Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Nicky Akbarian"'
Autor:
Ninoschka C. D’Souza, Julian A. Aiken, Emily G. Hoffman, Sara C. Atherley, Sabrina Champsi, Nadia Aleali, Dorsa Shakeri, Maya El-Zahed, Nicky Akbarian, Mehran Nejad-Mansouri, Parinaz Z. Bavani, Richard L. Liggins, Owen Chan, Michael C. Riddell
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Background: Elevated levels of somatostatin blunt glucagon counterregulation during hypoglycemia in type 1 diabetes (T1D) and this can be improved using somatostatin receptor 2 (SSTR2) antagonists. Hypoglycemia also occurs in late-stage type 2 diabet
Externí odkaz:
https://doaj.org/article/d6004c849ef2466b9d45505754e327f6
Autor:
EMILY G. HOFFMAN, SARA C. ATHERLEY, NICKY AKBARIAN, NINOSCHKA DSOUZA, RICHARD LIGGINS, MICHAEL RIDDELL
Publikováno v:
Diabetes. 71
Background: Pancreatic islet remodelling in type 1 diabetes increases somatostatin (SST) expression, which inhibits glucagon counterregulation to hypoglycemia. Here, we characterized islet morphology and hormone composition in a rodent model of insul