Intradermal vaccination of HPV-16 E6 synthetic peptides conjugated to an optimized Toll-like receptor 2 ligand shows safety and potent T cell immunogenicity in patients with HPV-16 positive (pre-)malignant lesions

Autor: Hans Gelderblom, Sjoerd H van der Burg, Ferry Ossendorp, Peggy J de Vos van Steenwijk, Mariette I E van Poelgeest, Inge Roozen, Willem-Jan Krebber, Cornelis J M Melief, Frank M Speetjens, Marij J P Welters, Nikki M Loof, Sanne Boekestijn, Catharina A H Janssen, Marije Slingerland, Gijs G Zom, A Rob P M Valentijn, Nico J Meeuwenoord, Gijs A van der Marel, Dmitri V Filippov

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 10, Iss 10 (2022)

Background Amplivant is a molecularly optimized Toll-like receptor 2 ligand that can be covalently conjugated to tumor peptide antigens. In preclinical models, amplivant-adjuvanted synthetic long peptides (SLPs) strongly enhanced antigen presentation

Externí odkaz: https://doaj.org/article/116d0102ba984134b3b45409c8b1b84b

Data from Efficient Induction of Antitumor Immunity by Synthetic Toll-like Receptor Ligand–Peptide Conjugates

Autor: Ferry Ossendorp, Cornelis J.M. Melief, Hermen S. Overkleeft, Gijsbert A. van der Marel, Dmitri V. Filippov, Nico J. Meeuwenoord, Christina F. Budden, Nikki M. Loof, Marcel G.M. Camps, Vinod Sommandas, Cedrik M. Britten, Selina Khan, Gijs G. Zom

Chemical conjugates comprising synthetic Toll-like receptor ligands (TLR-L) covalently bound to antigenic synthetic long peptides (SLP) are attractive vaccine modalities, which can induce robust CD8+ T-cell immune responses. Previously, we have shown

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1445c8e619d7dc1d47cd3adb1f435024
https://doi.org/10.1158/2326-6066.c.6548485.v1

Supplementary Figure Legends from Efficient Induction of Antitumor Immunity by Synthetic Toll-like Receptor Ligand–Peptide Conjugates

Autor: Ferry Ossendorp, Cornelis J.M. Melief, Hermen S. Overkleeft, Gijsbert A. van der Marel, Dmitri V. Filippov, Nico J. Meeuwenoord, Christina F. Budden, Nikki M. Loof, Marcel G.M. Camps, Vinod Sommandas, Cedrik M. Britten, Selina Khan, Gijs G. Zom

PDF file - 89K

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ed5ca3fb207eac28f33bcbb7b09cb5d
https://doi.org/10.1158/2326-6066.22537579.v1

Chemical synthesis of linear ADP-ribose oligomers up to pentamer and their binding to the oncogenic helicase ALC1†

Autor: Jim Voorneveld, Andreas G. Ladurner, Nico J. Meeuwenoord, Qiang Liu, Gunnar Knobloch, Dmitri V. Filippov, Gijsbert A. van der Marel, Herman S. Overkleeft

Publikováno v: Chemical Science
Chemical Science, 12(37), 12468-12475. ROYAL SOC CHEMISTRY

ADP-ribosylation is a pivotal post-translational modification that mediates various important cellular processes producing negatively charged biopolymer, poly (ADP-ribose), the functions of which need further elucidation. Toward this end, the availab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b78a977e17fb496683cf4b3b92cc1d75
http://europepmc.org/articles/PMC8480336

(Automated) synthesis of well-defined staphylococcus aureus wall teichoic acid fragments

Autor: Sara Ali, Thomas Bruyning, Jeroen D. C. Codée, Nina M. van Sorge, Astrid Hendriks, Rob van Dalen, Herman S. Overkleeft, Dmitri V. Filippov, Nico J. Meeuwenoord, Gijs A. van der Marel

Publikováno v: Chemistry (Weinheim an der Bergstrasse, Germany), 27(40), 10461-10469. Wiley-VCH Verlag
Chemistry-a European Journal, 27(40), 10461-10469. WILEY-V C H VERLAG GMBH
Chemistry-a European Journal
Chemistry (Weinheim an Der Bergstrasse, Germany)

Wall teichoic acids (WTAs) are important components of the cell wall of the opportunistic Gram‐positive bacterium Staphylococcus aureus. WTAs are composed of repeating ribitol phosphate (RboP) residues that are decorated with d‐alanine and N‐ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c9eb2a2349b9aecfcd39b5078b89626
https://hdl.handle.net/1887/3214360