Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Nick Van Bruggen"'
Autor:
Yi Liu, Nicolas Basty, Brandon Whitcher, Jimmy D Bell, Elena P Sorokin, Nick van Bruggen, E Louise Thomas, Madeleine Cule
Publikováno v:
eLife, Vol 10 (2021)
Cardiometabolic diseases are an increasing global health burden. While socioeconomic, environmental, behavioural, and genetic risk factors have been identified, a better understanding of the underlying mechanisms is required to develop more effective
Externí odkaz:
https://doaj.org/article/1c20e0199c704b068f9959ba4d108828
Autor:
James J. Lee, Nina Ly, Rejani B. Kunjamma, Holly M. Robb, Eric G. Mohler, Janani Sridar, Qi Hao, José Zavala-Solorio, Chunlian Zhang, Ganesh Kolumam, Nick van Bruggen, Caitlin F. Connelly, Carmela Sidrauski
eIF2B is a decameric guanine nucleotide exchange factor (GEF) that is essential for protein synthesis and a key effector of the integrated stress response (ISR). Hypomorphic mutations in any of the eIF2B subunits are associated with Vanishing White M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a2d80061127e97b50c933f8fc1faa9d
https://doi.org/10.1101/2023.05.06.539602
https://doi.org/10.1101/2023.05.06.539602
Autor:
Deepak Sampath, Jason Oeh, Shelby K. Wyatt, Tim C. Cao, Hartmut Koeppen, Jeffrey Eastham-Anderson, Liliane Robillard, Calvin C.K. Ho, Jed Ross, Guanglei Zhuang, Hani Bou Reslan, Philip Vitorino, Kai H. Barck, Sharon E. Ungersma, Jean Michel Vernes, Maresa Caunt, Nick Van Bruggen, Weilan Ye, Ulka Vijapurkar, Yu-Ju Gloria Meng, Napoleone Ferrara, Lori S. Friedman, Richard A.D. Carano
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 15, Iss 7, Pp 694-711 (2013)
The phosphatidylinositol 3-kinase (PI3K) pathway is a central mediator of vascular endothelial growth factor (VEGF)-driven angiogenesis. The discovery of small molecule inhibitors that selectively target PI3K or PI3K and mammalian target of rapamycin
Externí odkaz:
https://doaj.org/article/d0983e4f9813439184cf3adfb4b7c460
Autor:
Madeleine Cule, Nick van Bruggen, Eugene Melamud, Garret A. FitzGerald, D. Leland Taylor, Danish Saleheen, Anastasia Baryshnikova, Anurag Sethi
Publikováno v:
J Clin Invest
Technological advances in rapid data acquisition have transformed medical biology into a data mining field, where new data sets are routinely dissected and analyzed by statistical models of ever-increasing complexity. Many hypotheses can be generated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::593e08f500447c03820f6231974b36ab
https://doi.org/10.1172/jci129196
https://doi.org/10.1172/jci129196
Autor:
Haopeng Xiao, Luiz H.M. Bozi, Yizhi Sun, Christopher L. Riley, Vivek M. Philip, Mandy Chen, Jiaming Li, Tian Zhang, Evanna L. Mills, Margo P. Emont, Wenfei Sun, Anita Reddy, Ryan Garrity, Jiani Long, Tobias Becher, Laura Potano Vitas, Dina Laznik-Bogoslavski, Martha Ordonez, Xinyue Liu, Xiong Chen, Yun Wang, Weihai Liu, Nhien Tran, Yitong Liu, Yang Zhang, Aaron M. Cypess, Andrew P. White, Yuchen He, Rebecca Deng, Heiko Schöder, Joao A. Paulo, Mark P. Jedrychowski, Alexander S. Banks, Yu-Hua Tseng, Paul Cohen, Linus T. Tsai, Evan D. Rosen, Samuel Klein, Maria Chondronikola, Fiona E. McAllister, Nick Van Bruggen, Edward L. Huttlin, Bruce M. Spiegelman, Gary A. Churchill, Steven P. Gygi, Edward T. Chouchani
Publikováno v:
Cell. 185:4654-4673.e28
Brown adipose tissue (BAT) regulates metabolic physiology. However, nearly all mechanistic studies of BAT protein function occur in a single inbred mouse strain, which has limited the understanding of generalizable mechanisms of BAT regulation over p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::748551ec42a3be7a69d4b8e61052022c
https://doi.org/10.1016/j.cell.2022.10.003
https://doi.org/10.1016/j.cell.2022.10.003
Autor:
Elena P. Sorokin, Madeleine Cule, Nicolas Basty, Brandon Whitcher, Jimmy D. Bell, Nick van Bruggen, Yi Liu, E. Louise Thomas
Publikováno v:
eLife
eLife, Vol 10 (2021)
eLife, Vol 10 (2021)
Cardiometabolic diseases are an increasing global health burden. While socioeconomic, environmental, behavioural, and genetic risk factors have been identified, a better understanding of the underlying mechanisms is required to develop more effective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::669bcfa763f16d722440248771c9950b
https://pubmed.ncbi.nlm.nih.gov/34128465
https://pubmed.ncbi.nlm.nih.gov/34128465
Autor:
Jimmy D. Bell, Nicolas Basty, Nick van Bruggen, Madeleine Cule, E. Louise Thomas, Yi Liu, Elena P. Sorokin, Brandon Whitcher
Cardiometabolic diseases are an increasing global health burden. While well established socioeconomic, environmental, behavioural, and genetic risk factors have been identified, our understanding of the drivers and mechanisms underlying these complex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5cda386c13f164cb973454c63b86544a
https://doi.org/10.1101/2020.07.14.187070
https://doi.org/10.1101/2020.07.14.187070
Autor:
Garret A. FitzGerald, Rory Collins, Daniel J. Rader, David Botstein, Nick van Bruggen, Keith Peters, Robert M. Califf
Publikováno v:
Science (New York, N.Y.). 361(6402)
A “human phenomic science” approach could accelerate personalized medicine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::847846fbb46be75e1a1bbbb7f9518c82
https://pubmed.ncbi.nlm.nih.gov/30093589
https://pubmed.ncbi.nlm.nih.gov/30093589
Autor:
Sharon E. Ungersma, Jean Michel Vernes, Lori Friedman, Liliane Robillard, Tim C. Cao, Hartmut Koeppen, Shelby K. Wyatt, Deepak Sampath, Jed Ross, Yu-Ju Gloria Meng, Napoleone Ferrara, Calvin Ho, Maresa Caunt, Richard A.D. Carano, Weilan Ye, Nick van Bruggen, Jeffrey Eastham-Anderson, Kai H. Barck, Philip Vitorino, Ulka Vijapurkar, Jason Oeh, Guanglei Zhuang, Hani Bou Reslan
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 15, Iss 7, Pp 694-711 (2013)
The phosphatidylinositol 3-kinase (PI3K) pathway is a central mediator of vascular endothelial growth factor (VEGF)-driven angiogenesis. The discovery of small molecule inhibitors that selectively target PI3K or PI3K and mammalian target of rapamycin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::012b9e017e13a17f2f1fc1f6dcf0f9bd
http://www.sciencedirect.com/science/article/pii/S1476558613800644
http://www.sciencedirect.com/science/article/pii/S1476558613800644