Zobrazeno 1 - 10
of 210
pro vyhledávání: '"Niclas G, Karlsson"'
Autor:
Leïla Bechtella, Jin Chunsheng, Kerstin Fentker, Güney R. Ertürk, Marc Safferthal, Łukasz Polewski, Michael Götze, Simon Y. Graeber, Gaël M. Vos, Weston B. Struwe, Marcus A. Mall, Philipp Mertins, Niclas G. Karlsson, Kevin Pagel
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract The dense O-glycosylation of mucins plays an important role in the defensive properties of the mucus hydrogel. Aberrant glycosylation is often correlated with inflammation and pathology such as COPD, cancer, and Crohn’s disease. The inhere
Externí odkaz:
https://doaj.org/article/4bdedb1fc9504ebeaa9b03b3bb8ac159
Autor:
Bashar Shuoker, Michael J. Pichler, Chunsheng Jin, Hiroka Sakanaka, Haiyang Wu, Ana Martínez Gascueña, Jining Liu, Tine Sofie Nielsen, Jan Holgersson, Eva Nordberg Karlsson, Nathalie Juge, Sebastian Meier, Jens Preben Morth, Niclas G. Karlsson, Maher Abou Hachem
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
This study offers molecular insight into the sialidase and fucosidase decapping apparatus that initiates growth on mucin and promotes nutrient sharing by the dedicated mucolytic symbiont Akkermansia muciniphila with the mucus-associated microbiota.
Externí odkaz:
https://doaj.org/article/9a041ee102734a0eac2f4911f764b7f1
Autor:
Elin Andersson, Emil Tykesson, L. Stefan Lohmander, Niclas G. Karlsson, Chunsheng Jin, Ekaterina Mirgorodskaya, Per Swärd, André Struglics
Publikováno v:
Osteoarthritis and Cartilage Open, Vol 5, Iss 3, Pp 100380- (2023)
Objective: To validate a quantitative high performance liquid chromatography (HPLC) assay for chondroitin sulfate (CS) and hyaluronic acid (HA) in synovial fluid, and to analyze glycan-patterns in patient samples. Design: Synovial fluid from osteoart
Externí odkaz:
https://doaj.org/article/0855358b16f64dcda72abfe0193038b6
Autor:
Paolo Contessotto, Renza Spelat, Federico Ferro, Vaidas Vysockas, Aušra Krivickienė, Chunsheng Jin, Sandrine Chantepie, Clizia Chinello, Audrys G. Pauza, Camilla Valente, Mindaugas Rackauskas, Alvise Casara, Vilma Zigmantaitė, Fulvio Magni, Dulce Papy-Garcia, Niclas G. Karlsson, Eglė Ereminienė, Abhay Pandit, Mark Da Costa
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
The study of the pathophysiology and possible interventions for non-ST-segment elevation myocardial infarction is hindered by the lack of a reproducible pre-clinical model. Here, authors develop an ovine model to reproduce post-ischemic remodeling in
Externí odkaz:
https://doaj.org/article/006423bd42ef408ab58fac9fefcc939e
Autor:
Renza Spelat, Federico Ferro, Paolo Contessotto, Amal Aljaabary, Sergio Martin-Saldaña, Chunsheng Jin, Niclas G. Karlsson, Maura Grealy, Markus M. Hilscher, Fulvio Magni, Clizia Chinello, Michelle Kilcoyne, Abhay Pandit
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-16 (2022)
Transcriptomic and proteomic analyses reveal that glycosylation and carbohydrate metabolism are central processes in heart regeneration in zebrafish, including a shift from OXPHOS to glycolysis seven days after injury.
Externí odkaz:
https://doaj.org/article/60800cb8f5ec42a897241778790cb149
Autor:
Shan Huang, Kristina A. Thomsson, Chunsheng Jin, Henrik Ryberg, Nabangshu Das, André Struglics, Ola Rolfson, Lena I. Björkman, Thomas Eisler, Tannin A. Schmidt, Gregory D. Jay, Roman Krawetz, Niclas G. Karlsson
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
The primary aim of the study was to identify inflammatory markers relevant for osteoarthritis (OA)-related systemic (plasma) and local (synovial fluid, SF) inflammation. From this, we looked for inflammatory markers that coincided with the increased
Externí odkaz:
https://doaj.org/article/6b701682bbad4a48b68b04253d62c085
Autor:
Michael Jakob Pichler, Chihaya Yamada, Bashar Shuoker, Camila Alvarez-Silva, Aina Gotoh, Maria Louise Leth, Erwin Schoof, Toshihiko Katoh, Mikiyasu Sakanaka, Takane Katayama, Chunsheng Jin, Niclas G. Karlsson, Manimozhiyan Arumugam, Shinya Fushinobu, Maher Abou Hachem
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The assembly and maturation of the early life microbiome has life-long effects on human health. Here, the authors combine omics, functional assays and structural analyses to characterize the catabolic pathways that support the growth of butyrate prod
Externí odkaz:
https://doaj.org/article/93e13acc192c463a8e81c96141510b43
Autor:
Rebecca L. Miller, Scott E. Guimond, Ralf Schwörer, Olga V. Zubkova, Peter C. Tyler, Yongmei Xu, Jian Liu, Pradeep Chopra, Geert-Jan Boons, Márkó Grabarics, Christian Manz, Johanna Hofmann, Niclas G. Karlsson, Jeremy E. Turnbull, Weston B. Struwe, Kevin Pagel
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Heparan sulfates (HS) contain functionally relevant structural motifs, but determining their monosaccharide sequence remains challenging. Here, the authors develop an ion mobility mass spectrometry-based method that allows unambiguous characterizatio
Externí odkaz:
https://doaj.org/article/771c43443fb14659b5131577553e2f14
Autor:
Miguel A. Rojas-Macias, Julien Mariethoz, Peter Andersson, Chunsheng Jin, Vignesh Venkatakrishnan, Nobuyuki P. Aoki, Daisuke Shinmachi, Christopher Ashwood, Katarina Madunic, Tao Zhang, Rebecca L. Miller, Oliver Horlacher, Weston B. Struwe, Yu Watanabe, Shujiro Okuda, Fredrik Levander, Daniel Kolarich, Pauline M. Rudd, Manfred Wuhrer, Carsten Kettner, Nicolle H. Packer, Kiyoko F. Aoki-Kinoshita, Frédérique Lisacek, Niclas G. Karlsson
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Glycomics is gaining momentum in basic, translational and clinical research. Here, the authors review current reporting standards and analysis tools for mass-spectrometry-based glycomics, and propose an e-infrastructure for standardized reporting and
Externí odkaz:
https://doaj.org/article/8f37916676f94c028d37e7e01c2da22a
Autor:
Qiujin Shen, Karol Polom, Coralie Williams, Felipe Marques Souza de Oliveira, Mariana Guergova-Kuras, Frederique Lisacek, Niclas G. Karlsson, Franco Roviello, Masood Kamali-Moghaddam
Publikováno v:
EBioMedicine, Vol 44, Iss , Pp 322-333 (2019)
Background: Gastric cancer (GC) is the third leading cause of cancer death. Early detection is a key factor to reduce its mortality. Methods: We retrospectively collected pre- and postoperative serum samples as well as tumour tissues and adjacent nor
Externí odkaz:
https://doaj.org/article/c5de3c81eb81402798ead55e42684e81