Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Nickolas Tsakmaklis"'
Autor:
Xia Liu, Jiaji G. Chen, Manit Munshi, Zachary R. Hunter, Lian Xu, Amanda Kofides, Nickolas Tsakmaklis, Maria G. Demos, Maria Luisa Guerrera, Gloria G. Chan, Cristina Jimenez, Christopher J. Patterson, Kirsten Meid, Andrew Keezer, Jorge J. Castillo, Steven P. Treon, Guang Yang
Publikováno v:
Blood Advances, Vol 4, Iss 1, Pp 141-153 (2020)
Abstract: Hematopoietic cell kinase (HCK) is an SRC family member that is aberrantly upregulated in B-cell neoplasms dependent on MYD88-activating mutations and supports their growth and survival. We showed herein that activation of Toll-like recepto
Externí odkaz:
https://doaj.org/article/f0c549eb05534163bf4e7c11455f1321
Autor:
Maria Luisa Guerrera, Nickolas Tsakmaklis, Lian Xu, Guang Yang, Maria Demos, Amanda Kofides, Gloria G. Chan, Robert J. Manning, Xia Liu, Jiaji G. Chen, Manit Munshi, Christopher J. Patterson, Jorge J. Castillo, Toni Dubeau, Joshua Gustine, Ruben D. Carrasco, Luca Arcaini, Marzia Varettoni, Mario Cazzola, Steven P. Treon, Zachary R. Hunter
Publikováno v:
Haematologica, Vol 103, Iss 9 (2018)
Externí odkaz:
https://doaj.org/article/2dd51763f66444f692f0788be558c7a4
Autor:
Josephine M. Vos, Nickolas Tsakmaklis, Christopher J. Patterson, Kirsten Meid, Jorge J. Castillo, Philip Brodsky, Tomas Ganz, Steven T. Pals, Marie José Kersten, Lian Xu, Guang Yang, Steven P. Treon, Zachary R. Hunter
Publikováno v:
Haematologica, Vol 102, Iss 11 (2017)
Externí odkaz:
https://doaj.org/article/4a84a9fffe8842bbaa438a5fc0067925
Autor:
Zachary R Hunter, Nickolas Tsakmaklis, Kris Richardson, Maria Luisa Guerrera, Amanda Kofides, Xia Liu, Shirong Liu, Alexa Canning, Manit Munshi, Shayna Sarosiek, Catherine A. Flynn, Andrew R. Branagan, Lian Xu, Guang Yang, Kirsten Meid, Joshua Gustine, Christopher J Patterson, Kenneth C. Anderson, Nikhil C Munshi, Jorge J. Castillo, Steven P Treon
Publikováno v:
Blood. 140:1740-1741
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ec9542f4767a731ead6f71f9a132593
https://doi.org/10.1182/blood-2022-170412
https://doi.org/10.1182/blood-2022-170412
Autor:
Kris Richardson, Jorge J. Castillo, Shayna Sarosiek, Andrew R. Branagan, Catherine A. Flynn, Kirsten Meid, Carly Leventoff, Timothy P White, Megan Little, Joshua Gustine, Xia Liu, Amanda Kofides, Shirong Liu, Alexa Canning, Julie Wolf, Katherine Kacena, Christopher J Patterson, Maria Luisa Guerrera, Nickolas Tsakmaklis, Steven P Treon, Zachary R Hunter
Publikováno v:
Blood. 140:3541-3542
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::443f76c48f353bdab39e15002b1c401e
https://doi.org/10.1182/blood-2022-170254
https://doi.org/10.1182/blood-2022-170254
Autor:
Jorge J. Castillo, Lian Xu, Maria Demos, Guang Yang, Christopher J. Patterson, Amanda Kofides, Xia Liu, Cristina Jimenez, Manit Munshi, Steven P. Treon, Jiaji G. Chen, Maria Luisa Guerrera, Gloria Chan, Zachary R. Hunter, Nickolas Tsakmaklis
Publikováno v:
Blood Adv
Key Points Single-cell whole-genome amplification can be used to interrogate the genomic architecture of Waldenström’s macroglobulinemia. The mutational signature of CXCR4MUT cells may be associated with alterations in DNA repairing genes and tumo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e53399b15dbb1d9102e32b16afdd7401
https://doi.org/10.1182/bloodadvances.2020001775
https://doi.org/10.1182/bloodadvances.2020001775
Autor:
