Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Nick Mulholland"'
Autor:
Chantal Belie, Andrew Plant, Nick Mulholland, Matthew McLachlan, Derek McCormack, Adrian Longstaff, Tony Kozakiewicz, Andy Knee, Katharine Ingram, Myriem El Qacemi, Martin Diggelmann, Jonathan Dallimore, Anne Dalençon, Eric Clarke, Jutta Boehmer, John Williams
Publikováno v:
CHIMIA, Vol 68, Iss 6 (2014)
An efficient synthesis of a difluorosulfone-containing herbicide has been achieved by selective reductive silylation of a symmetrical bis(trifluoromethyl)-1,2,3-triazole. Subsequently, a fluoride-induced reaction led to a difluoromethyl anion equival
Externí odkaz:
https://doaj.org/article/659ec8ca44444ecaace882876b1fa94d
Autor:
Nick Mulholland, Yu-Cheng Gu, Ming-Zhi Zhang, David Beattie, Sarah Turner, John Martin Clough, Chen-Yang Jia, Weihua Zhang, Guang-Fu Yang
Publikováno v:
European Journal of Medicinal Chemistry. 126:669-674
Based on examples of the successful applications in drug discovery of bioisosterism, a series of streptochlorin analogues in which indole has been replaced by other heterocycles has been designed and synthesized, as a continuation of our studies aime
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47c23a859d3167ced8c2a8b0c537b8bb
https://doi.org/10.1016/j.ejmech.2016.12.001
https://doi.org/10.1016/j.ejmech.2016.12.001
Autor:
Run-Ling Qiu, Haifeng Zhang, Shu-Ke Guo, Dai-Chuan Huang, Abdallah S. Ali, Xinya Han, Jun-Yang Tan, Da-Le Guo, Ya Gao, Qinfei Xia, Chang Liu, Zi-Long Song, Yu-Cheng Gu, Ming-Zhi Zhang, Nick Mulholland, Jing-Rui Liu, Yun Deng, Bing Jin
Publikováno v:
Bioorganic & Medicinal Chemistry. 35:116073
Streptochlorin is a small molecule of indole alkaloid isolated from marine Streptomyces sp., it is a promising lead compound due to its potent bioactivity in preventing many phytopathogens in our previous study, but further structural modifications a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a34c332bbc0498fb2016ed4062dfd848
https://doi.org/10.1016/j.bmc.2021.116073
https://doi.org/10.1016/j.bmc.2021.116073
Autor:
Weihua Zhang, Nicholas Smith, Nick Mulholland, Gemma Hough, Hong-Qiang Dong, Yu-Cheng Gu, Anne Seville, Ming-Zhi Zhang
Publikováno v:
Tetrahedron. 79:131835
Pimprinine and streptochlorin are indole natural products produced by many species of organisms, and they are reported to possess a wide range of biological activities, such as anticancer, antiviral, antifungal activity and so on. In this study, thre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d2a7f17e3ac627db0a85a0e54244b95
https://doi.org/10.1016/j.tet.2020.131835
https://doi.org/10.1016/j.tet.2020.131835
Autor:
Guang-Fu Yang, Yu-Cheng Gu, Qiong Chen, Dianne Irwin, John Martin Clough, Sarah Turner, Nick Mulholland, Ming-Zhi Zhang, Cai-Hong Xie
Publikováno v:
European Journal of Medicinal Chemistry. 92:776-783
Streptochlorin, first isolated as a new antibiotic in 1988 from the lipophilic extracts of the mycelium of a Streptomyces sp, is an indole natural products with a variety of biological activities. Based on the methods developed for the synthesis of p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec2b3c476216a4776a9cff393315957d
https://doi.org/10.1016/j.ejmech.2015.01.043
https://doi.org/10.1016/j.ejmech.2015.01.043
Autor:
Yu-Cheng Gu, David Beattie, Nick Mulholland, Ming-Zhi Zhang, Qiong Chen, John Martin Clough, Guang-Fu Yang, Dianne Irwin
Publikováno v:
European Journal of Medicinal Chemistry. 63:22-32
On the basis of the principle of combination of active structural moieties, a modified and efficient synthetic method for three series of novel indole-based 1,3,4-oxadiazoles is described. Bioassays conducted at Syngenta showed that several of the sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b1851ff0df0bc3e85c86dcd4887258d
https://doi.org/10.1016/j.ejmech.2013.01.038
https://doi.org/10.1016/j.ejmech.2013.01.038
Autor:
Nick Mulholland, John Martin Clough, David Beattie, Guang-Fu Yang, Yu-Cheng Gu, Shao-Wei Huang, Qiong-You Wu, Long Lin, Dianne Irwin
Publikováno v:
Chemical Biology & Drug Design. 80:682-692
Sclerotiorin, a chlorine-containing azaphilone-type natural product, was first isolated from Penicillium sclerotiorum and has been reported to exhibit weak fungicidal activity. Optimization of the substituents at the 3- and 5-positions of the sclerot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7fd13d5d1c6260343e9bc68b756d105
https://doi.org/10.1111/cbdd.12005
https://doi.org/10.1111/cbdd.12005
Autor:
Yu-Cheng Gu, Long Lin, Nick Mulholland, David Beattie, Shao-Wei Huang, John Martin Clough, Dianne Irwin, Guang-Fu Yang, Qiong-You Wu
Publikováno v:
Journal of Agricultural and Food Chemistry. 60:4480-4491
Sclerotiorin 1, first isolated from Penicillium sclerotiorum, has weak antifungal activity and belongs to the azaphilone-type family of natural products. Several series of sclerotiorin analogues were designed and synthesized with the aim of discoveri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0584326c25ba1d3954c6e52bb5f2ae0
https://doi.org/10.1021/jf300610j
https://doi.org/10.1021/jf300610j
Autor:
Derek Mccormack, Matthew M. W. McLachlan, Andrew Plant, Chantal Belie, Tony Kozakiewicz, Nick Mulholland, Andy Knee, Adrian Longstaff, Eric Daniel Clarke, John Williams, Myriem El Qacemi, Anne Jacqueline Dalencon, Jutta Elisabeth Boehmer, Martin Diggelmann, Jonathan Dallimore, Katharine Mary Ingram
Publikováno v:
CHIMIA, Vol 68, Iss 6 (2014)
An efficient synthesis of a difluorosulfone-containing herbicide has been achieved by selective reductive silylation of a symmetrical bis(trifluoromethyl)-1,2,3-triazole. Subsequently, a fluoride-induced reaction led to a difluoromethyl anion equival
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11a1f787d46c84ca18c49537aa09437b
https://pubmed.ncbi.nlm.nih.gov/25198756
https://pubmed.ncbi.nlm.nih.gov/25198756
Autor:
Yu-Cheng Gu, John Martin Clough, Dianne Irwin, Qiong Chen, Nick Mulholland, Guang-Fu Yang, Ming-Zhi Zhang, David Beattie
Publikováno v:
ChemInform. 44
On the basis of the principle of combination of active structural moieties, a modified and efficient synthetic method for three series of novel indole-based 1,3,4-oxadiazoles is described. Bioassays conducted at Syngenta showed that several of the sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c618cb80ceb25cd30b48c44e84fa190
https://doi.org/10.1002/chin.201341151
https://doi.org/10.1002/chin.201341151