Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Nick Menhart"'
Autor:
Xin Niu, Nick Menhart
Publikováno v:
Biochemistry. 60(10)
Exon skipping is a disease-modifying therapy in which oligonucleotide analogues mask specific exons, eliminating them from the mature mRNA, and also the cognate protein. That is one possible therapeutic aim, but it can also be used to restore the rea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e53f938cebd1cc34b459a1c67c8eaa85
https://pubmed.ncbi.nlm.nih.gov/33656846
https://pubmed.ncbi.nlm.nih.gov/33656846
Autor:
Xin Niu, Nick Menhart
Exon skipping is a disease modifying therapy that operates at the RNA level. In this strategy, oligonucleotide analog drugs are used to specifically mask specific exons and prevent them from inclusion in the mature mRNA. Of course, this also results
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::020daf028c616ee3db3ad9c394088f91
https://doi.org/10.1101/2020.10.10.334763
https://doi.org/10.1101/2020.10.10.334763
Duchenne muscular dystrophy is a common and devastating genetic disease that is primarily caused by exon deletions that create a genetic frameshift in dystrophin. Exon skipping therapy seeks to correct this by masking an exon during the mRNA maturati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9496bc2c27b54bd92a2cedd06476474e
Publikováno v:
Biophysical Journal. 114:340a-341a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d9af19ee6dae4b8a7bcf7e094fd3c57
https://doi.org/10.1016/j.bpj.2017.11.1901
https://doi.org/10.1016/j.bpj.2017.11.1901
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1804:1796-1809
We have conducted a biophysical scan of the rod region of dystrophin, targeting all 24 single spectrin type repeat, STR, motifs and 23 2-STR tandem motifs. Of these 47 targets, we were able to express and purify 39 and have characterized them with re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4492821d4834bec07357b2b3f10d4f0
https://doi.org/10.1016/j.bbapap.2010.03.009
https://doi.org/10.1016/j.bbapap.2010.03.009
Publikováno v:
Journal of Agricultural and Food Chemistry. 57:4698-4705
Information relating to the resistance of food allergens to thermal and/or chemical denaturation is critical if a reduction in protein allergenicity is to be achieved through food-processing means. This study examined the changes in the secondary str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9c7e90a414c7b3ffd6974d27e097dfb
https://doi.org/10.1021/jf803977z
https://doi.org/10.1021/jf803977z
Autor:
Nick Menhart, Olivier Delalande, Elisabeth Le Rumeur, Jean-François Hubert, Khushdeep Mangat, Anne-Elisabeth Molza
Publikováno v:
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2015, 290 (49), pp.29531-29541. ⟨10.1074/jbc.M115.680660⟩
Journal of Biological Chemistry, 2015, 290 (49), pp.29531-29541. ⟨10.1074/jbc.M115.680660⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2015, 290 (49), pp.29531-29541. ⟨10.1074/jbc.M115.680660⟩
Journal of Biological Chemistry, 2015, 290 (49), pp.29531-29541. ⟨10.1074/jbc.M115.680660⟩
International audience; Duchenne muscular dystrophy is a lethal genetic defect that is associated with the absence of dystrophin protein. Lack of dystrophin protein completely abolishes muscular nitric oxide synthase (NOS) function as a regulator of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c37a519b8dcfe4c085a468b232f8bc64
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01214011
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01214011
Autor:
Nick Menhart
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1764:993-999
Dystrophin is the protein whose defect underlies Duchenne Muscular Dystrophy, DMD, a common (1:3500 male births) and fatal condition in which muscle tissue deteriorates leading to death in the second or third decade of life. Dystrophin is coded for b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db0454bbe80418b49b363b2139beeba9
https://doi.org/10.1016/j.bbapap.2006.03.017
https://doi.org/10.1016/j.bbapap.2006.03.017
Publikováno v:
Journal of Synchrotron Radiation. 11:314-318
Small-angle X-ray scattering and size-exclusion chromatography have been combined within a unified experimental set-up to obtain molecular size information. Besides providing simultaneous corroborative data bearing on the same question from two disti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11537f600146ee8725be438daac016f5
https://doi.org/10.1107/s0909049504014086
https://doi.org/10.1107/s0909049504014086
Autor:
Paula Friedman, Mark A. Hayden, J. J. Russell, Lisa Roberts, Nick Menhart, Tracey L. Colpitts, Edward N. Granados, Patricia A. Billing-Medel, Steve Hodges, Stephen D. Stroupe
Publikováno v:
Biochemistry. 40:11048-11059
The mammaglobin gene has been shown to be preferentially expressed in breast tissue. Few genes match its specificity. Mammaglobin has generated much interest, and studies are ongoing to develop diagnostic tests for breast cancer based on the detectio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a9bbcd64b8eaf9bcc3cd9147be39dc2
https://doi.org/10.1021/bi010284f
https://doi.org/10.1021/bi010284f