A Rubisco-binding protein is required for normal pyrenoid number and starch sheath morphology in Chlamydomonas reinhardtii

Autor: Alan K. Itakura, Leif J. Pallesen, Lianyong Wang, Oliver D Caspari, Robyn Roth, Weronika Patena, Alistair J. McCormick, Howard Griffiths, Kher Xing Chan, Ursula Goodenough, Nicky Atkinson, Martin C. Jonikas, Gregory Reeves

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Itakura, A K, Chan, K X, Atkinson, N, Pallesen, L, Wang, L, Reeves, G, Patena, W, Caspari, O, Roth, R, Goodenough, U, McCormick, A J, Griffiths, H & Jonikas, M C 2019, ' A Rubisco-binding protein is required for normal pyrenoid number and starch sheath morphology in Chlamydomonas reinhardtii ', Proceedings of the National Academy of Sciences, vol. 116, no. 37, pp. 18445-18454 . https://doi.org/10.1073/pnas.1904587116

Significance Many cellular structures are assembled via phase separation, forming liquid-like droplets in a manner analogous to oil in water. How can the cell control whether there is 1 droplet or many? Here, we provide insights into this question by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7be7ff60b6ff73a5ca5f126d6bd9757d
https://doi.org/10.1073/pnas.1904587116

Condensation of Rubisco into a proto-pyrenoid in higher plant chloroplasts

Autor: Yuwei Mao, Alistair J. McCormick, Nicky Atkinson, Kher Xing Chan

Publikováno v: Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Atkinson, N, Mao, Y, Chan, K X & McCormick, A J 2020, ' Condensation of rubisco into a proto-pyrenoid in higher plant chloroplasts ', Nature Communications, vol. 11, no. 1, 6303 . https://doi.org/10.1038/s41467-020-20132-0

Photosynthetic CO2 fixation in plants is limited by the inefficiency of the CO2-assimilating enzyme Rubisco. In most eukaryotic algae, Rubisco aggregates within a microcompartment known as the pyrenoid, in association with a CO2-concentrating mechani

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cecee51c4d6e10f83666f6ecf86341a
https://doi.org/10.1038/s41467-020-20132-0

Progress and challenges of engineering a biophysical CO2-concentrating mechanism into higher plants

Autor: Benedict M. Long, Benjamin D. Rae, Wei Yih Hee, Britta Förster, Christos N. Velanis, Nicky Atkinson, G. Dean Price, Bratati Mukherjee, Alistair J. McCormick, Nghiem D. Nguyen

Publikováno v: Journal of Experimental Botany. 68:3717-3737

Growth and productivity in important crop plants is limited by the inefficiencies of the C3 photosynthetic pathway. Introducing CO2-concentrating mechanisms (CCMs) into C3 plants could overcome these limitations and lead to increased yields. Many uni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01376a16188d1294925a65180c36e611
https://doi.org/10.1093/jxb/erx133

Elevation of CpG frequencies in influenza A genome attenuates pathogenicity but enhances host response to infection

Autor: Marlynne Q. Nicol, Paul Klenerman, Lian Ni Lee, Andrew J Highton, Bernadette M. Dutia, Paul Digard, Helen M. Wise, Nicky Atkinson, Huayu Zhang, Philippa M. Beard, Peter Simmonds, Eleanor R. Gaunt

Publikováno v: Gaunt, E, Wise, H M, Zhang, H, Lee, L N, Atkinson, N J, Nicol, M Q, Highton, A J, Klenerman, P, Beard, P M, Dutia, B M, Digard, P & Simmonds, P 2016, ' Elevation of CpG frequencies in influenza A genome attenuates pathogenicity but enhances host response to infection ', eLIFE, vol. 5, e12735 . https://doi.org/10.7554/eLife.12735
eLife
eLife, Vol 5 (2016)

Previously, we demonstrated that frequencies of CpG and UpA dinucleotides profoundly influence the replication ability of echovirus 7 (Tulloch et al., 2014). Here, we show that that influenza A virus (IAV) with maximised frequencies of these dinucleo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2a96e09046f64e1119fe3bb85449148
https://www.pure.ed.ac.uk/ws/files/23761805/elife_12735_v2.pdf

RNA virus attenuation by codon pair deoptimisation is an artefact of increases in CpG/UpA dinucleotide frequencies

Autor: Fiona Tulloch, Nicky Atkinson, Peter Simmonds, Martin D. Ryan, David J.A. Evans

Publikováno v: eLife, Vol 3 (2014)
Tulloch, F, Atkinson, N J, Evans, D J, Ryan, M D & Simmonds, P 2014, ' RNA virus attenuation by codon pair deoptimisation is an artefact of increases in CpG/UpA dinucleotide frequencies ', eLIFE, vol. 3 . https://doi.org/10.7554/eLife.04531
eLife

Mutating RNA virus genomes to alter codon pair (CP) frequencies and reduce translation efficiency has been advocated as a method to generate safe, attenuated virus vaccines. However, selection for disfavoured CPs leads to unintended increases in CpG

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc5cfeb6ca58ad6302f19b20432e1fb8
https://hdl.handle.net/10023/5998