Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Nick Holoweckyj"'
Autor:
Nick M. Durham, Nick Holoweckyj, Randall S. MacGill, Kelly McGlinchey, Ching Ching Leow, Scott H. Robbins
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 5, Iss 1, Pp 1-12 (2017)
Abstract Background The expansion of antigen-specific CD8 T cells is important in generating an effective and long-lasting immune response to tumors and viruses. Glucocorticoid-induced tumor necrosis factor receptor family-related receptor (GITR) is
Externí odkaz:
https://doaj.org/article/c0411b30dc4c45a186da0ada7b815816
Autor:
Emma V. Jones, Kevin Schifferli, James Harper, Katie Streicher, Nicola Rath, Nick Holoweckyj, Nicholas M. Durham, Susie Hayes, Noel R. Monks, Kelly McGlinchey, Elizabeth J. Kelly, Shannon Burke, Todd Creasy, Danielle Carroll, Ravinder Tammali
Publikováno v:
Cancer Research. 80:5544-5544
Oncolytic viruses (OV) are defined by their intrinsic or engineered tropism for tumor cells. Understanding the drivers of susceptibility to infection as well as the downstream intracellular signaling and immune activation profile is critical in ident
Autor:
Ching Ching Leow, Nick Holoweckyj, Randall S. MacGill, Nick Durham, Kelly McGlinchey, Scott H. Robbins
Publikováno v:
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 5, Iss 1, Pp 1-12 (2017)
Journal for ImmunoTherapy of Cancer, Vol 5, Iss 1, Pp 1-12 (2017)
Background The expansion of antigen-specific CD8 T cells is important in generating an effective and long-lasting immune response to tumors and viruses. Glucocorticoid-induced tumor necrosis factor receptor family-related receptor (GITR) is a co-stim
Autor:
Philip Brohawn, Zachary A. Cooper, Giovanni Melillo, Han Si, Yashaswi Shrestha, A. Franovic, Nick Holoweckyj, Katie Streicher, M. Jure-Kunkel, Young S. Lee, Rajiv Raja, Brandon W. Higgs, E. Helman, Koustubh Ranade, Jiabu Ye, Phillip A. Dennis, Shaad Essa Abdullah, Mike Kuziora, Ikbel Achour, Pralay Mukhopadhyay
Publikováno v:
Annals of Oncology. 29:x1
Autor:
Katie Streicher, Young S. Lee, Brandon W. Higgs, Li Cheng, Fernanda Pilataxi, Yinong Sebastian, Lydia Greenlees, Todd Creasy, Nick Holoweckyj, Michael Kuziora, Koustubh Ranade
Publikováno v:
Cancer Research. 78:5390-5390
Background: T cell exhaustion is driven by persistence of antigen and inflammation, common features of cancer. The success of a checkpoint inhibitor blockade may depend upon reactivation of pre-existing tumor-specific CD8+ T cells in the tumor microe
Autor:
Amanda Watkins, Ching Ching Leow, Michelle Morrow, Natalie J. Tigue, Emily Dick, Scott A. Hammond, Lesley Young, Lisa Bamber, Nick Holoweckyj, Robert W. Wilkinson, Rebecca Leyland, Ross Stewart, Kathy Mulgrew
Publikováno v:
Cancer Research. 76:4902-4902
GITR is a member of the TNFR superfamily of proteins and is expressed on resting regulatory T-cells and on other T-cells following activation. Signals through GITR have been shown to drive increased T-cell activity and reduced regulatory T-cell funct
Autor:
Qihui Huang, Stacy Fuhrmann, Jonathan Rios-Doria, Kelly McGlinchey, Robert E. Hollingsworth, Carl Hay, Edmund Poon, Nick Holoweckyj, Erin Sult, Ching Ching Leow, Ronald Herbst, Gundo Diedrich, Melissa Damschroder, Kris Sachsenmeier, Nicholas M. Durham, Kathy Mulgrew, Raymond Rothstein, Scott A. Hammond
Publikováno v:
Oncoimmunology
MEDI9447 is a human monoclonal antibody that is specific for the ectoenzyme CD73 and currently undergoing Phase I clinical trials. Here we show that MEDI9447 is a potent inhibitor of CD73 ectonucleotidase activity, with wide ranging immune regulatory
Autor:
Jo Soden, Carl Hay, Qihui Huang, Leo S. Price, Bram Herpers, Kuan Yan, Robert E. Hollingsworth, Ralph Minter, Sandrine Guillard, Nick Holoweckyj, Jim Freeth, Steven Rust, Kris Sachsenmeier, Alan Sandercock, Matt Flynn, Lutz Jermutus
Publikováno v:
Molecular Cancer
Background Monolayer cultures of immortalised cell lines are a popular screening tool for novel anti-cancer therapeutics, but these methods can be a poor surrogate for disease states, and there is a need for drug screening platforms which are more pr