Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Nicky M Boontje"'
Autor:
Viola Kooij, Pingbo Zhang, Sander R Piersma, Vasco Sequeira, Nicky M Boontje, Paul J M Wijnker, Connie R Jiménez, Kornelia E Jaquet, Cris dos Remedios, Anne M Murphy, Jennifer E Van Eyk, Jolanda van der Velden, Ger Jm Stienen
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e74847 (2013)
AIMS:Protein kinase Cα (PKCα) is one of the predominant PKC isoforms that phosphorylate cardiac troponin. PKCα is implicated in heart failure and serves as a potential therapeutic target, however, the exact consequences for contractile function in
Externí odkaz:
https://doaj.org/article/4aabed2ccc354eed92d2625701fe7899
Autor:
Jolanda evan der Velden, Daphne eMerkus, Vincent ede Beer, Nazha eHamdani, Wolfgang eLinke, Nicky M Boontje, Ger JM Stienen, Dirk J Duncker
Publikováno v:
Frontiers in Physiology, Vol 2 (2011)
Transmural differences in sarcomeric protein composition and function across the left ventricular (LV) wall have been reported. We studied sarcomeric function and protein phosphorylation in subepicardial (EPI) and subendocardial (ENDO) layers of remo
Externí odkaz:
https://doaj.org/article/c7308cd87c3e4642a5fe5cc2f2348522
Autor:
Sabine J. van Dijk, Michelle Michels, Folkert J. ten Cate, Dennis Dooijes, Cris dos Remedios, Ger J.M. Stienen, Marjon van Slegtenhorst, Jolanda van der Velden, Nicky M. Boontje, Martijn W. Heymans
Publikováno v:
van Dijk, S J, Boontje, N M, Heymans, M W, ten Cate, F J, Michels, M, dos Remedios, C, Dooijes, D, van Slegtenhorst, M A, van der Velden, J & Stienen, G J M 2014, ' Preserved cross-bridge kinetics in human hypertrophic cardiomyopathy patients with MYBPC3 mutations ', Pflügers Archiv European Journal of Physiology, vol. 466, no. 8, pp. 1619-1633 . https://doi.org/10.1007/s00424-013-1391-0
Pflugers Archiv-European Journal of Physiology, 466(8), 1619-1633. Springer-Verlag
Pflügers Archiv European Journal of Physiology, 466(8), 1619-1633. Springer Verlag
Pflugers Archiv-European Journal of Physiology, 466(8), 1619-1633. Springer-Verlag
Pflügers Archiv European Journal of Physiology, 466(8), 1619-1633. Springer Verlag
Mutations in the MYBPC3 gene, encoding cardiac myosin binding protein C (cMyBP-C) are frequent causes of hypertrophic cardiomyopathy (HCM). Previously, we have presented evidence for reduced cMyBP-C expression (haploinsufficiency), in patients with a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07e8aa0b933c18001a09441afc57e34b
https://hdl.handle.net/1871.1/feda07a6-2c6c-4060-bb46-8cece0bd7443
https://hdl.handle.net/1871.1/feda07a6-2c6c-4060-bb46-8cece0bd7443
Autor:
Nicky M. Boontje, Robert Passier, Paul Steendijk, Jolanda van der Velden, Willemijn van Eldik, Ingeborg van der Made, Christine L. Mummery, Esther E. Creemers, Norbert Frey, Derk Frank, Jantine Monshouwer-Kloots, Abdelaziz Beqqali, Saskia Maas, Brigit den Adel, Daniela C.F. Salvatori
Publikováno v:
PLoS ONE, 12(12):e0189139. Public Library of Science
PLoS ONE, 12(12)
PLoS ONE
PLoS ONE, Vol 12, Iss 12, p e0189139 (2017)
Van Eldik, W, Den Adel, B, Monshouwer-kloots, J, Salvatori, D, Maas, S, Van Der Made, I, Creemers, E E, Frank, D, Frey, N, Boontje, N, Van Der Velden, J, Steendijk, P, Mummery, C, Passier, R & Beqqali, A 2017, ' Z-disc protein CHAPb induces cardiomyopathy and contractile dysfunction in the postnatal heart ', PLoS ONE, vol. 12, no. 12, pp. e0189139 . https://doi.org/10.1371/journal.pone.0189139
Van Eldik, W, Den Adel, B, Monshouwer-Kloots, J, Salvatori, D, Maas, S, Van Der Made, I, Creemers, E E, Frank, D, Frey, N, Boontje, N, Van Der Velden, J, Steendijk, P, Mummery, C, Passier, R & Beqqali, A 2017, ' Z-disc protein CHAPb induces cardiomyopathy and contractile dysfunction in the postnatal heart ', PLoS ONE, vol. 12, no. 12, e0189139 . https://doi.org/10.1371/journal.pone.0189139
