Parameter subset reduction for imaging-based digital twin generation of patients with left ventricular mechanical discoordination

Autor: Tijmen Koopsen, Nick van Osta, Tim van Loon, Roel Meiburg, Wouter Huberts, Ahmed S. Beela, Feddo P. Kirkels, Bas R. van Klarenbosch, Arco J. Teske, Maarten J. Cramer, Geertruida P. Bijvoet, Antonius van Stipdonk, Kevin Vernooy, Tammo Delhaas, Joost Lumens

Publikováno v: BioMedical Engineering OnLine, Vol 23, Iss 1, Pp 1-22 (2024)

Abstract Background Integration of a patient’s non-invasive imaging data in a digital twin (DT) of the heart can provide valuable insight into the myocardial disease substrates underlying left ventricular (LV) mechanical discoordination. However, w

Externí odkaz: https://doaj.org/article/890df5f41bbe481a9ef6faafbcaafbb6

Uncertainty Quantification of Regional Cardiac Tissue Properties in Arrhythmogenic Cardiomyopathy Using Adaptive Multiple Importance Sampling

Autor: Nick van Osta, Feddo P. Kirkels, Tim van Loon, Tijmen Koopsen, Aurore Lyon, Roel Meiburg, Wouter Huberts, Maarten J. Cramer, Tammo Delhaas, Kristina H. Haugaa, Arco J. Teske, Joost Lumens

Publikováno v: Frontiers in Physiology, Vol 12 (2021)

Introduction: Computational models of the cardiovascular system are widely used to simulate cardiac (dys)function. Personalization of such models for patient-specific simulation of cardiac function remains challenging. Measurement uncertainty affects

Externí odkaz: https://doaj.org/article/ac762288c42c4d8a9db513426f2bbe28

Parameter subset reduction for patient-specific modelling of arrhythmogenic cardiomyopathy-related mutation carriers in the CircAdapt model

Autor: Aurore Lyon, Nick van Osta, Arco J. Teske, Joost Lumens, Wouter Huberts, Feddo P Kirkels, Tijmen Koopsen, Maarten J. Cramer, Tammo Delhaas, Tim van Loon

Publikováno v: Philosophical transactions. Series A, Mathematical, physical, and engineering sciences
Philosophical Transactions of the Royal Society A: mathematical Physical and Engineering Sciences, 378(2173):20190347. Royal Society of London

Arrhythmogenic cardiomyopathy (AC) is an inherited cardiac disease, clinically characterized by life-threatening ventricular arrhythmias and progressive cardiac dysfunction. Patient-specific computational models could help understand the disease prog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82f9b6557163b315ac8613abd78c92bb
https://doi.org/10.1098/rsta.2019.0347