Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Nickki, Ottaway"'
Autor:
Susanne Raab, Haiyan Wang, Sabine Uhles, Nadine Cole, Ruben Alvarez-Sanchez, Basil Künnecke, Christoph Ullmer, Hugues Matile, Marc Bedoucha, Roger D. Norcross, Nickki Ottaway-Parker, Diego Perez-Tilve, Karin Conde Knape, Matthias H. Tschöp, Marius C. Hoener, Sabine Sewing
Publikováno v:
Molecular Metabolism, Vol 5, Iss 1, Pp 47-56 (2016)
Objective: Type 2 diabetes and obesity are emerging pandemics in the 21st century creating worldwide urgency for the development of novel and safe therapies. We investigated trace amine-associated receptor 1 (TAAR1) as a novel target contributing to
Externí odkaz:
https://doaj.org/article/ad2d43af62f34cb681ec8b5659f0cd52
Autor:
Chun-Xia Yi, Kristy M Heppner, Henriette Kirchner, Jenny Tong, Maximillian Bielohuby, Bruce D Gaylinn, Timo D Müller, Erin Bartley, Harold W Davis, Yongmei Zhao, Anupama Joseph, Traci Kruthaupt, Nickki Ottaway, Dhiraj Kabra, Kirk M Habegger, Stephen C Benoit, Martin Bidlingmaier, Michael O Thorner, Diego Perez-Tilve, Matthias H Tschöp, Paul T Pfluger
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e32100 (2012)
OBJECTIVE:Ghrelin acylation by ghrelin O-acyltransferase (GOAT) has recently been reported to be essential for the prevention of hypoglycemia during prolonged negative energy balance. Using a unique set of four different genetic loss-of-function mode
Externí odkaz:
https://doaj.org/article/bc467b72b5ea464ba3c01bca6c8e1ed1
Autor:
Basil Künnecke, Marius C. Hoener, Roger David Norcross, Haiyan Wang, Rubén Alvarez-Sánchez, Christoph Ullmer, Susanne Raab, Diego Perez-Tilve, Matthias H. Tschöp, Sabine Sewing, Marc Bedoucha, Hugues Matile, Nadine Cole, Karin Conde Knape, Nickki Ottaway-Parker, Sabine Uhles
Publikováno v:
Molecular Metabolism, Vol 5, Iss 1, Pp 47-56 (2016)
Molecular Metabolism
Mol. Metab. 5, 47-56 (2016)
Molecular Metabolism
Mol. Metab. 5, 47-56 (2016)
Objective Type 2 diabetes and obesity are emerging pandemics in the 21st century creating worldwide urgency for the development of novel and safe therapies. We investigated trace amine-associated receptor 1 (TAAR1) as a novel target contributing to t
Autor:
Cassie Holleman, Darleen A. Sandoval, Jeong-a Kim, Joseph Chabenne, Diego Perez-Tilve, Daniel J. Drucker, Teayoun Kim, Deanna M. Arble, Richard D. DiMarchi, Christine Loyd, Shelly Nason, Kirk M. Habegger, Nickki Ottaway
Publikováno v:
Diabetes
Glucagon receptor (GCGR) agonists cause hyperglycemia but also weight loss. However, GCG-like peptide 1 receptor (GLP1R)/GCGR mixed agonists do not exhibit the diabetogenic effects often attributed to GCGR activity. Thus, we sought to investigate the
Autor:
Nickki Ottaway, Kristy M. Heppner, Jenna Holland, David L. Smiley, Sarah Marks, Richard D. DiMarchi, Diego Perez-Tilve
Publikováno v:
Diabetologia. 58:2124-2132
We assessed the contribution of glucagon-like peptide-1 (GLP-1) receptor (GLP-1R) signalling to thermogenesis induced by high-fat diet (HFD) consumption. Furthermore, we determined whether brown adipose tissue (BAT) activity contributes to weight los
Autor:
