Výsledky vyhledávání - "Nickias Kienle"

Shedding light on the expansion and diversification of the Cdc48 protein family during the rise of the eukaryotic cell

Autor: Dirk Fasshauer, Tobias H. Kloepper, Nickias Kienle

Publikováno v: BMC Evolutionary Biology
BMC evolutionary biology, vol. 16, no. 1, pp. 215

Background A defining feature of eukaryotic cells is the presence of various distinct membrane-bound compartments with different metabolic roles. Material exchange between most compartments occurs via a sophisticated vesicle trafficking system. This

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85ec2287073608b31202ee55d7875166
https://doi.org/10.1186/s12862-016-0790-1

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A Coiled Coil Trigger Site Is Essential for Rapid Binding of Synaptobrevin to the SNARE Acceptor Complex

Autor: Katrin Wiederhold, Dirk Fasshauer, Alexander Stein, Jakob B. Sørensen, Nickias Kienle, Alexander M. Walter, Tobias H. Kloepper

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, vol. 285, no. 28, pp. 21549-21559

Exocytosis from synaptic vesicles is driven by stepwise formation of a tight alpha-helical complex between the fusing membranes. The complex is composed of the three SNAREs: synaptobrevin 2, SNAP-25, and syntaxin 1a. An important step in complex form

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91081c2e04bd539513d33fd9eefec5b3
https://doi.org/10.1074/jbc.m110.105148

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SNAREing the Basis of Multicellularity: Consequences of Protein Family Expansion during Evolution

Autor: Dirk Fasshauer, Tobias H. Kloepper, C. Nickias Kienle

Publikováno v: Molecular Biology and Evolution. 25:2055-2068

Vesicle trafficking between intracellular compartments of eukaryotic cells is mediated by conserved protein machineries. In each trafficking step, fusion of the vesicle with the acceptor membrane is driven by a set of distinctive soluble N-ethylmalei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c26049faa219c1f92e2da82265f499a
https://doi.org/10.1093/molbev/msn151

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Additional file 2: Table S1. of Shedding light on the expansion and diversification of the Cdc48 protein family during the rise of the eukaryotic cell

Autor: Nickias Kienle, Kloepper, Tobias, Fasshauer, Dirk

Repertoire of the Cdc48 family members in selected species representing the different major eukaryotic lineages. The eight different Cdc48 family members are present in most eukaryotic lineages, suggesting that these proteins were present in the last

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Additional file 4: Table S2. of Shedding light on the expansion and diversification of the Cdc48 protein family during the rise of the eukaryotic cell

Autor: Nickias Kienle, Kloepper, Tobias, Fasshauer, Dirk

List of representative species used to calculate the evolutionary trees of the entire Cdc48 family. (DOCX 44 kb)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::998540c645b479b5bbbc6f04a71fd186

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Additional file 9: Table S3. of Shedding light on the expansion and diversification of the Cdc48 protein family during the rise of the eukaryotic cell

Autor: Nickias Kienle, Kloepper, Tobias, Fasshauer, Dirk

Repertoire of Cdc48 in cryptophytes, alveolates, stramenopiles, and haptophytes (CASH lineages) and archaeplastida. A filled black circle denotes the presence of endoplasmic reticulum-associated protein degradation (ERAD) or symbiont-specific ERAD-li

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Untangling the evolution of Rab G proteins: implications of a comprehensive genomic analysis

Autor: Dirk Fasshauer, Tobias H. Klöpper, Nickias Kienle, Sean Munro

Publikováno v: BMC Biology, Vol 10, Iss 1, p 71 (2012)
BMC Biology, vol. 10, no. 1, pp. 71
BMC biology

BackgroundMembrane-bound organelles are a defining feature of eukaryotic cells, and play a central role in most of their fundamental processes. The Rab G proteins are the single largest family of proteins that participate in the traffic between organ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::333bac0e591a551da58c2e70a934bb59
http://www.biomedcentral.com/1741-7007/10/71

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Differences in the SNARE evolution of fungi and metazoa

Autor: Dirk Fasshauer, Nickias Kienle, Tobias H. Kloepper

Publikováno v: Biochemical Society Transactions

Proteins of the SNARE (soluble N-ethylmaleimide-sensitive factor-attachment protein receptor) family are key factors in all vesicle-fusion steps in the endocytic and secretory pathways. SNAREs can assemble into a tight four-helix bundle complex betwe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da43a1d1bfc4cbb2025dbc92ed3fc518
https://hdl.handle.net/11858/00-001M-0000-0012-D7CA-C11858/00-001M-0000-0012-D7C9-E

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Phylogeny of the SNARE vesicle fusion machinery yields insights into the conservation of the secretory pathway in fungi

Autor: Nickias, Kienle, Tobias H, Kloepper, Dirk, Fasshauer

Publikováno v: BMC Evolutionary Biology, Vol 9, Iss 1, p 19 (2009)
BMC Evolutionary Biology

Background In eukaryotic cells, directional transport between different compartments of the endomembrane system is mediated by vesicles that bud from a donor organelle and then fuse with an acceptor organelle. A family of integral membrane proteins,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::2abd7c83b66129b35b2f083a76b11261
http://www.biomedcentral.com/1471-2148/9/19

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An elaborate classification of SNARE proteins sheds light on the conservation of the eukaryotic endomembrane system

Autor: C. Nickias Kienle, Tobias H. Kloepper, Dirk Fasshauer

Publikováno v: Molecular Biology of the Cell

Proteins of the SNARE (soluble N-ethylmalemide–sensitive factor attachment protein receptor) family are essential for the fusion of transport vesicles with an acceptor membrane. Despite considerable sequence divergence, their mechanism of action is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::655574c38cffdd1f783beee13c786647
https://pubmed.ncbi.nlm.nih.gov/17596510

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