Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Nico C. van de Merbel"'
Publikováno v:
Journal of Chromatography Open, Vol 2, Iss , Pp 100025- (2022)
This review focuses on the deamidation of asparagine in monoclonal antibodies, one of the well-known degradation pathways. The importance of close monitoring of deamidation from early developability assessment to in vivo studies is discussed conseque
Externí odkaz:
https://doaj.org/article/4a5907208d3948cfb9941b6320065cf8
Autor:
Baubek Spanov, Victoria Aboagye, Oladapo Olaleye, Natalia Govorukhina, Nico C. van de Merbel, Rainer Bischoff
Publikováno v:
Frontiers in Chemistry, Vol 9 (2022)
Asparagine deamidation and aspartic acid isomerization in the complementarity determining regions (CDRs) of monoclonal antibodies may alter their affinity to the target antigen. Trastuzumab has two hot spots for deamidation and one position for isome
Externí odkaz:
https://doaj.org/article/4c384339d848482892f04d0f70870428
Publikováno v:
Biomolecules, Vol 11, Iss 12, p 1791 (2021)
There is often a need to isolate proteins from body fluids, such as plasma or serum, prior to further analysis with (targeted) mass spectrometry. Although immunoglobulin or antibody-based binders have been successful in this regard, they possess cert
Externí odkaz:
https://doaj.org/article/f1e925db81a74447be9d9a30b35351ef
Autor:
Oladapo Olaleye, Christian Graf, Baubek Spanov, Natalia Govorukhina, Matthew R. Groves, Nico C. van de Merbel, Rainer Bischoff
Publikováno v:
Journal of the American Society for Mass Spectrometry. 34:775-783
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::215780a6de00e5dabc043d560abb8780
https://doi.org/10.1021/jasms.3c00069
https://doi.org/10.1021/jasms.3c00069
Autor:
Bas Sleumer, Jordan Zwerwer, Martijn van Faassen, Michel J. Vos, Rainer Bischoff, Ido P. Kema, Nico C. van de Merbel
Publikováno v:
Clinical chemistry and laboratory medicine, 61(7). Walter de Gruyter GmbH
Objectives Sex hormone binding globulin (SHBG) is a hormone binding protein which plays an important role in regulating the transport and availability of biologically active androgens and estradiol to target cells and used to calculate free testoster
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c79f04892a2e718411f552e8199e16c
https://doi.org/10.1515/cclm-2022-1225
https://doi.org/10.1515/cclm-2022-1225
Autor:
Oladapo Olaleye, Baubek Spanov, Peter Bults, Anna van der Voort, Natalia Govorukhina, Gabe S. Sonke, Peter Horvatovich, Nico C. van de Merbel, Rainer Bischoff
Publikováno v:
Drug Metabolism and Disposition, 50(12), 249-256. AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS
Therapeutic proteins (TPs) are known to be heterogeneous due to modifications that occur during the production process and storage. Modifications may also occur in TPs after their administration to patients due to in vivo biotransformation. Ligand bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae87696c75e933ab48fb7eec5070321d
https://research.rug.nl/en/publications/de84de11-0a42-40fd-b01c-be0b04d60f7e
https://research.rug.nl/en/publications/de84de11-0a42-40fd-b01c-be0b04d60f7e
Autor:
Anne-Marie Jacobsen, Nico C. van de Merbel, Dorte K. Ditlevsen, Ketil Tvermosegaard, Frank Schalk, Wietske Lambert, Christoffer Bundgaard, Jan T. Pedersen, Nina Rosenqvist
Publikováno v:
Journal of the American Society for Mass Spectrometry. 34:441-451
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::704601712633ffcd09e93dae917f910d
https://doi.org/10.1021/jasms.2c00324
https://doi.org/10.1021/jasms.2c00324
Autor:
Bas Sleumer, Martijn van Faassen, Michel J. Vos, Rainer Bischoff, Ido P. Kema, Nico C. van de Merbel
Publikováno v:
Analytical and Bioanalytical Chemistry, 414, 6187-6200. SPRINGER HEIDELBERG
The human growth hormone GH1 (22 kDa) is a commonly measured biomarker for diagnosis and during treatment of growth disorders, but its quantification by ligand binding assays may be compromised by the occurrence of a number of isoforms. These can int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b28935a2824ca79aff7c35df0acf4fa6
https://doi.org/10.1007/s00216-022-04188-z
https://doi.org/10.1007/s00216-022-04188-z
Publikováno v:
Bioanalysis, 14(7), 397-400. FUTURE SCI LTD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8881670f04a5ceed7a4f0fa64f1a1f7
https://doi.org/10.4155/bio-2022-0032
https://doi.org/10.4155/bio-2022-0032
Autor:
Baubek Spanov, Bas Baartmans, Oladapo Olaleye, Simone Nicolardi, Natalia Govorukhina, Manfred Wuhrer, Nico C. van de Merbel, Rainer Bischoff
Publikováno v:
Analytical and Bioanalytical Chemistry, 415(8), 1505-1513. SPRINGER HEIDELBERG
Trastuzumab is known to be heterogeneous in terms of charge. Stressing trastuzumab under physiological conditions (pH 7.4 and 37 °C) increases charge heterogeneity further. Separation of charge variants of stressed trastuzumab at the intact protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4fb47a70166e8bd706c21d7627479d9
https://hdl.handle.net/1887/3590794
https://hdl.handle.net/1887/3590794