Heike Biebermann, Darleen A. Sandoval, Kristy M. Heppner, Kirk M. Habegger, David L. Smiley, Diego Perez-Tilve, Anne Müller, Nickki Ottaway, Paul T. Pfluger, Matthias H. Tschöp, Carolin L. Piechowski, Richard D. DiMarchi, Stephanie Sisley
Publikováno v:
Diabetes; Vol 63
Diabetes
Diabetes
Growth hormone secretagogue receptors (GHSRs) in the central nervous system (CNS) mediate hyperphagia and adiposity induced by acyl ghrelin (AG). Evidence suggests that des-AG (dAG) has biological activity through GHSR-independent mechanisms. We comb
Autor:
Chun-Xia Yi, Sonja C. Schriever, Esther de la Fuente, Beata Legutko, Cristina García-Cáceres, Diego Perez-Tilve, Clarita Mergen, Yuanqing Gao, Jessica A. Filosa, Matthias H. Tschöp, Javier E. Stern, Michael W. Schwartz, Susanne Bour, Joshua P. Thaler, Nickki Ottaway, Randy J. Seeley
Publikováno v:
Glia. 62:17-25
The arcuate nucleus (ARC) of the hypothalamus plays a key role in sensing metabolic feedback and regulating energy homeostasis. Recent studies revealed activation of microglia in mice with high-fat diet (HFD)-induced obesity (DIO), suggesting a poten
Autor:
Sarah Amburgy, Richard D. DiMarchi, Matthias H. Tschöp, Timo D. Müller, Randy J. Seeley, Radhakrishna Krishna, Jenna Holland, Paul T. Pfluger, Christine Raver, Kirk M. Habegger, David A. D'Alessio, Nickki Ottaway, Diego Perez-Tilve, Daniel C. Sweeney, Kristy M. Heppner, Chun-Xia Yi, Henriette Kirchner, Silvana Obici
Publikováno v:
Diabetes
Diabetes, 62(9), 3261-3267. American Diabetes Association Inc.
Diabetes, 62(9), 3261-3267. American Diabetes Association Inc.
Bariatric procedures vary in efficacy, but overall are more effective than behavioral and pharmaceutical treatment. Roux-en-Y gastric bypass causes increased secretion of glucagon-like peptide 1 (GLP-1) and reduces body weight (BW) more than adjustab
Autor:
Max Endele, Sheila Collins, Gayathri Ananthakrishnan, Sang Jun Lee, Kristy M. Heppner, Axel Walch, Diego Perez-Tilve, Martin Jastroch, John R. Speakman, Nakul Bhardwaj, Rebecca Oelkrug, Jenna Holland, Brian Finan, Timo D. Müller, Maarit Lehti, Bill Abplanalp, Kirk M. Habegger, Matthias H. Tschöp, Christine Raver, Jazzmin Hembree, Yu-Hua Tseng, Jorge Moscat, Dhiraj G. Kabra, Paul T. Pfluger, Michaela Aichler, Maria Kutschke, Susanna M. Hofmann, Sonja C. Schriever, Kerstin Stemmer, Maria T. Diaz-Meco, Yuanqing Gao, Daniela Küchler, Nickki Ottaway, Senad Divanovic, Radha Krishna
Publikováno v:
J. Clin. Invest. 123, 469-478 (2013)
The scaffold protein p62 (sequestosome 1; SQSTM1) is an emerging key molecular link among the metabolic, immune, and proliferative processes of the cell. Here, we report that adipocyte-specific, but not CNS-, liver-, muscle-, or myeloid-specific p62-
Autor:
Timo D. Müller, Kirk M. Habegger, Stephen C. Woods, Henriette Kirchner, Diego Perez-Tilve, Paul T. Pfluger, Matthias H. Tschöp, Susanna M. Hofmann, William Abplanalp, Radha Krishna, Antje Fischer-Rosinský, Nickki Ottaway, Elizabeth Donelan, Joachim Spranger, Jazzminn Hembree
Publikováno v:
Diabetes
Although obesity rates are rapidly rising, caloric restriction remains one of the few safe therapies. Here we tested the hypothesis that obesity-associated disorders are caused by increased adipose tissue as opposed to excess dietary lipids. Fat mass