Zobrazeno 1 - 10
of 118
pro vyhledávání: '"Nick Plant"'
Design principles of nuclear receptor signaling: how complex networking improves signal transduction
Autor:
Alexey N Kolodkin, Frank J Bruggeman, Nick Plant, Martijn J Moné, Barbara M Bakker, Moray J Campbell, Johannes P T M van Leeuwen, Carsten Carlberg, Jacky L Snoep, Hans V Westerhoff
Publikováno v:
Molecular Systems Biology, Vol 6, Iss 1, Pp 1-14 (2010)
Abstract The topology of nuclear receptor (NR) signaling is captured in a systems biological graphical notation. This enables us to identify a number of ‘design’ aspects of the topology of these networks that might appear unnecessarily complex or
Externí odkaz:
https://doaj.org/article/f2b210373e1d4c64b882cf37bd83e411
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e33253 (2012)
Fluorescent tracer dyes represent an important class of sub-cellular probes and allow the examination of cellular processes in real-time with minimal impact upon these processes. Such tracer dyes are becoming increasingly used for the examination of
Externí odkaz:
https://doaj.org/article/8f2473dbd3e04fbb97e0701915c9ad5b
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e16703 (2011)
The nuclear receptor superfamily of ligand-activated transcription factors plays a central role in the regulation of cellular responses to chemical challenge. Nuclear receptors are activated by a wide range of both endogenous and exogenous chemicals,
Externí odkaz:
https://doaj.org/article/f0cc0609c90b4db89b407e63d417f61a
Autor:
Nick Plant
Molecular Toxicology is a concise introduction to the subject, taking the reader through the theoretical principles of toxicology followed by specific examples. In the first section, the concepts behind possible mechanisms of toxicity are described (
Publikováno v:
BMC Systems Biology, Vol 11, Iss 1, Pp 1-16 (2017)
BMC Systems Biology
BMC Systems Biology
Background Estrogen is a vital hormone that regulates many biological functions within the body. These include roles in the development of the secondary sexual organs in both sexes, plus uterine angiogenesis and proliferation during the menstrual cyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0af48023cea325f385897eaa9c0e96cd
http://link.springer.com/article/10.1186/s12918-017-0520-3
http://link.springer.com/article/10.1186/s12918-017-0520-3
Autor:
Elaina M. Maldonado, Vytautas Leoncikas, Ciarán Fisher, Nick Plant, Andrzej M. Kierzek, J. Bernadette Moore
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology. 6:732-746
The scope of physiologically based pharmacokinetic (PBPK) modeling can be expanded by assimilation of the mechanistic models of intracellular processes from systems biology field. The genome scale metabolic networks (GSMNs) represent a whole set of m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64183cd6f2477328384dc70cddf40e76
https://doi.org/10.1002/psp4.12230
https://doi.org/10.1002/psp4.12230
Publikováno v:
Environmental Toxicology. 32:764-775
The current studies investigate whether synergistic or antagonistic interactions in the upregulation of CYP1 activity occur in binary mixtures of polycyclic aromatic hydrocarbons (PAHs) involving benzo[a]pyrene and five other structurally diverse PAH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3d012b1b9463aebe935a703d966d4c8
https://doi.org/10.1002/tox.22276
https://doi.org/10.1002/tox.22276
Autor:
Nick Plant
Publikováno v:
Toxicology Research. 4:9-22
The science of toxicology is the science of the system. Toxicologists aim to understand and predict the adverse effects of chemicals on biological systems. As biological systems are extremely complex, the challenge of predicting human toxicity early
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41ae2cb3ac9130cfbfb382b94354b95d
https://doi.org/10.1039/c4tx00058g
https://doi.org/10.1039/c4tx00058g
Autor:
Dawn J. Mazzatti, Elaina M. Maldonado, Ciarán Fisher, J. Bernadette Moore, Marcus J. Tindall, Amy L. Barber, Andrzej M. Kierzek, Nick Plant
Publikováno v:
NPJ Systems Biology and Applications
npj Systems Biology and Applications, Vol 4, Iss 1, Pp 1-10 (2018)
npj Systems Biology and Applications, Vol 4, Iss 1, Pp 1-10 (2018)
Non-alcoholic fatty liver disease (NAFLD) is a serious public health issue associated with high fat, high sugar diets. However, the molecular mechanisms mediating NAFLD pathogenesis are only partially understood. Here we adopt an iterative multi-scal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0969c3d1bd7f6e54dbd6636d79c1132
https://pubmed.ncbi.nlm.nih.gov/30131870
https://pubmed.ncbi.nlm.nih.gov/30131870