Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Nicla Porciello"'
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-16 (2022)
Abstract Profiling the T-Cell Receptor (TCR) repertoire is establishing as a potent approach to investigate autologous and treatment-induced antitumor immune response. Technical and computational breakthroughs, including high throughput next-generati
Externí odkaz:
https://doaj.org/article/829ea4156d994194b368ba84cb9bcea9
Autor:
Anna-Lisa Lanz, Giulia Masi, Nicla Porciello, André Cohnen, Deborah Cipria, Dheeraj Prakaash, Štefan Bálint, Roberto Raggiaschi, Donatella Galgano, David K. Cole, Marco Lepore, Omer Dushek, Michael L. Dustin, Mark S.P. Sansom, Antreas C. Kalli, Oreste Acuto
Publikováno v:
Cell Reports, Vol 36, Iss 6, Pp 109531- (2021)
Externí odkaz:
https://doaj.org/article/a6cb432e0b0a4011bea51b73db0ce5dd
Autor:
Nicla Porciello, Paola Grazioli, Antonio F. Campese, Martina Kunkl, Silvana Caristi, Marta Mastrogiovanni, Michela Muscolini, Francesca Spadaro, Cédric Favre, Jacques A. Nunès, Aldo Borroto, Balbino Alarcon, Isabella Screpanti, Loretta Tuosto
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
CD28 transmits co-stimulatory signals for the activation of both mouse and human T cells, but in vivo hyperactivation of CD28 has opposite effects on system immunity. Here, the authors show that a single amino acid difference between mouse and human
Externí odkaz:
https://doaj.org/article/e98ff31ccbfc47539c572574b4d9cb31
Autor:
Martina Kunkl, Marta Mastrogiovanni, Nicla Porciello, Silvana Caristi, Emanuele Monteleone, Stefano Arcieri, Loretta Tuosto
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
CD28 is an important co-stimulatory receptor for T lymphocytes that, in humans, delivers TCR-independent signal leading to the up-regulation of pro-inflammatory cytokines. We have recently reported that CD28 autonomous signaling induces the expressio
Externí odkaz:
https://doaj.org/article/65434f7d7a0f4cc3a07027357435ae21
Publikováno v:
F1000Research, Vol 7 (2018)
Regulation of immune responses is critical for ensuring pathogen clearance and for preventing reaction against self-antigens. Failure or breakdown of immunological tolerance results in autoimmunity. CD28 is an important co-stimulatory receptor expres
Externí odkaz:
https://doaj.org/article/72f68c38a7494f84be2ca9103cc4bb83
Autor:
Loretta Tuosto, Martina Kunkl, Nicla Porciello, Marta Mastrogiovanni, Cristina Capuano, Federica Lucantoni, Chiara Moretti, Jenny L. Persson, Ricciarda Galandrini, Raffaella Buzzetti
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Phosphatidylinositol 4,5-biphosphate (PIP2) is a membrane phospholipid that controls the activity of several proteins regulating cytoskeleton reorganization, cytokine gene expression, T cell survival, proliferation, and differentiation. Phosphatidyli
Externí odkaz:
https://doaj.org/article/e96e373464ff40e09cc22f04e14e7df1
Autor:
Fabiana Paladini, Nicla Porciello, Giorgio Camilli, Sinem Tuncer, Elisa Cocco, Maria Teresa Fiorillo, Rosa Sorrentino
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e112646 (2014)
Complex immune and neurodegenerative disorders are the result of multiple interactions between common genetic variations having, individually, a weak effect on the disease susceptibility or resistance. Interestingly, some genes have been found to be
Externí odkaz:
https://doaj.org/article/8eb0e69d7dfc44d3873b223d54eac904
Autor:
Nicla Porciello, Deborah Cipria, Giulia Masi, Anna-Lisa Lanz, Edoardo Milanetti, Alessandro Grottesi, Duncan Howie, Steve P. Cobbold, Lothar Schermelleh, Hai-Tao He, Marco D’Abramo, Nicolas Destainville, Oreste Acuto, Konstantina Nika
Publikováno v:
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Theoretical work suggests that collective spatiotemporal behaviour of integral membrane proteins (IMPs) can be modulated by annular lipids sheathing their hydrophobic moiety. Here, we present evidence for this prediction in a natural membrane by inve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60e7ce1fc6756e208d29fd9eed06828c
https://hal.archives-ouvertes.fr/hal-03780160
https://hal.archives-ouvertes.fr/hal-03780160
Autor:
Nicla Porciello, Deborah Cipria, Giulia Masi, Anna-Lisa Lanz, Edoardo Milanetti, Alessandro Grottesi, Duncan Howie, Steve P. Cobbold, Lothar Schermelleh, Hai-Tao He, Marco D’Abramo, Nicolas Destainville, Oreste Acuto, Konstantina Nika
Publikováno v:
Journal of Biological Chemistry
Journal of Biological Chemistry, 2022, 298 (12), pp.102663. ⟨10.1016/j.jbc.2022.102663⟩
Journal of Biological Chemistry, 2022, 298 (12), pp.102663. ⟨10.1016/j.jbc.2022.102663⟩
International audience; Theoretical work suggests that collective spatiotemporal behaviour of integral membrane proteins (IMPs) should be modulated by boundary lipids sheathing their membrane anchors. Here, we show evidence for this prediction whilst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::733a8f1019453adaef9917d261a53b4b
https://pubmed.ncbi.nlm.nih.gov/36372231
https://pubmed.ncbi.nlm.nih.gov/36372231
Autor:
Nicla Porciello, Dheeraj Prakaash, Michael L. Dustin, Antreas C. Kalli, Oreste Acuto, Roberto Raggiaschi, Marco Lepore, Omer Dushek, Giulia Masi, Andre Cohnen, Deborah Cipria, Mark S.P. Sansom, Anna-Lisa Lanz, David K. Cole, Donatella Galgano, Štefan Bálint
Publikováno v:
Cell Reports, Vol 36, Iss 6, Pp 109531-(2021)
Cell Reports
Cell Reports, Vol 36, Iss 2, Pp 109375-(2021)
Cell Reports
Cell Reports, Vol 36, Iss 2, Pp 109375-(2021)
Summary The mechanism of T cell antigen receptor (TCR-CD3) signaling remains elusive. Here, we identify mutations in the transmembrane region of TCRβ or CD3ζ that augment peptide T cell antigen receptor (pMHC)-induced signaling not explicable by en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcb6dde632a2c24c74b13f637e2f597a
http://www.sciencedirect.com/science/article/pii/S2211124721009621
http://www.sciencedirect.com/science/article/pii/S2211124721009621