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Autor:
Alec Simpson, Charles E. Wade, Elaine Smith, Amanda Giddings, Ben Bardsley, Clare McKinlay, Angela White, Stephen A. Hermitage, Nick Wooster, James Harvey, Emma Griva, Claire Lesurf, Andrew J. Edwards, Tran N. Pham, Michael Urquhart, Paul Oxley, Fiona King, Stuart G. Leach, Neil G. Stevenson
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 99
The mutagenic-impurity control strategy for a second generation manufacturing route to the non-mutagenic antipneumocystic agent atovaquone (2-((1R,4R)-4-(4-chlorophenyl)cyclohexyl)-3-hydroxynaphthalene-1,4-dione) 1 is described. Preliminary assessmen