Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Nico J. Stam"'
Human serotonin 5-HT7receptor: cloning and pharmacological characterisation of two receptor variants
Autor:
Carolien Roesink, Anja Garritsen, Wiebe Olijve, Fred A. Dijcks, Anne van Herpen, Nico J. Stam
Publikováno v:
FEBS Letters. 413:489-494
Two splice variants of the 5-HT7 receptor were identified in human brain that differ in the lengths of their intracellular carboxy terminal tail. Identification of the variants of this receptor is of particular interest since the 5-HT7 receptor is kn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08e51d0d4f3112a4c67b2e9ccbed9208
https://doi.org/10.1016/s0014-5793(97)00964-2
https://doi.org/10.1016/s0014-5793(97)00964-2
Publikováno v:
FEBS Letters. 384:260-264
Here we report the cloning of a gene encoding a new member of the superfamily of G protein-coupled receptors. The gene encodes a protein of 365 amino acids closely resembling two recently cloned nucleotide binding receptors, called P2U and P2Y purino
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13b358caf5b4e14ed19b3f34f1ea7f17
https://doi.org/10.1016/0014-5793(96)00321-3
https://doi.org/10.1016/0014-5793(96)00321-3
Publikováno v:
Biochemical Pharmacology. 51:71-76
Previous work has shown that 5-hydroxytryptamine (5-HT)2A receptors can be radiolabelled with various radioligands, including partial agonists, such as [125I]-DOI and [3H]-DOB, and antagonists, such as [3H]-ketanserin and [3H]-spiperone. Because 5-HT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c91cf5133f918566c91fca008e25e627
https://doi.org/10.1016/0006-2952(95)02122-1
https://doi.org/10.1016/0006-2952(95)02122-1
Publikováno v:
NeuroReport. 4:1327-1330
We have used single cell clones of Swiss 3T3 cells transfected with genes for the human 5-HT1A or 5-HT2 receptor to study down-regulation and desensitization. After pre-incubation of the cells with serotonin agonists, a time-dependent decrease in [3H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccd68c76f4e7983b2760fb3ddbe51a8b
https://doi.org/10.1097/00001756-199309150-00010
https://doi.org/10.1097/00001756-199309150-00010
Publikováno v:
International Journal of Cancer. 47:544-550
HLA class-I expression has been investigated by biochemical methods in 14 Burkitt lymphoma (BL) cell lines and the corresponding Epstein-Barr virus (EBV)-transformed lymphoblastoid cell lines (LCL) derived from the same individuals. Selective down-re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc20a30aefb6922c70397c035809b52f
https://doi.org/10.1002/ijc.2910470412
https://doi.org/10.1002/ijc.2910470412
Publikováno v:
Alternatives to Laboratory Animals. 21:450-452
In the initial preclinical phase of the development of new psychotropic agents, potential drugs are generally characterised by in vitro receptor binding studies using rat brain preparations. We have recently, at this stage, incorporated assays using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35fb8c4fcdd73c3b8cd8acf87f76c966
https://doi.org/10.1177/026119299302100407
https://doi.org/10.1177/026119299302100407
Autor:
Mo Shahid, P. M. L. Vanderheyden, W. K. Makkink, P. N. M. Konings, Nico J. Stam, C. Van Alebeek, Gé S.F. Ruigt
Publikováno v:
Journal of receptor and signal transduction research. 15(1-4)
In order to set up the technique of semi-quantitative in situ hybridisation to detect the serotonin receptor mRNA levels in brain tissue, a panel of three Swiss 3T3 cell clones (named clones 66, 53 and 47) expressing the human 5-HT1A receptor at diff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c04e27fb77600056f82f6a1881f3ed3
https://pubmed.ncbi.nlm.nih.gov/8903956
https://pubmed.ncbi.nlm.nih.gov/8903956
Autor:
C. Van Alebeek, Jan Klomp, Nico J. Stam, A. M. L. Van Delft, Wiebe Olijve, P. M. L. Vanderheyden, T. De Boer
Publikováno v:
European journal of pharmacology. 269(3)
The 5-HT 2C receptor gene is unique among the members of the 5-HT receptor family by virtue of its genomic organisation. The human 5-HT 2C receptor gene, unlike many other genes for guanine nucleotide binding (G)-proteins, contains three introns whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f8ce53ae2cd13deb8c93df569d8ed36
https://pubmed.ncbi.nlm.nih.gov/7895773
https://pubmed.ncbi.nlm.nih.gov/7895773
Autor:
Hans-Gustaf Ljunggren, Nico J. Stam, Claes Öhlén, Jacques J. Neefjes, Petter Höglund, Marie-Thérèse Heemels, Judy Bastin, Ton N. M. Schumacher, Alain Townsend, Klas Kärre, Hidde L. Ploegh
Publikováno v:
Nature. 346(6283)
Major histocompatibility complex (MHC) class I molecules present antigen by transporting peptides from intracellularly degraded proteins to the cell surface for scrutiny by cytotoxic T cells. Recent work suggests that peptide binding may be required
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf008c802111be3df1213dbbc86403b3
https://pubmed.ncbi.nlm.nih.gov/2198471
https://pubmed.ncbi.nlm.nih.gov/2198471
Autor:
Sigurbjörg Torsteinsdóttir, Nico J. Stam, George Klein, Hidde L. Ploegh, Jacques Neefjes, M. G. Masucci
Publikováno v:
Cellular Immunology. 120:396-400
We have reported that Burkitt lymphomas (BL) that arise in HLA-A11 positive individuals are resistant to lysis by HLA-A11-specific and HLA-A11-restricted CTLs(10,11). Here we show that this phenomenon can be explained by a selective loss of the HLA-A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d5cc40314bdb6acc1213946e150d934
https://doi.org/10.1016/0008-8749(89)90207-4
https://doi.org/10.1016/0008-8749(89)90207-4