Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Nico Gerstner"'
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Machine learning methods trained on cancer cell line panels are intensively studied for the prediction of optimal anti-cancer therapies. While classification approaches distinguish effective from ineffective drugs, regression approaches aim
Externí odkaz:
https://doaj.org/article/66d3b964c3f24e6badc30f7257c6b736
Autor:
Nico Gerstner, Tim Kehl, Kerstin Lenhof, Lea Eckhart, Lara Schneider, Daniel Stöckel, Christina Backes, Eckart Meese, Andreas Keller, Hans-Peter Lenhof
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Experimental high-throughput techniques, like next-generation sequencing or microarrays, are nowadays routinely applied to create detailed molecular profiles of cells. In general, these platforms generate high-dimensional and noisy data sets. For the
Externí odkaz:
https://doaj.org/article/d22b154b8f9e4316bd346f6623ee1e96
Publikováno v:
Bioinformatics
Motivation A major goal of personalized medicine in oncology is the optimization of treatment strategies given measurements of the genetic and molecular profiles of cancer cells. To further our knowledge on drug sensitivity, machine learning techniqu
Autor:
Hans-Peter Lenhof, Carolin Mayer, Nico Gerstner, Kerstin Lenhof, Anne Müller, Martin Hart, Eckart Meese, Tony Wyss-Coray, Tim Kehl, Jörn Walter, Caroline Diener, Lea Eckhart, Nadja Grammes, Oliver Hahn, Andreas Keller
Publikováno v:
Nucleic Acids Research
We present GeneTrail 3, a major extension of our web service GeneTrail that offers rich functionality for the identification, analysis, and visualization of deregulated biological processes. Our web service provides a comprehensive collection of biol
Autor:
Eckart Meese, Nadja Grammes, Norbert Graf, Oliver Kohlbacher, Lara Schneider, Hans-Peter Lenhof, Christina Backes, Kerstin Lenhof, Nico Gerstner, Andreas Keller, Markus Wallwiener, Tim Kehl, Kristina Thedinga, Christopher Mohr, Andreas D. Hartkopf, Benjamin Schubert
Publikováno v:
Bioinformatics
Motivation Breast cancer is the second leading cause of cancer death among women. Tumors, even of the same histopathological subtype, exhibit a high genotypic diversity that impedes therapy stratification and that hence must be accounted for in the t
Autor:
Nico Gerstner, Manfred Gessler, Hans-Peter Lenhof, Lara Schneider, Ute Distler, Tim Kehl, Eckart Meese, Nicole Ludwig, Jenny Wegert, Stefan Tenzer, Andreas Keller, Daniel Stöckel, Kathrin Kattler, Norbert Graf, Jörn Walter
Publikováno v:
International Journal of Cancer. 144:1432-1443
Wilms tumors are the most common type of pediatric kidney tumors. While the overall prognosis for patients is favorable, especially tumors that exhibit a blastemal subtype after preoperative chemotherapy have a poor prognosis. For an improved risk as
Autor:
Lara Schneider, Nico Gerstner, Nicole Ludwig, Jörn Walter, Tim Kehl, Norbert Graf, Stefan Tenzer, Daniel Stöckel, Kathrin Kattler, Eckart Meese, Markus Schick, Ulrich Keller, Jenny Wegert, Manfred Gessler, Andreas Keller, Ute Distler, Hans-Peter Lenhof
Publikováno v:
Bioinformatics
Motivation Transcriptional regulators play a major role in most biological processes. Alterations in their activities are associated with a variety of diseases and in particular with tumor development and progression. Hence, it is important to assess
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::475cc57385eeb36767f3ed276003e1ee
Autor:
Tim, Kehl, Lara, Schneider, Kathrin, Kattler, Daniel, Stöckel, Jenny, Wegert, Nico, Gerstner, Nicole, Ludwig, Ute, Distler, Stefan, Tenzer, Manfred, Gessler, Jörn, Walter, Andreas, Keller, Norbert, Graf, Eckart, Meese, Hans-Peter, Lenhof
Publikováno v:
International journal of cancer. 144(6)
Wilms tumors are the most common type of pediatric kidney tumors. While the overall prognosis for patients is favorable, especially tumors that exhibit a blastemal subtype after preoperative chemotherapy have a poor prognosis. For an improved risk as
Autor:
Florian Schmidt, Marcel H. Schulz, Tim Kehl, Christina Backes, Andreas Keller, Nico Gerstner, Daniel Stöckel, Lara Schneider, Eckart Meese, Hans-Peter Lenhof
Publikováno v:
Nucleic Acids Research
Transcriptional regulators such as transcription factors and chromatin modifiers play a central role in most biological processes. Alterations in their activities have been observed in many diseases, e.g. cancer. Hence, it is of utmost importance to
Publikováno v:
WASSERWIRTSCHAFT. 104:16-22