Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Nico Lansu"'
Autor:
Kristiaan J. Lenos, Sander Bach, Leandro Ferreira Moreno, Sanne ten Hoorn, Nina R. Sluiter, Sanne Bootsma, Felipe A. Vieira Braga, Lisanne E. Nijman, Tom van den Bosch, Daniel M. Miedema, Erik van Dijk, Bauke Ylstra, Ruth Kulicke, Fred P. Davis, Nicolas Stransky, Gromoslaw A. Smolen, Robert R. J. Coebergh van den Braak, Jan N. M. IJzermans, John W. M. Martens, Sally Hallam, Andrew D. Beggs, Geert J. P. L. Kops, Nico Lansu, Vivian P. Bastiaenen, Charlotte E. L. Klaver, Maria C. Lecca, Khalid El Makrini, Clara C. Elbers, Mark P. G. Dings, Carel J. M. van Noesel, Onno Kranenburg, Jan Paul Medema, Jan Koster, Lianne Koens, Cornelis J. A. Punt, Pieter J. Tanis, Ignace H. de Hingh, Maarten F. Bijlsma, Jurriaan B. Tuynman, Louis Vermeulen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Colorectal cancer can lead to the development of peritoneal metastases, which are associated with worse disease outcome. Here, the authors characterize peritoneal metastases from 52 patients using RNA-seq and mutational sequencing and show a distinct
Externí odkaz:
https://doaj.org/article/369abe186b03465f8bac79e90a4d4606
Autor:
Erik van Dijk, Tom van den Bosch, Kristiaan J. Lenos, Khalid El Makrini, Lisanne E. Nijman, Hendrik F. B. van Essen, Nico Lansu, Michiel Boekhout, Joris H. Hageman, Rebecca C. Fitzgerald, Cornelis J. A. Punt, Jurriaan B. Tuynman, Hugo J. G. Snippert, Geert J. P. L. Kops, Jan Paul Medema, Bauke Ylstra, Louis Vermeulen, Daniël M. Miedema
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Intratumour heterogeneity (ITH) is associated with worse prognosis in cancer, and efficient frameworks to measure it are needed. Here the authors develop a method to estimate copy number heterogeneity, and propose that it is driven by chromosomal ins
Externí odkaz:
https://doaj.org/article/264d1331d97845559b189b69b84d9dcb
Autor:
Wilma H. M. Hoevenaar, Aniek Janssen, Ajit I. Quirindongo, Huiying Ma, Sjoerd J. Klaasen, Antoinette Teixeira, Bastiaan van Gerwen, Nico Lansu, Folkert H. M. Morsink, G. Johan A. Offerhaus, René H. Medema, Geert J. P. L. Kops, Nannette Jelluma
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Aneuploidy caused by chromosomal instability is frequently observed in cancer, but little is known about its contribution to tumor development. Here, the authors show that in the mouse intestine, the consequences of aneuploidy are exquisitely depende
Externí odkaz:
https://doaj.org/article/118f25f0a18f4b6ea689450fb6a3c626
Autor:
Loes A. Oosterhoff, Hedwig S. Kruitwagen, Monique E. van Wolferen, Bas W.M. van Balkom, Michal Mokry, Nico Lansu, Noortje A.M. van den Dungen, Louis C. Penning, Talitha C.F. Spanjersberg, Johannes W. de Graaf, Tomas Veenendaal, Flin Zomerdijk, Joost O. Fledderus, Bart Spee, Frank G. van Steenbeek
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Vasculature performs a critical function in tissue homeostasis, supply of oxygen and nutrients, and the removal of metabolic waste products. Vascular problems are implicated in a large variety of pathologies and accurate in vitro models resembling na
Externí odkaz:
https://doaj.org/article/d3bcd76059fd4137b465861aad4ad624
Autor:
Paul B. Essers, Julie Nonnekens, Yvonne J. Goos, Marco C. Betist, Marjon D. Viester, Britt Mossink, Nico Lansu, Hendrik C. Korswagen, Rob Jelier, Arjan B. Brenkman, Alyson W. MacInnes
Publikováno v:
Cell Reports, Vol 10, Iss 3, Pp 339-345 (2015)
