Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Niclas Pryk"'
Autor:
Anat Bashan, Frank Schulz, Johannes Zuegg, Niclas Pryk, Ada Yonath, Walter Thiel, Donna Matzov, Pandian Sokkar, Julia E. Bandow, Pascal Dietze, Elsa Sanchez-Garcia, Sascha Heinrich, David Möller, Gerhard König, Giuseppe Cimicata
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Due to the development of resistance against commonly used antibiotics, new derivatives that avoid resistance mechanisms need to be developed. To address this problem, a rational prioritization strategy is outlined for macrolide antibiot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7be7d83984e8b59ac582e20b854f5675
https://www.ncbi.nlm.nih.gov/pubmed/34750269
https://www.ncbi.nlm.nih.gov/pubmed/34750269
Autor:
Frank Schulz, David Möller, Marius Grote, Niclas Pryk, Susanna Kushnir, A. Ismail-Ali, Julian Erver
Publikováno v:
Organicbiomolecular chemistry. 17(26)
The concept of combinatorial biosynthesis promises access to compound libraries based on privileged natural scaffolds. Ever since the elucidation of the biosynthetic pathway towards the antibiotic erythromycin A in 1990, the predictable manipulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26bb7092479dbcc023370e97aa835e39
https://pubmed.ncbi.nlm.nih.gov/31090778
https://pubmed.ncbi.nlm.nih.gov/31090778
Autor:
Niclas Pryk, M. Pflieger, A. Ismail-Ali, Alfred Wittinghofer, Susanna Kushnir, Frank Schulz, Eyad K. Fansa, Samir Yahiaoui
Publikováno v:
Organic & Biomolecular Chemistry. 14:7671-7675
The controlled derivatization of natural products is of great importance for their use in drug discovery. The ideally rapid generation of compound libraries for structure-activity relationship studies is of particular concern. We here use modified bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b0744993f631b1b9aed87e0826d6550
https://doi.org/10.1039/c6ob01201a
https://doi.org/10.1039/c6ob01201a
Autor:
Niclas Pryk, Frank Schulz
Publikováno v:
Nature Chemistry. 7:102-104
Mutated enzymes are useful tools for the investigation of the biosynthetic routes to natural products. Now, they are used in a new approach to carry functionalized substrates through the synthesis and produce simplified or modified unnatural compound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b293f5dbe2bae79fb494437ab78195d1
https://doi.org/10.1038/nchem.2168
https://doi.org/10.1038/nchem.2168
Autor:
Niclas, Pryk, Frank, Schulz
Publikováno v:
Nature chemistry. 7(2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d923f0150e20724b36cc0c0bf3a7099a
https://pubmed.ncbi.nlm.nih.gov/25615663
https://pubmed.ncbi.nlm.nih.gov/25615663