Zobrazeno 1 - 10
of 166
pro vyhledávání: '"Nick J. Proudfoot"'
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
H2A.X histone variant gene encodes poly(A)+ and poly(A)- mRNA isoforms which are differentially expressed depending on cell lines. Here the authors show that upon DNA damage, cells expressing more poly(A)+ isoform require this isoform for de novo H2A
Externí odkaz:
https://doaj.org/article/90bcdc21996641338179013236fc44d3
Autor:
Ilaria Pettinati, Pawel Grzechnik, Claudia Ribeiro de Almeida, Jurgen Brem, Michael A McDonough, Somdutta Dhir, Nick J Proudfoot, Christopher J Schofield
Publikováno v:
eLife, Vol 7 (2018)
Replication-dependent (RD) core histone mRNA produced during S-phase is the only known metazoan protein-coding mRNA presenting a 3' stem-loop instead of the otherwise universal polyA tail. A metallo β-lactamase (MBL) fold enzyme, cleavage and polyad
Externí odkaz:
https://doaj.org/article/c86cc60afd9b46b4bbc5e0c815e0d772
Autor:
Nick J. Proudfoot
Publikováno v:
Genes & Development. 37:43-44
Autor:
Takayuki, Nojima, Nick J, Proudfoot
Publikováno v:
Nature reviews. Molecular cell biology. 23(6)
Mammalian genomes express two principal gene categories through RNA polymerase II-mediated transcription: protein-coding transcription units and non-coding RNA transcription units. Non-coding RNAs are further divided into relatively abundant structur
Autor:
Luciano E. Marasco, Gwendal Dujardin, Rui Sousa-Luís, Ying Hsiu Liu, Jose N. Stigliano, Tomoki Nomakuchi, Nick J. Proudfoot, Adrian R. Krainer, Alberto R. Kornblihtt
Publikováno v:
Cell. 185:2057-2070.e15
Spinal muscular atrophy (SMA) is a motor-neuron disease caused by mutations of the SMN1 gene. The human paralog SMN2, whose exon 7 (E7) is predominantly skipped, cannot compensate for the lack of SMN1. Nusinersen is an antisense oligonucleotide (ASO)
Autor:
Adrian R. Krainer, Gwendal Dujardin, Rui Sousa-Luís, Tomoki Nomakuchi, José Stigliano, Alberto R. Kornblihtt, Nick J. Proudfoot, Luciano Marasco, Ying Hsiu Liu
Publikováno v:
SSRN Electronic Journal.
Spinal Muscular Atrophy (SMA) is a motor-neuron disease caused by mutations of the SMN1 gene. The human paralog SMN2, whose exon 7 (E7) is predominantly skipped cannot compensate for the lack of SMN1. Nusinersen is an antisense oligonucleotide that u
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Phosphorylated H2A.X is a critical chromatin marker of DNA damage repair (DDR) in higher eukaryotes. However, H2A.X gene expression remains relatively uncharacterised. Replication-dependent (RD) histone genes generate poly(A)- mRNA encoding new histo
Autor:
Rui Sousa-Luís, Inna Zukher, Hiroshi Kimura, Nick J. Proudfoot, Gwendal Dujardin, Maria Carmo-Fonseca, Takayuki Nojima
SUMMARYMammalian chromatin is the site of both RNA polymerase II (Pol II) transcription and coupled RNA processing. However, molecular details of such co-transcriptional mechanisms remain obscure, partly due to technical limitations in purifying auth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ff98a0f06f6932136d7ff045d7a46e6
https://doi.org/10.1101/2020.11.09.374108
https://doi.org/10.1101/2020.11.09.374108
Autor:
Sue Mei Tan-Wong, Nick J Proudfoot
Publikováno v:
eLife, Vol 2 (2013)
A protein long recognized for its role in DNA repair has now paradoxically been implicated in DNA damage.
Externí odkaz:
https://doaj.org/article/2e0777a06a5b49d0ab57a59f821b7e0d