Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Nick N. Gorgani"'
Publikováno v:
Biomolecules, Vol 13, Iss 9, p 1307 (2023)
Hypoglycemic medications that could be co-administered with prebiotics and functional foods can potentially reduce the burden of metabolic diseases such as Type 2 Diabetes Mellitus (T2DM). The efficacy of drugs such as metformin and sulfonylureas can
Externí odkaz:
https://doaj.org/article/cb7b7800caf54d49b1a458747d09715b
Autor:
Usma Munawara, Khalida Perveen, Annabelle G. Small, Trishni Putty, Alex Quach, Nick N. Gorgani, Charles S. Hii, Catherine A. Abbott, Antonio Ferrante
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
The B7 family-related protein V-set and Ig containing 4 (VSIG4), also known as Z39Ig and Complement Immunoglobulin Receptor (CRIg), is the most recent of the complement receptors to be identified, with substantially distinct properties from the class
Externí odkaz:
https://doaj.org/article/3e4498936672480f91ae340f0fd0d6a2
Autor:
Usma Munawara, Annabelle G. Small, Alex Quach, Nick N. Gorgani, Catherine A. Abbott, Antonio Ferrante
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
Abstract Complement Receptor Immunoglobulin (CRIg), selectively expressed by macrophages, plays an important role in innate immunity by promoting phagocytosis of bacteria. Thus modulation of CRIg on macrophages by cytokines can be an important mechan
Externí odkaz:
https://doaj.org/article/1ca7071f6f054365995a4a74100e0320
Autor:
Luke R Odell, Nigel C. Jones, Ngoc Chau, Mark J. Robertson, Joseph I Ambrus, Fiona M Deane, Kelly A. Young, Ainslie Whiting, Jing Xue, Kate Prichard, James A. Daniel, Nick N. Gorgani, Terence J O'brien, Phillip J Robinson, Adam McCluskey
Publikováno v:
RSC Medicinal Chemistry.
We show that dansylcadaverine (1) a known in-cell inhibitor of clathrin mediated endocytosis (CME), moderately inhibits dynamin I (dynI) GTPase activity (IC50 45 μM) and transferrin (Tfn) endocytosis in U2OS...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b1cdf45c9370444e924500dfa5f6b2a
https://doi.org/10.1039/d2md00371f
https://doi.org/10.1039/d2md00371f
Autor:
Nick N Gorgani
Publikováno v:
Research Review.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3c72e6d4350eadd32b4ddb2ea9f75c6
https://doi.org/10.52845/cmro/2022/5-6-2
https://doi.org/10.52845/cmro/2022/5-6-2
Autor:
Annabelle G. Small, Charles S. T. Hii, Trishni Putty, Antonio Ferrante, Alex Quach, Catherine A. Abbott, Khalida Perveen, Usma Munawara, Nick N. Gorgani
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 10 (2019)
Frontiers in Immunology, Vol 10 (2019)
The B7 family-related protein V-set and Ig containing 4 (VSIG4), also known as Z39Ig and Complement Immunoglobulin Receptor (CRIg), is the most recent of the complement receptors to be identified, with substantially distinct properties from the class
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac0385d6b20265e4b3e8b4499fcf5ca8
http://europepmc.org/articles/PMC6914870
http://europepmc.org/articles/PMC6914870
Autor:
Anna Mariana, Jennette A. Sakoff, Kelly A. Young, Luke R. Odell, Jayne Gilbert, Timothy A. Hill, Damien J. Keating, Aimee E. Novelle, Nick N. Gorgani, Phillip J. Robinson, Ngoc Chau, Megan Chircop, Ellen M. van Dam, James A. Daniel, Fiona M. Deane, Michael A. Cousin, Ainslie Whiting, Adam McCluskey, Annie Quan, Swetha Perera, Andrew B. McGeachie
Publikováno v:
ACS Chemical Biology. 8:1507-1518
Dynamin is required for clathrin-mediated endocytosis (CME). Its GTPase activity is stimulated by phospholipid binding to its PH domain, which induces helical oligomerization. We have designed a series of novel pyrimidine-based "Pyrimidyn" compounds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e91e1ed80da1877f3552c09606e540c
https://doi.org/10.1021/cb400137p
https://doi.org/10.1021/cb400137p
Autor:
Annabelle G. Small, Antonio Ferrante, Catherine A. Abbott, Usma Munawara, Alex Quach, Nick N. Gorgani
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ccd84ca35674745ef37e67b6b254767
https://pubmed.ncbi.nlm.nih.gov/28642550
https://pubmed.ncbi.nlm.nih.gov/28642550
Autor:
Charles S. T. Hii, Antonio Ferrante, Violet Mukaro, Nick N. Gorgani, Ornnuthchar Poungpair, Amanda Tirimacco, Umaporn Thathaisong
Publikováno v:
The American Journal of Pathology. 179:1310-1318
Although the importance of the macrophage complement receptor immunoglobulin (CRIg) in the phagocytosis of complement opsonized bacteria and in inflammation has been established, the regulation of CRIg expression remains undefined. Because cellular a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeb8f8022da7c3e7b04f656c6ac37bf7
https://doi.org/10.1016/j.ajpath.2011.05.021
https://doi.org/10.1016/j.ajpath.2011.05.021
The Pthaladyns: GTP Competitive Inhibitors of Dynamin I and II GTPase Derived from Virtual Screening
Autor:
Mark J. Robertson, Ainslie Whiting, Anna Mariana, Adam McCluskey, Nick N. Gorgani, Ruben Abagyan, Christopher P. Gordon, Dian Herlinda Octorina Howan, Luke R. Odell, Ngoc Chau, Phillip J. Robinson, James A. Daniel
Publikováno v:
Journal of Medicinal Chemistry. 53:5267-5280
We report the development of a homology model for the GTP binding domain of human dynamin I based on the corresponding crystal structure of Dictyostelium discoidum dynamin A. Virtual screening identified 2-[(2-biphenyl-2-yl-1,3-dioxo-2,3-dihydro-1H-i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::219894436cebc8aef0fd86ae2dc7f40d
https://doi.org/10.1021/jm100442u
https://doi.org/10.1021/jm100442u