PLoS ONE, 12(12)
PLoS ONE
PLoS ONE, Vol 12, Iss 12, p e0189139 (2017)
Van Eldik, W, Den Adel, B, Monshouwer-kloots, J, Salvatori, D, Maas, S, Van Der Made, I, Creemers, E E, Frank, D, Frey, N, Boontje, N, Van Der Velden, J, Steendijk, P, Mummery, C, Passier, R & Beqqali, A 2017, ' Z-disc protein CHAPb induces cardiomyopathy and contractile dysfunction in the postnatal heart ', PLoS ONE, vol. 12, no. 12, pp. e0189139 . https://doi.org/10.1371/journal.pone.0189139
Van Eldik, W, Den Adel, B, Monshouwer-Kloots, J, Salvatori, D, Maas, S, Van Der Made, I, Creemers, E E, Frank, D, Frey, N, Boontje, N, Van Der Velden, J, Steendijk, P, Mummery, C, Passier, R & Beqqali, A 2017, ' Z-disc protein CHAPb induces cardiomyopathy and contractile dysfunction in the postnatal heart ', PLoS ONE, vol. 12, no. 12, e0189139 . https://doi.org/10.1371/journal.pone.0189139
Aims The Z-disc is a crucial structure of the sarcomere and is implicated in mechanosensation/transduction. Dysregulation of Z-disc proteins often result in cardiomyopathy. We have previously shown that the Z-disc protein Cytoskeletal Heart-enriched
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15f32116f65c1f84258a85803ec1465b
https://doi.org/10.1371/journal.pone.0189139
https://doi.org/10.1371/journal.pone.0189139
Autor:
Folkert J. ten Cate, Jolanda van der Velden, Lucie Carrier, Marjon van Slegtenhorst, Cris dos Remedios, Dennis Dooijes, Sakthivel Sadayappan, Michelle Michels, E. Rosalie Paalberends, Aref Najafi, Nicky M. Boontje, Ger J.M. Stienen, Diederik W. D. Kuster, Sabine J. van Dijk
Publikováno v:
Circulation: Heart Failure
Circulation-Heart Failure, 5(1), 36-U126. Lippincott Williams & Wilkins
Circulation. Heart failure, 5(1), 36-U126. Lippincott Williams and Wilkins
van Dijk, S J, Paalberends, E R, Najafi, A, Michels, M, Sadayappan, S, Carrier, L, Boontje, N M, Kuster, D W D, van Slegtenhorst, M, Dooijes, D, dos Remedios, C, ten Cate, F J, Stienen, G J M & van der Velden, J 2012, ' Contractile Dysfunction Irrespective of the Mutant Protein in Human Hypertrophic Cardiomyopathy With Normal Systolic Function ', Circulation. Heart failure, vol. 5, no. 1, pp. 36-U126 . https://doi.org/10.1161/CIRCHEARTFAILURE.111.963702
Circulation: Heart Failure; Vol 5
Circulation-Heart Failure, 5(1), 36-U126. Lippincott Williams & Wilkins
Circulation. Heart failure, 5(1), 36-U126. Lippincott Williams and Wilkins
van Dijk, S J, Paalberends, E R, Najafi, A, Michels, M, Sadayappan, S, Carrier, L, Boontje, N M, Kuster, D W D, van Slegtenhorst, M, Dooijes, D, dos Remedios, C, ten Cate, F J, Stienen, G J M & van der Velden, J 2012, ' Contractile Dysfunction Irrespective of the Mutant Protein in Human Hypertrophic Cardiomyopathy With Normal Systolic Function ', Circulation. Heart failure, vol. 5, no. 1, pp. 36-U126 . https://doi.org/10.1161/CIRCHEARTFAILURE.111.963702
Circulation: Heart Failure; Vol 5
Background— Hypertrophic cardiomyopathy (HCM), typically characterized by asymmetrical left ventricular hypertrophy, frequently is caused by mutations in sarcomeric proteins. We studied if changes in sarcomeric properties in HCM depend on the under
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9a84e6e3f64373a1080cbfa3122d15e
https://doi.org/10.1161/CIRCHEARTFAILURE.111.963702
https://doi.org/10.1161/CIRCHEARTFAILURE.111.963702
Autor:
Max Goebel, R. Zaremba, Diederik W. D. Kuster, Nicky M. Boontje, Jolanda van der Velden, Amira Cholid Bawazeer
Publikováno v:
Journal of Muscle Research and Cell Motility
Kuster, D W D, Bawazeer, A C, Zaremba, R, Goebel, M, Boontje, N & van der Velden, J 2012, ' Cardiac myosin binding protein C phosphorylation in cardiac disease ', Journal of Muscle Research and Cell Motility, vol. 33, no. 1, pp. 43-52 . https://doi.org/10.1007/s10974-011-9280-7
Journal of Muscle Research and Cell Motility; Vol 33
Journal of Muscle Research and Cell Motility, 33(1), 43-52. Springer Netherlands
Kuster, D W D, Bawazeer, A C, Zaremba, R, Goebel, M, Boontje, N & van der Velden, J 2012, ' Cardiac myosin binding protein C phosphorylation in cardiac disease ', Journal of Muscle Research and Cell Motility, vol. 33, no. 1, pp. 43-52 . https://doi.org/10.1007/s10974-011-9280-7
Journal of Muscle Research and Cell Motility; Vol 33
Journal of Muscle Research and Cell Motility, 33(1), 43-52. Springer Netherlands
Perturbations in sarcomeric function may in part underlie systolic and diastolic dysfunction of the failing heart. Sarcomeric dysfunction has been ascribed to changes in phosphorylation status of sarcomeric proteins caused by an altered balance betwe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fabb62bea915b15c1c2a20604872dc9
http://europepmc.org/articles/PMC3351594
http://europepmc.org/articles/PMC3351594
Autor:
Diederik W. D. Kuster, Dirk J. Duncker, Patricia Holemans, Nicky M. Boontje, Karin R. Sipido, Jolanda van der Velden, Martine de Boer, Elza D. van Deel
Publikováno v:
Journal of Molecular and Cellular Cardiology, 50(6), 1017-1025. Academic Press Inc.
Journal of Molecular and Cellular Cardiology, 50(6), 1017-1025. Academic Press
van Deel, E D, de Boer, M, Kuster, D W D, Boontje, N M, Holemans, P, Sipido, K R, van der Velden, J & Duncker, D J 2011, ' Exercise training does not improve cardiac function in compensated or decompensated left ventricular hypertrophy induced by aortic stenosis ', Journal of Molecular and Cellular Cardiology, vol. 50, no. 6, pp. 1017-1025 . https://doi.org/10.1016/j.yjmcc.2011.01.016
Journal of Molecular and Cellular Cardiology, 50(6), 1017-1025. Academic Press
van Deel, E D, de Boer, M, Kuster, D W D, Boontje, N M, Holemans, P, Sipido, K R, van der Velden, J & Duncker, D J 2011, ' Exercise training does not improve cardiac function in compensated or decompensated left ventricular hypertrophy induced by aortic stenosis ', Journal of Molecular and Cellular Cardiology, vol. 50, no. 6, pp. 1017-1025 . https://doi.org/10.1016/j.yjmcc.2011.01.016
There is ample evidence that regular exercise exerts beneficial effects on left ventricular (LV) hypertrophy, remodeling and dysfunction produced by ischemic heart disease or systemic hypertension. In contrast, the effects of exercise on pathological
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33aad9ed6d26571e5bb7878e5b62b884
https://doi.org/10.1016/j.yjmcc.2011.01.016
https://doi.org/10.1016/j.yjmcc.2011.01.016
Autor:
Daphne Merkus, Lori A. Walker, Vincent J. de Beer, Dirk J. Duncker, R. Zaremba, Hans W.M. Niessen, Ger J.M. Stienen, Jolanda van der Velden, Monique C. de Waard, Dobromir Dobrev, Nicky M. Boontje, Lucie Carrier, Giulia Mearini, Amanda M. G. Versteilen
Publikováno v:
Boontje, N, Merkus, D, Zaremba, R, Versteilen, A M G, de Waard, M, Mearini, G, de Beer, V J, Carrier, L, Walker, L A, Niessen, H W M, Dobrev, D, Stienen, G J M, Duncker, D J & van der Velden, J 2011, ' Enhanced myofilament responsiveness upon β-adrenergic stimulation in post-infarct remodeled myocardium. ', Journal of Molecular and Cellular Cardiology, vol. 50, pp. 487-499 . https://doi.org/10.1016/j.yjmcc.2010.12.002
Journal of Molecular and Cellular Cardiology, 50, 487-499. Academic Press Inc.