The biogenesis of ribosomes and their coordination of protein translation consume an enormous amount of cellular energy. As such, it has been established that the inhibition of either process can extend eukaryotic lifespan. Here, we used next-generat
Externí odkaz:
https://doaj.org/article/7a0ee984de1c42b8b1b632d74737885c
Autor:
Sebastiaan van Heesch, Marieke Simonis, Markus J. van Roosmalen, Vamsee Pillalamarri, Harrison Brand, Ewart W. Kuijk, Kim L. de Luca, Nico Lansu, A. Koen Braat, Androniki Menelaou, Wensi Hao, Jeroen Korving, Simone Snijder, Lars T. van der Veken, Ron Hochstenbach, Alida C. Knegt, Karen Duran, Ivo Renkens, Najla Alekozai, Myrthe Jager, Sarah Vergult, Björn Menten, Ewart de Bruijn, Sander Boymans, Elly Ippel, Ellen van Binsbergen, Michael E. Talkowski, Klaske Lichtenbelt, Edwin Cuppen, Wigard P. Kloosterman
Publikováno v:
Cell Reports, Vol 9, Iss 6, Pp 2001-2010 (2014)
Genomic rearrangements are a common cause of human congenital abnormalities. However, their origin and consequences are poorly understood. We performed molecular analysis of two patients with congenital disease who carried de novo genomic rearrangeme
Externí odkaz:
https://doaj.org/article/3fde279ae3264a15b1b84b25ba00f8e2
Autor:
Marit W. Vermunt, Peter Reinink, Jeroen Korving, Ewart de Bruijn, Paul M. Creyghton, Onur Basak, Geert Geeven, Pim W. Toonen, Nico Lansu, Charles Meunier, Sebastiaan van Heesch, Hans Clevers, Wouter de Laat, Edwin Cuppen, Menno P. Creyghton
Publikováno v:
Cell Reports, Vol 9, Iss 2, Pp 767-779 (2014)
Understanding the complexity of the human brain and its functional diversity remain a major challenge. Distinct anatomical regions are involved in an array of processes, including organismal homeostasis, cognitive functions, and susceptibility to neu
Externí odkaz:
https://doaj.org/article/f2a52140da1e424a8aff2a3ac40ccfd4
Autor:
Michal Mokry, Arjan Boltjes, Lotte Slenders, Gemma Bel-Bordes, Kai Cui, Eli Brouwer, Joost M. Mekke, Marie A. C. Depuydt, Nathalie Timmerman, Farahnaz Waissi, Maarten C. Verwer, Adam W. Turner, Mohammad Daud Khan, Chani J. Hodonsky, Ernest Diez Benavente, Robin J. G. Hartman, Noortje A. M. van den Dungen, Nico Lansu, Emilia Nagyova, Koen H. M. Prange, Jason C. Kovacic, Johan L. M. Björkegren, Eleftherios Pavlos, Evangelos Andreakos, Heribert Schunkert, Gary K. Owens, Claudia Monaco, Aloke V. Finn, Renu Virmani, Nicholas J. Leeper, Menno P. J. de Winther, Johan Kuiper, Gert J. de Borst, Erik S. G. Stroes, Mete Civelek, Dominique P. V. de Kleijn, Hester M. den Ruijter, Folkert W. Asselbergs, Sander W. van der Laan, Clint L. Miller, Gerard Pasterkamp
Publikováno v:
Nature Cardiovascular Research. 1:1140-1155
Autor:
Emile E. Voest, Edwin Cuppen, Paul J. van Diest, Richard van Hillegersberg, Ewart de Bruijn, Nico Lansu, Wijnand M. Roessingh, Michal Mokry, Stefan J. Scherer, Frank L. Gerritse, Marco J. Koudijs, Isaac J. Nijman, Joost S. Vermaat
PDF file 2.7MB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a8fe7974b60a17f74e9fee598586451
https://doi.org/10.1158/1078-0432.22444404
https://doi.org/10.1158/1078-0432.22444404
Autor:
Emile E. Voest, Edwin Cuppen, Paul J. van Diest, Richard van Hillegersberg, Ewart de Bruijn, Nico Lansu, Wijnand M. Roessingh, Michal Mokry, Stefan J. Scherer, Frank L. Gerritse, Marco J. Koudijs, Isaac J. Nijman, Joost S. Vermaat
PDF file - 223K, Sanger Verification.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f079c9cef5b8253c74cf246f710e794
https://doi.org/10.1158/1078-0432.22444407
https://doi.org/10.1158/1078-0432.22444407