Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Nicky Hood"'
Autor:
Kathleen I. Pritchard, Marguerite Ennis, Jarley Koo, Nicky Hood, Sara Kristina Taylor, Maureen E. Trudeau, Pamela J. Goodwin
Publikováno v:
Journal of Clinical Oncology. 30:164-171
Purpose To investigate patterns of prognostic associations over time of insulin- and obesity-related variables measured at diagnosis of early breast cancer (BC), focusing on whether the prognostic associations with distant recurrence and death change
Publikováno v:
Journal of Clinical Oncology. 27:3757-3763
Purpose Vitamin D has been linked to breast cancer risk, but prognostic effects are unknown. Such effects are biologically plausible given the presence of vitamin D receptors in breast cancer cells, which act as nuclear transcription factors to regul
Autor:
Pamela J. Goodwin, Marguerite Ennis, Kathleen I. Pritchard, Maureen E. Trudeau, Jarley Koo, Yolanda Madarnas, Warren Hartwick, Barry Hoffman, Nicky Hood
Publikováno v:
Journal of Clinical Oncology. 20:42-51
PURPOSE: Insulin, a member of a family of growth factors that includes insulin-like growth factor (IGF)-I and IGF-II, exerts mitogenic effects on normal and malignant breast epithelial cells, acting via insulin and IGF-I receptors. Because of this an
Autor:
Pamela J. Goodwin, Molyn Leszcz, Marguerite Ennis, Jan Koopmans, Leslie Vincent, Helaine Guther, Elaine Drysdale, Marilyn Hundleby, Harvey M. Chochinov, Margaret Navarro, Michael Speca, Julia Masterson, Liz Dohan, Rami Sela, Barbara Warren, Alexander Paterson, Kathleen I. Pritchard, Andrew Arnold, Richard Doll, Susan E. O'Reilly, Gail Quirt, Nicky Hood, Jonathan Hunter
Publikováno v:
New England Journal of Medicine. 345:1719-1726
Supportive-expressive group therapy has been reported to prolong survival among women with metastatic breast cancer. However, in recent studies, various psychosocial interventions have not prolonged survival.In a multicenter trial, we randomly assign
Autor:
David R. McCready, Wey Liang Leong, Marguerite Ennis, Michael Reedijk, Susan J. Done, Vuk Stambolic, Pamela J. Goodwin, Ryan J.O. Dowling, Nicky Hood, Jaime Escallon, Martin C. Chang, Saroj Niraula
Publikováno v:
Breast cancer research and treatment. 135(3)
Metformin may exert anti-cancer effects through indirect (insulin-mediated) or direct (insulin-independent) mechanisms. We report results of a neoadjuvant “window of opportunity” study of metformin in women with operable breast cancer. Newly diag
Autor:
Marguerite Ennis, I. George Fantus, Pamela J. Goodwin, Mala Bahl, Maureen E. Trudeau, Jarley Koo, Nicky Hood, Kathleen I. Pritchard
Publikováno v:
Breast cancer research and treatment. 114(3)
Background High insulin levels have been associated with poor outcomes in breast cancer. Our goal was to investigate whether hyperinsulinemia was associated with insulin resistance in a cohort of newly diagnosed locoregional breast cancer patients an
Autor:
Frances P. O'Malley, Julia A. Knight, Pamela J. Goodwin, Marguerite Ennis, Irene L. Andrulis, Jane C. Figueiredo, John R. McLaughlin, Nicky Hood
Publikováno v:
Breast cancer research and treatment. 105(1)
The objective of this study was to examine the association of: (i) diagnosis at age/=35, (ii) first-degree family history of breast or ovarian cancer (BOC) and (iii) a research based definition of genetic risk, with tumor characteristics, treatment a
Autor:
Marguerite Ennis, I. George Fantus, Pamela J. Goodwin, Maureen E. Trudeau, Jarley Koo, Nicky Hood, Kathleen I. Pritchard
Publikováno v:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 23(25)
Purpose Leptin, an adipocyte-derived cytokine that is elevated in obesity, has been associated with carcinogenesis, tumor migration and invasion, enhancement of angiogenesis, and increased aromatase activity. It has been suggested that leptin may med
Autor:
Jarley Koo, Nicky Hood, Marguerite Ennis, Kathleen I. Pritchard, Pamela J. Goodwin, Maureen E. Trudeau, Louise Bordeleau
Publikováno v:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 22(20)
Purpose Evidence that psychosocial status and health-related quality of life (HRQOL) are associated with breast cancer (BC) outcomes is weak and inconsistent. We examined prognostic effects of these factors in a prospective cohort study. Patients and
Autor:
Marguerite Ennis, Kathleen I. Pritchard, Maureen E. Trudeau, Jarley Koo, Nicky Hood, Pamela J. Goodwin
Publikováno v:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 21(13)
Purpose: Diet has been postulated to influence breast cancer prognosis; however, existing evidence is weak and inconsistent. Previous studies have sought evidence of a linear relationship between diet and breast cancer outcomes. Because of a U-shaped