Zobrazeno 1 - 10
of 226
pro vyhledávání: '"Nick H T, Ten Hacken"'
Autor:
Dennis Kruk, Anna C. Y. Yeung, Alen Faiz, Nick H. T. ten Hacken, Wim Timens, Toin H. van Kuppevelt, Willeke Daamen, Danique Hof, Martin C. Harmsen, Mauricio Rojas, Irene H. Heijink
Publikováno v:
Respiratory Research, Vol 24, Iss 1, Pp 1-12 (2023)
Abstract Background Chronic obstructive pulmonary disease (COPD) is characterized by irreversible lung tissue damage. Novel regenerative strategies are urgently awaited. Cultured mesenchymal stem/stromal cells (MSCs) have shown promising results in e
Externí odkaz:
https://doaj.org/article/8b2a51adaa564845abc7e12fc325f547
Autor:
Frank Klont, Peter Horvatovich, Russell P. Bowler, Eva van Rikxoort, Jean-Paul Charbonnier, Marcel Kwiatkowski, David A. Lynch, Stephen Humphries, Rainer Bischoff, Nick H. T. ten Hacken, Simon D. Pouwels
Publikováno v:
Respiratory Research, Vol 23, Iss 1, Pp 1-9 (2022)
Abstract Background There is a strong need for biomarkers to better characterize individuals with COPD and to take into account the heterogeneity of COPD. The blood protein sRAGE has been put forward as promising biomarker for COPD in general and emp
Externí odkaz:
https://doaj.org/article/6caddc2edcc14de0adb3b7b34b2ddd3b
Autor:
Katherine A. Pratte, Jeffrey L. Curtis, Katerina Kechris, David Couper, Michael H. Cho, Edwin K. Silverman, Dawn L. DeMeo, Frank C. Sciurba, Yingze Zhang, Victor E. Ortega, Wanda K. O’Neal, Lucas A. Gillenwater, David A. Lynch, Eric A. Hoffman, John D. Newell, Alejandro P. Comellas, Peter J. Castaldi, Bruce E. Miller, Simon D. Pouwels, Nick H. T. ten Hacken, Rainer Bischoff, Frank Klont, Prescott G. Woodruff, Robert Paine, R. Graham Barr, John Hoidal, Claire M. Doerschuk, Jean-Paul Charbonnier, Ruby Sung, Nicholas Locantore, John G. Yonchuk, Sean Jacobson, Ruth Tal-singer, Debbie Merrill, