, T, Palmfeldt, J, Fejgin, K, Mørk, A, Nyegaard, M, Pakkenberg, B, Didriksen, M, Nyengaard, J R, Wegener, G, Mors, O, Christensen, J H & Børglum, A D 2020, ' Reduced Brd1 expression leads to reversible depression-like behaviors and gene-expression changes in female mice ', Translational Psychiatry, vol. 10, no. 1, 239 . https://doi.org/10.1038/s41398-020-00914-2
Translational Psychiatry, Vol 10, Iss 1, Pp 1-14 (2020)
Translational Psychiatry

The schizophrenia-associated gene, BRD1, encodes an epigenetic regulator in which chromatin interactome is enriched with genes implicated in mental health. Alterations in histone modifications and epigenetic regulation contribute to brain transcripto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95b3e6d859d81b73e9329873a92ee37e
https://doi.org/10.1038/s41398-020-00914-2

Hemisphere-dependent endocannabinoid system activity in prefrontal cortex and hippocampus of the Flinders Sensitive Line rodent model of depression

Autor: Beat Lutz, L. Bindila, Fabrício A. Moreira, C. Kirkedal, Heidi Kaastrup Müller, Betina Elfving, Nico Liebenberg, Gregers Wegener

Publikováno v: Kirkedal, C, Elfving, B, Müller, H K, Moreira, F A, Bindila, L, Lutz, B, Wegener, G & Liebenberg, N 2019, ' Hemisphere-dependent endocannabinoid system activity in prefrontal cortex and hippocampus of the Flinders Sensitive Line rodent model of depression ', Neurochemistry International, vol. 125, no. May, pp. 7-15 . https://doi.org/10.1016/j.neuint.2019.01.023

Altered endocannabinoid (eCB) signaling is suggested as an important contributor to the pathophysiology of depression. To further elucidate this, we conducted a study using a genetic rat model of depression, the Flinders Sensitive Line (FSL), and the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::868d18a3bc97159da4f0379ec586f648
https://pure.au.dk/portal/da/publications/hemispheredependent-endocannabinoid-system-activity-in-prefrontal-cortex-and-hippocampus-of-the-flinders-sensitive-line-rodent-model-of-depression(129baea9-ecc4-49a7-bab4-e49e2660f7fa).html

A Preclinical Study of Casein Glycomacropeptide as a Dietary Intervention for Acute Mania

Autor: Erik Jensen, Christina W. Fischer, Nico Liebenberg, Erik Roj Larsen, Vitor Silva Pereira, Gregers Wegener, Birgitte S. Kousholt

Publikováno v: Liebenberg, N, Jensen, E, Larsen, E R, Kousholt, B S, Pereira, V S, Fischer, C W & Wegener, G 2018, ' A Preclinical Study of Casein Glycomacropeptide as a Dietary Intervention for Acute Mania ', International Journal of Neuropsychopharmacology, vol. 21, no. 5, pp. 473-484 . https://doi.org/10.1093/ijnp/pyy012
International Journal of Neuropsychopharmacology

Background: Casein glycomacropeptide is a peptide that lacks phenylalanine, tyrosine, and tryptophan. This profile may enable it to deplete phenylalanine, tyrosine, and tryptophan, and subsequently the synthesis of dopamine and serotonin in the brain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79185364bc7fef36cacd99783cafaa39
https://findresearcher.sdu.dk:8443/ws/files/140658810/A_Preclinical_Study_of_Casein_Glycomacropeptide_as_a_Dietary_Intervention_for_Acute_Mania.pdf