Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Nick J Gay"'
Autor:
Daffolyn Rachael Fels Elliott, Juliane Perner, Xiaodun Li, Martyn F Symmons, Brett Verstak, Matthew Eldridge, Lawrence Bower, Maria O'Donovan, Nick J Gay, OCCAMS Consortium, Rebecca C Fitzgerald
Publikováno v:
PLoS Genetics, Vol 13, Iss 5, p e1006808 (2017)
Esophageal adenocarcinoma (EAC) develops in an inflammatory microenvironment with reduced microbial diversity, but mechanisms for these influences remain poorly characterized. We hypothesized that mutations targeting the Toll-like receptor (TLR) path
Externí odkaz:
https://doaj.org/article/795eeb65e0a5409c98148b4a71db3485
Autor:
Georgina L Hold, Susan Berry, Karin A Saunders, Janice Drew, Claus Mayer, Heather Brookes, Nick J Gay, Emad M El-Omar, Clare E Bryant
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e111460 (2014)
Dysregulated Toll-Like Receptor (TLR) signalling and genetic polymorphisms in these proteins are linked to many human diseases. We investigated TLR4 functional variants D299G and T399I to assess the impact on LPS-induced responsiveness in comparison
Externí odkaz:
https://doaj.org/article/00f6564b2db24b8cae4420cc91841f22
Autor:
Clare E. Bryant, Nick J. Gay, Stephane Heymans, Sandra Sacre, Liliana Schaefer, Kim S. Midwood
Publikováno v:
Critical Reviews in Biochemistry and Molecular Biology, 50(5), 359-379. Informa Healthcare
As we learn more about the biology of the Toll-like receptors (TLRs), a wide range of molecules that can activate this fascinating family of pattern recognition receptors emerges. In addition to conserved pathogenic components, endogenous danger sign
Publikováno v:
Protein Expression and Purification
Myeloid differentiation proteins MD-1 and MD-2 have both been shown to form a heterogeneous collection of oligomers when expressed in absence of their respective receptor, RP105 and TLR4. The biological relevance of these oligomers is not clear. Only
Autor:
Anne Marit de Groot, Kaushik Thanki, Monique Gangloff, Emily Falkenberg, Xianghui Zeng, Djai C.J. van Bijnen, Willem van Eden, Henrik Franzyk, Hanne M. Nielsen, Femke Broere, Nick J. Gay, Camilla Foged, Alice J.A.M. Sijts
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 11, Iss C, Pp 159-169 (2018)
Therapeutics based on small interfering RNA (siRNA) have promising potential as antiviral and anti-inflammatory agents. To deliver siRNA across cell membranes to reach the RNAi pathway in the cytosol of target cells, non-viral nanoparticulate deliver
Externí odkaz:
https://doaj.org/article/8b2e828dc91a4199a7135eccfe8c545c