Stimulation of Mononuclear Cells Through Toll-Like Receptor 9 Induces Release of Microvesicles Expressing Double-Stranded DNA and Galectin 3-Binding Protein in an Interferon-α-Dependent Manner

Autor: Niclas Stefan Rasmussen, Christoffer Tandrup Nielsen, Søren Jacobsen, Claus Henrik Nielsen

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

Background: Microvesicles (MVs) expressing the type 1 interferon (IFN)-inducible protein galectin-3 binding protein (G3BP) may play a pathogenic role in systemic lupus erythematosus (SLE). Co-expression of double-stranded DNA (dsDNA) on such MVs may

Externí odkaz: https://doaj.org/article/2f04433ec2834c25a2ca677c53fc5245

Microvesicles in active lupus nephritis show Toll-like receptor 9-dependent co-expression of galectin-3 binding protein and double-stranded DNA

Autor: Niclas Stefan Rasmussen, Søren Jacobsen, Claus Henrik Nielsen, Christoffer Tandrup Nielsen

Publikováno v: Clin Exp Immunol

Summary Circulating microvesicles (MVs) from patients with systemic lupus erythematosus (SLE) express the type 1 interferon (IFN)-inducible protein galectin-3 binding protein (G3BP), which may enhance their deposition in the glomerular basement membr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c3f4962c20ad8ea7f24080731b550a4
https://doi.org/10.1111/cei.13569

Erythrocytes restrict microvesicle‐induced production of reactive oxygen species by polymorphonuclear leukocytes

Autor: Line Kjær Winberg, Niclas Stefan Rasmussen, Claus Henrik Nielsen, Søren Jacobsen

Publikováno v: APMIS. 127:538-542

Microvesicles (MVs) are extracellular vesicles released by several cell types upon activation or apoptosis. MVs have the potential to activate complement, which has been suggested to mediate their clearance. However, it is not clear how complement-op

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8263bccf5b6424a9983f51862c2f4aa
https://doi.org/10.1111/apm.12954

A review of studies of the proteomes of circulating microparticles: key roles for galectin-3-binding protein-expressing microparticles in vascular diseases and systemic lupus erythematosus

Autor: Christoffer Tandrup Nielsen, Niclas Stefan Rasmussen, Søren Jacobsen, Niels H. H. Heegaard, Ole Østergaard

Publikováno v: Clinical Proteomics, Vol 14, Iss 1, Pp 1-24 (2017)
Clinical Proteomics
Nielsen, C T, Østergaard, O, Rasmussen, N S, Jacobsen, S & Heegaard, N H H 2017, ' A review of studies of the proteomes of circulating microparticles : Key roles for galectin-3-binding protein-expressing microparticles in vascular diseases and systemic lupus erythematosus ', Clinical Proteomics, vol. 14, 11 . https://doi.org/10.1186/s12014-017-9146-0

Subcellular microvesicles (MVs) have attracted increasing interest during the past decades. While initially considered as inert cellular debris, several important roles for MVs in physiological homeostasis, cancer, cardiovascular, and autoimmune dise

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ca0e707604ec7ad6d4877560388ddbf
http://link.springer.com/article/10.1186/s12014-017-9146-0

131 Stimulation of mononuclear cells through toll-like receptor 9 induces release of microvesicles expressing DNA and galectin 3-binding protein in an interferon--dependent manner

Autor: Christoffer Tandrup Nielsen, Niclas Stefan Rasmussen, Søren Jacobsen, Claus Henrik Nielsen

Publikováno v: Abstracts.

Background Microvesicles (MVs) expressing the type 1 interferon (IFN)-inducible protein galectin-3 binding protein (G3BP) may play a pathogenic role in systemic lupus erythematosus (SLE). Co-expression of DNA on such MVs may render them immunogenic a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3f8299ae2900782174cad69f2c0ccf99
https://doi.org/10.1136/lupus-2019-lsm.131