Zobrazeno 1 - 10
of 138
pro vyhledávání: '"Nico, Lachmann"'
Autor:
Stephanie Guillet, Tomi Lazarov, Natasha Jordan, Bertrand Boisson, Maria Tello, Barbara Craddock, Ting Zhou, Chihiro Nishi, Rohan Bareja, Hairu Yang, Frederic Rieux-Laucat, Rosa Irene Fregel Lorenzo, Sabrina D Dyall, David Isenberg, David D'Cruz, Nico Lachmann, Olivier Elemento, Agnes Viale, Nicholas D Socci, Laurent Abel, Shigekazu Nagata, Morgan Huse, W Todd Miller, Jean-Laurent Casanova, Frédéric Geissmann
Publikováno v:
eLife, Vol 13 (2024)
Systemic lupus erythematosus (SLE) is an autoimmune disease, the pathophysiology and genetic basis of which are incompletely understood. Using a forward genetic screen in multiplex families with SLE, we identified an association between SLE and compo
Externí odkaz:
https://doaj.org/article/bbeacfc654b64900aa3479d5ae42195e
Autor:
Katrin Streckfuss‐Bömeke, Nicolle Kränkel, Christoph Maack, Renate B. Schnabel, Laura C. Zelarayán, Norbert Frey, Peter Jezzard, Martina Krüger, Nico Lachmann, Susanne Lutz, Claudia Noack, Eric Schoger, Katrin Schröder, Laura C. Sommerfeld, Sabine Steffens, Holger Winkels, Christina Würtz, Tanja Zeller, Eva A. Rog‐Zielinska, Peter Kohl
Publikováno v:
Physiological Reports, Vol 12, Iss 21, Pp n/a-n/a (2024)
Abstract “Medical scientists” are postgraduate investigators who are engaged in biomedical research, and either hold a biomedical PhD or are qualified in medicine but do not participate in patient care. Medical scientists constitute ~40% of staff
Externí odkaz:
https://doaj.org/article/98e54c7d18e6449687d8fed41c0804a1
Autor:
Claudio Rodriguez Gonzalez, Débora Basílio-Queirós, Anna-Lena Neehus, Sylvia Merkert, David Tschritter, Sinem Ünal, Jan Hegermann, Matthias Mörgelin, Jacinta Bustamante, Manuel Manfred Nietert, Ulrich Martin, Burkhard Tümmler, Antje Munder, Nico Lachmann
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionCystic fibrosis (CF) is a hereditary autosomal recessive disease driven by deleterious variants of the CFTR gene, leading, among other symptoms, to increased lung infection susceptibility. Mucus accumulation in the CF lung is, as of yet,
Externí odkaz:
https://doaj.org/article/bdb3543dfdf94471a237858b78293635
Autor:
Mania Ackermann, Fawaz Saleh, Shifaa M. Abdin, Anna Rafiei Hashtchin, Ingrid Gensch, Julia Golgath, Marco Carvalho Oliveira, Ariane H. H. Nguyen, Svenja Gaedcke, Arno Fenske, Mi-Sun Jang, Adan C. Jirmo, Markus Abeln, Gesine Hansen, Nico Lachmann
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Background There is a significant demand for intermediate-scale bioreactors in academic and industrial institutions to produce cells for various applications in drug screening and/or cell therapy. However, the application of these bioreactor
Externí odkaz:
https://doaj.org/article/a386a9eed5a141dcb1f49f98b94c1d5f
Autor:
Carina Jacobsen, Nina Plückebaum, George Ssebyatika, Sarah Beyer, Lucas Mendes-Monteiro, Jiayi Wang, Kai A. Kropp, Víctor González-Motos, Lars Steinbrück, Birgit Ritter, Claudio Rodríguez-González, Heike Böning, Eirini Nikolouli, Paul R. Kinchington, Nico Lachmann, Daniel P. Depledge, Thomas Krey, Abel Viejo-Borbolla
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract During primary varicella zoster virus (VZV) infection, infected lymphocytes drive primary viremia, causing systemic dissemination throughout the host, including the skin. This results in cytokine expression, including interferons (IFNs), whi
Externí odkaz:
https://doaj.org/article/0569487febc14ccf86b8f547b6011d69
Autor:
Killian Hurley, Mari Ozaki, Quentin Philippot, Liam Galvin, David Crosby, Mary Kirwan, Deborah R. Gill, Konstantinos-Dionysios Alysandratos, Gisli Jenkins, Matthias Griese, Nadia Nathan, Raphael Borie, Deborah Snijders, Nicolaus Schwerk, Nico Lachmann, Daniel O'Toole
Publikováno v:
EBioMedicine, Vol 104, Iss , Pp 105135- (2024)
Summary: Interstitial lung diseases (ILDs) in adults and children (chILD) are a heterogeneous group of lung disorders leading to inflammation, abnormal tissue repair and scarring of the lung parenchyma often resulting in respiratory failure and death
Externí odkaz:
https://doaj.org/article/d1a53dcebee04116a10cbbac5081b2fb
Autor:
Christopher Jahn, Malte Juchem, Kristina Sonnenschein, Anika Gietz, Theresa Buchegger, Nico Lachmann, Gudrun Göhring, Yvonne Lisa Behrens, Christian Bär, Thomas Thum, Jeannine Hoepfner
Publikováno v:
Stem Cell Research, Vol 77, Iss , Pp 103404- (2024)
Fabry disease (FD) is a rare and inherited monogenetic disease caused by mutations in the X-chromosomal alpha-galactosidase A gene GLA concomitant with accumulation of its substrate globotriaosylceramide (Gb3) and multi-organ symptoms. We derived an
Externí odkaz:
https://doaj.org/article/3b872bd17b574fc09cc9f159e84b496d
Autor:
Anja Schweikert, Sarah Kenny, Irene Oglesby, Arlene Glasgow, Chiara de Santi, Ingrid Gensch, Nico Lachmann, Tifenn Desroziers, Camille Fletcher, Deborah Snijders, Nadia Nathan, Killian Hurley, COST Open-ILD Group Management Committee
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract Background Interstitial lung diseases (ILD) are a group of rare lung diseases with severe outcomes. The COST Innovator Grant aims to establish a first-of-a-kind open-access Biorepository of patient-derived induced pluripotent stem cells (iPS
Externí odkaz:
https://doaj.org/article/c577f47b544e48a19a97049655f25144
Autor:
Gesine Hansen, Axel Schambach, Christine S Falk, Arnold Kloos, Michael Morgan, Shifaa M. Abdin, Daniela Paasch, Nico Lachmann, Marco Carvalho Oliveira, Mi-Sun Jang, Mania Ackermann, Andriana Stamopoulou, Philipp J Mroch, Constantin S von Kaisenberg, Michael Heuser, Thomas Moritz
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 12 (2023)
Background Macrophages have recently become attractive therapeutics in cancer immunotherapy. The potential of macrophages to infiltrate and influence solid malignancies makes them promising targets for the chimeric antigen receptor (CAR) technology t
Externí odkaz:
https://doaj.org/article/95887552adbe4426b971a8b340ad3b4a
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 19 (2023)
Alveolar macrophages (AMs) are the sentinel cells of the alveolar space, maintaining homeostasis, fending off pathogens, and controlling lung inflammation. During acute lung injury, AMs orchestrate the initiation and resolution of inflammation in ord
Externí odkaz:
https://doaj.org/article/4e72f0308fc942a4a679abd061c98b8d