Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Nick Z. Lu"'
Autor:
Jesus Banuelos, Yun Cao, Soon Cheon Shin, Bruce S Bochner, Pedro Avila, Shihong Li, Xin Jiang, Mark W Lingen, Robert P Schleimer, Nick Z Lu
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0177884 (2017)
Glucocorticoids promote neutrophilic inflammation, the mechanisms of which are poorly characterized. Using a lipopolysaccharide (LPS)-induced acute murine lung injury model, we determined the role of granulocyte colony-stimulating factor (G-CSF) in m
Externí odkaz:
https://doaj.org/article/79a9a2c30c3247119cb5281003bde0e0
Autor:
Nick Z. Lu, Vicki L. Clifton, Zarqa Saif, Karen M. Moritz, Tim J Cole, Peter J. Fuller, Suyinn Chong, James S. M. Cuffe, Sailesh Kumar
Publikováno v:
Placenta. 54:24-29
The physiological mechanisms that confer different outcomes in morbidity and mortality of the fetus exposed to stressful environments may be driven by significant differences in the expression and function of the placental glucocorticoid receptor (GR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfb5d494dc8752e539043264ec3d1b26
https://doi.org/10.1016/j.placenta.2016.12.017
https://doi.org/10.1016/j.placenta.2016.12.017
Publikováno v:
Allergy. 72:331-341
Th17 cells contribute to several inflammatory conditions and increasing evidence supports that Th17 cells are glucocorticoid resistant. However, Th17 cells in psoriasis and related diseases are glucocorticoid sensitive. We compare glucocorticoid sens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04185261d5926e67d03f1138efc04a0f
https://doi.org/10.1111/all.13051
https://doi.org/10.1111/all.13051
Autor:
Julie F. Foley, Jonathan T. Busada, John A. Cidlowski, Nick Z. Lu, Sivapriya Ramamoorthy, Robert H. Oakley
Glucocorticoids are primary stress hormones, and their synthetic derivatives are widely used clinically. The therapeutic efficacy of these steroids is limited by side effects and glucocorticoid resistance. Multiple glucocorticoid receptor (GR) isofor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4704aafe544f3e2a7bf9c99de7c9219d
https://europepmc.org/articles/PMC6133704/
https://europepmc.org/articles/PMC6133704/
A hotspot in the glucocorticoid receptor DNA-binding domain susceptible to loss of function mutation
Publikováno v:
Steroids. 96:115-120
Glucocorticoids (GCs) are used to treat a variety of inflammatory disorders and certain cancers. However, GC resistance occurs in subsets of patients. We found that EL4 cells, a GC-resistant mouse thymoma cell line, harbored a point mutation in their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b24447b6e8c556805240b4234850088e
https://doi.org/10.1016/j.steroids.2015.01.022
https://doi.org/10.1016/j.steroids.2015.01.022
Autor:
Mark W. Lingen, Shihong Li, Soon Cheon Shin, Pedro C. Avila, Xin Jiang, Bruce S. Bochner, Nick Z. Lu, Jesus Banuelos, Robert P. Schleimer, Yun Cao
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0177884 (2017)
PLoS ONE
PLoS ONE
Glucocorticoids promote neutrophilic inflammation, the mechanisms of which are poorly characterized. Using a lipopolysaccharide (LPS)-induced acute murine lung injury model, we determined the role of granulocyte colony-stimulating factor (G-CSF) in m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a81c9ee89edd3ca370a337b270188d8
http://europepmc.org/articles/PMC5438114?pdf=render
http://europepmc.org/articles/PMC5438114?pdf=render
Autor:
Christine M. Jewell, Nick Z. Lu, Ingrid K. Bender, John A. Cidlowski, Yun Cao, Soon Cheon Shin, Athanasios K. Konstantinidis, Robert P. Schleimer
Publikováno v:
Blood. 121:1553-1562
Although glucocorticoids are a profoundly important class of anti-inflammatory and immunosuppressive agents, their actions in dendritic cells (DCs) are not well understood. We found that dexamethasone, a potent glucocorticoid, selectively induced apo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::219554a7e9204f82488c8d38fdbdd6da
https://doi.org/10.1182/blood-2012-05-432336
https://doi.org/10.1182/blood-2012-05-432336
Autor:
G. R. S. Budinger, Jesus Banuelos, S. Li, J. Xin, Luisa Morales-Nebreda, Soon Cheon Shin, Chen Dong, L. Zhou, Mark W. Lingen, Yun Cao, Robert P. Schleimer, Bruce S. Bochner, Nick Z. Lu
Publikováno v:
Allergy. 71(5)
Background Glucocorticoid resistance has been associated with Th17-driven inflammation, the mechanisms of which are not clear. We determined whether human and mouse Th17 cells are resistant to glucocorticoid-induced apoptosis. Methods Freshly isolate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99403390630cef7b94de67d8869734ee
https://pubmed.ncbi.nlm.nih.gov/26752231
https://pubmed.ncbi.nlm.nih.gov/26752231
Autor:
Zarqa Saif, Ian M. R Wright, Nick Z. Lu, Vicki L. Clifton, Rebecca M. Dyson, Hannah K. Palliser
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0148226 (2016)
PLoS ONE
PLoS ONE
The placental glucocorticoid receptor (GR) is central to glucocorticoid signalling and for mediating steroid effects on pathways associated with fetal growth and lung maturation but the GR has not been examined in the guinea pig placenta even though
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bde8b22781e688574d8a0859283e6049
http://europepmc.org/articles/PMC4739593?pdf=render
http://europepmc.org/articles/PMC4739593?pdf=render
Autor:
Nick Z. Lu, Kerry L. Burnstein, Donald P. McDonnell, Peter J. Fuller, John A. Cidlowski, Suzanne E. Wardell, Jack Michel Renoir, Donald B. DeFranco, Elizabeth M. Wilson, Richard B. Hochberg, Vincent Giguère, Lorraine I. McKay, Nancy L. Weigel
Publikováno v:
Pharmacological Reviews. 58:782-797
The glucocorticoid receptor (GR[1][1]), mineralocorticoid receptor (MR), progesterone receptor (PR), and androgen receptor (AR) are classic members of the nuclear receptor superfamily, composing subfamily 3C. Members of this subfamily are among those
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a8eb12213002b4cdae3e23eaf8d33ab
https://doi.org/10.1124/pr.58.4.9
https://doi.org/10.1124/pr.58.4.9