Journal of Molecular and Cellular Cardiology, 50(3), 487-499. Academic Press
Journal of Molecular and Cellular Cardiology, 50, 487-499. Academic Press Inc.
Journal of Molecular and Cellular Cardiology, 50(3), 487-499. Academic Press
Previously we showed that left ventricular (LV) responsiveness to exercise-induced increases in noradrenaline was blunted in pigs with a recent myocardial infarction (MI) [van der Velden et al. Circ Res. 2004], consistent with perturbed beta-adrenerg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e29ab50c272777d8c97ed46d795b2d4e
https://hdl.handle.net/1871/36120
https://hdl.handle.net/1871/36120
Autor:
Nicky M. Boontje, Viola Kooij, Kornelia Jaquet, Ger J.M. Stienen, Cris dos Remedios, Jolanda van der Velden, R. Zaremba
Publikováno v:
Basic Research in Cardiology
Basic Research in Cardiology, 105(2), 289-300. D. Steinkopff-Verlag
Kooij, V, Boontje, N, Zaremba, R, Jaquet, K, dos Remedios, C, Stienen, G J M & van der Velden, J 2010, ' Protein kinase C alpha and epsilon phosphorylation of troponin and myosin binding protein C reduce Ca2+ sensitivity in human myocardium ', Basic Research in Cardiology, vol. 105, no. 2, pp. 289-300 . https://doi.org/10.1007/s00395-009-0053-z
Basic Research in Cardiology, 105(2), 289-300. D. Steinkopff-Verlag
Kooij, V, Boontje, N, Zaremba, R, Jaquet, K, dos Remedios, C, Stienen, G J M & van der Velden, J 2010, ' Protein kinase C alpha and epsilon phosphorylation of troponin and myosin binding protein C reduce Ca2+ sensitivity in human myocardium ', Basic Research in Cardiology, vol. 105, no. 2, pp. 289-300 . https://doi.org/10.1007/s00395-009-0053-z
Previous studies indicated that the increase in protein kinase C (PKC)-mediated myofilament protein phosphorylation observed in failing myocardium might be detrimental for contractile function. This study was designed to reveal and compare the effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38b2eba6800515744dc471ecfae6192f
https://doi.org/10.1007/s00395-009-0053-z
https://doi.org/10.1007/s00395-009-0053-z
Autor:
Rien van Haperen, Dirk J. Duncker, Jos M. J. Lamers, Nicky M. Boontje, Jolanda van der Velden, Monique C. de Waard, Rini de Crom, Dick H. W. Dekkers, Diederik W. D. Kuster
Publikováno v:
American Journal of Physiology. Heart and Circulatory Physiology, 296(5), H1513-H1523. American Physiological Society
American Journal of Physiology-Heart and Circulatory Physiology, 296(5), H1513-H1523. American Physiological Society
de Waard, M, van der Velden, J, Boontje, N, Dekkers, D, van Haperen, R, Kuster, D W D, Lamers, J M J, de Crom, R & Duncker, D J 2009, ' Detrimental effect of combined exercise training and eNOS overexpression on cardiac function after myocardial infarction ', American Journal of Physiology. Heart and Circulatory Physiology, vol. 296, no. 5, pp. H1513-H1523 . https://doi.org/10.1152/ajpheart.00485.2008
American Journal of Physiology-Heart and Circulatory Physiology, 296(5), H1513-H1523. American Physiological Society
de Waard, M, van der Velden, J, Boontje, N, Dekkers, D, van Haperen, R, Kuster, D W D, Lamers, J M J, de Crom, R & Duncker, D J 2009, ' Detrimental effect of combined exercise training and eNOS overexpression on cardiac function after myocardial infarction ', American Journal of Physiology. Heart and Circulatory Physiology, vol. 296, no. 5, pp. H1513-H1523 . https://doi.org/10.1152/ajpheart.00485.2008
de Waard MC, van der Velden J, Boontje NM, Dekkers DH, van Haperen R, Kuster DW, Lamers JM, de Crom R, Duncker DJ. Detrimental effect of combined exercise training and eNOS overexpression on cardiac function after myocardial infarction. Am J Physiol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e68ff42b2399894295ba8dfbf2b2ab5
https://doi.org/10.1152/ajpheart.00485.2008
https://doi.org/10.1152/ajpheart.00485.2008