Maria Luisa Guerrera, Xia Liu, Nickolas Tsakmaklis, Andrew Keezer, Jiaji G. Chen, Cristina Jimenez, Kirsten Meid, Christopher J. Patterson, Guang Yang, Manit Munshi, Maria Demos, Amanda Kofides, Lian Xu, Steven P. Treon, Jorge J. Castillo, Gloria Chan, Zachary R. Hunter
Publikováno v:
Blood Advances. 4:141-153
Hematopoietic cell kinase (HCK) is an SRC family member that is aberrantly upregulated in B-cell neoplasms dependent on MYD88-activating mutations and supports their growth and survival. We showed herein that activation of Toll-like receptor (TLR) si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90a408fefd71acd0a0cacc97ae160d82
https://doi.org/10.1182/bloodadvances.2019000947
https://doi.org/10.1182/bloodadvances.2019000947
Autor:
Manit Munshi, Xia Liu, Amanda Kofides, Nickolas Tsakmaklis, Maria Luisa Guerrera, Zachary R. Hunter, M. Lia Palomba, Kimon V. Argyropoulos, Christopher J. Patterson, Alexa G. Canning, Kirsten Meid, Joshua Gustine, Andrew R. Branagan, Catherine A. Flynn, Shayna Sarosiek, Jorge J. Castillo, Jinhua Wang, Sara J. Buhrlage, Nathanael S. Gray, Nikhil C. Munshi, Kenneth C. Anderson, Steven P. Treon, Guang Yang
Publikováno v:
Blood advances. 6(11)
The SRC family kinase (SFK) HCK is transcriptionally upregulated and activated by mutated MYD88 (MYD88Mut), a key adaptor for Toll-receptor signaling. HCK activates BTK, AKT, and ERK in MYD88Mut lymphomas. SYK, a B-cell receptor (BCR) component, is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::505244d02f397364db9d35d139b761c9
https://pubmed.ncbi.nlm.nih.gov/35255496
https://pubmed.ncbi.nlm.nih.gov/35255496
Autor:
Jorge J. Castillo, Maria Lia Palomba, Steven P. Treon, Morie A. Gertz, Prashant Kapoor, Xia Liu, Manit Munshi, Amanda Kofides, Kirsten Mein, Maria Luisa Guerrera, Joshua Gustine, Guang Yang, Stephen M. Ansell, Ranjana H. Advani, Maria Demos, Jithma P. Abeykoon, Saurabh Zanwar, Catherine A Flynn, Nickolas Tsakmaklis, Rebecca L. King, Zachary R. Hunter
Publikováno v:
British journal of haematology. 192(3)
Ibrutinib is associated with durable responses in patients with Waldenstrom macroglobulinaemia (WM). We hypothesized that response depth is predictive of progression-free survival (PFS) in WM patients treated with ibrutinib. Using landmark analyses,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66ca05e1b2d973e9adb358faaf567ddc
https://pubmed.ncbi.nlm.nih.gov/33206997
https://pubmed.ncbi.nlm.nih.gov/33206997
SYK is activated by mutated MYD88 and drives pro-survival signaling in MYD88 driven B-cell lymphomas
Autor:
Sara J. Buhrlage, Jorge J. Castillo, Andrew Keezer, Manit Munshi, Kimon V. Argyropoulos, Lian Xu, M. Lia Palomba, Nathanael S. Gray, Maria Luisa Guerrera, Jinhua Wang, Gloria Chan, Christopher J. Patterson, Xia Liu, Amanda Kofides, Nickolas Tsakmaklis, Joshua Gustine, Cristina Jimenez, Maria Demos, Kirsten Meid, Steven P. Treon, Toni Dubeau, Zachary R. Hunter, Guang Yang, Jiaji G. Chen
Publikováno v:
Blood Cancer Journal
Blood Cancer Journal, Vol 10, Iss 1, Pp 1-11 (2020)
Blood Cancer Journal, Vol 10, Iss 1, Pp 1-11 (2020)
Activating MYD88 mutations promote pro-survival signaling through BTK and HCK, both targets of ibrutinib. Despite high response rates, complete responses to ibrutinib are lacking, and other MYD88 triggered pro-survival pathways may contribute to prim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::950c1dee85ed60c54c827e8bbae0d368
https://doi.org/10.1038/s41408-020-0277-6
https://doi.org/10.1038/s41408-020-0277-6