Výsledky vyhledávání - "Niclas Tue Hansen"

Akademický článek

The type 1 diabetes - HLA susceptibility interactome--identification of HLA genotype-specific disease genes for type 1 diabetes.

Autor: Caroline Brorsson, Niclas Tue Hansen, Regine Bergholdt, Søren Brunak, Flemming Pociot

Publikováno v: PLoS ONE, Vol 5, Iss 3, p e9576 (2010)

The individual contribution of genes in the HLA region to the risk of developing type 1 diabetes (T1D) is confounded by the high linkage disequilibrium (LD) in this region. Using a novel approach we have combined genetic association data with informa

Externí odkaz: https://doaj.org/article/b4828d9974964d4880cb8dd102cea6ea

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Heterozygous deletion at the RLN1 locus in a family with testicular germ cell cancer identified by integrating copy number variation data with phenome and interactome information

Autor: Ramneek Gupta, Niclas Tue Hansen, Ulrik Ralfkiaer, Thomas Skøt Jensen, Søren Brunak, Anne Marie Ottesen, E. Rajpert-De Meyts, M. Scheel, N E Skakkebaek, Daniel Edsgärd

Publikováno v: International Journal of Andrology. 34:e122-e132

Summary To search for disease-related copy number variations (CNVs) in families with a high frequency of germ cell tumours (GCT), we analysed 16 individuals from four families by array comparative genomic hybridization (aCGH) and applied an integrati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::723c990096a1660d641d757f1b16b31f
https://doi.org/10.1111/j.1365-2605.2011.01188.x

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A large-scale analysis of tissue-specific pathology and gene expression of human disease genes and complexes

Autor: Søren Brunak, Patricia K. Donahoe, E. Olof Karlberg, Aron Charles Eklund, Francisco S. Roque, Zoltan Szallasi, Thomas Skøt Jensen, Niclas Tue Hansen, Kasper Lage

Publikováno v: Proceedings of the National Academy of Sciences. 105:20870-20875

Heritable diseases are caused by germ-line mutations that, despite tissuewide presence, often lead to tissue-specific pathology. Here, we make a systematic analysis of the link between tissue-specific gene expression and pathological manifestations i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba4cad4a63757ccf28085bab2266f4a8
https://doi.org/10.1073/pnas.0810772105

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Meta-analysis of heterogeneous data sources for genome-scale identification of risk genes in complex phenotypes

Publikováno v: Pers, T H, Hansen, N T, Hansen, K L, Koefoed, P, Dworzynski, P, Miller, M L, Zacharov, T F, Mellerup, E T, Dam, H F, Andreassen, O A, Djurovic, S, Melle, I, Børglum, A D, Werge, T, Purcell, S, Ferreira, M A, Kouskoumvekaki, I, Workman, C, Hansen, T, Mors, O & Brunak, S 2011, ' Meta-analysis of heterogeneous data sources for genome-scale identification of risk genes in complex phenotypes ', Genetic Epidemiology, vol. 35, no. 5, pp. 318-32 . https://doi.org/10.1002/gepi.20580

To access publisher's full text version of this article click on the hyperlink at the bottom of the page Meta-analyses of large-scale association studies typically proceed solely within one data type and do not exploit the potential complementarities

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e538734309658c95489806291d5dc95
https://pubmed.ncbi.nlm.nih.gov/21484861

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The type 1 diabetes - HLA susceptibility interactome--identification of HLA genotype-specific disease genes for type 1 diabetes

Autor: Flemming Pociot, Søren Brunak, Caroline Brorsson, Regine Bergholdt, Niclas Tue Hansen

Publikováno v: PLoS ONE, Vol 5, Iss 3, p e9576 (2010)
PLoS ONE
Brorsson, C, Hansen, N T, Bergholdt, R, Brunak, S & Pociot, F 2010, ' The Type 1 Diabetes-HLA Susceptibility Interactome-Identification of HLA Genotype-Specific Disease Genes for Type 1 Diabetes ', P L o S One, vol. 5, no. 3, pp. e9576 . https://doi.org/10.1371/journal.pone.0009576

Background: The individual contribution of genes in the HLA region to the risk of developing type 1 diabetes (T1D) is confounded by the high linkage disequilibrium (LD) in this region. Using a novel approach we have combined genetic association data

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9cf4005e3405df4dc1e4e0e17534a68
http://europepmc.org/articles/PMC2832689?pdf=render

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Dissecting spatio-temporal protein networks driving human heart development and related disorders

Publikováno v: Molecular Systems Biology
Hansen, K L, Mølgård, K, Greenway, S, Wakimoto, H, Gorham, J M, Workman, C, Bendsen, E, Hansen, N T, Rigina, O, Roque, F J S S A, Wiese, C, Christoffels, V M, Roberts, A E, Smoot, L B, Pu, W T, Donahoe, P K, Tommerup, N, Brunak, S, Seidman, C E, Seidman, J G & Larsen, L A 2010, ' Dissecting spatio-temporal protein networks driving human heart development and related disorders ', Molecular Systems Biology, vol. 6, pp. 381 . https://doi.org/10.1038/msb.2010.36
Molecular systems biology, 6. Wiley-Blackwell
Molecular Systems Biology, 6. Wiley-Blackwell

Aberrant organ development is associated with a wide spectrum of disorders, from schizophrenia to congenital heart disease, but systems-level insight into the underlying processes is very limited. Using heart morphogenesis as general model for dissec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::139aef34459e2ad3b56cf92d386d7042
http://hdl.handle.net/1721.1/61761

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Generating genome-scale candidate gene lists for pharmacogenomics

Autor: Russ B. Altman, Søren Brunak, Niclas Tue Hansen

Publikováno v: Clinical pharmacology and therapeutics. 86(2)

A critical task in pharmacogenomics is identifying genes that may be important modulators of drug response. High-throughput experimental methods are often plagued by false positives and do not take advantage of existing knowledge. Candidate gene list

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ff5ea16cb3984af2d35033f399ebc7f
https://pubmed.ncbi.nlm.nih.gov/19369935

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Prediction of pH-dependent aqueous solubility of Histone Deacetylase (HDAC) inhibitors

Autor: Fredrik Björkling, S.M. Vadlamudi, Irene Kouskoumvekaki, Svava Ósk Jónsdóttir, Niclas Tue Hansen

Publikováno v: SAR and QSAR in environmental research. 19(1-2)

Recently we developed a model for prediction of pH-dependent aqueous solubility of drugs and drug like molecules. In the present work, the model was applied on a series of novel Histone Deacetylases (HDAC) inhibitors discovered at TopoTarget. The app

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f172d7c1a2a2fd27bcb65c89a70ca8c
https://pubmed.ncbi.nlm.nih.gov/18311642

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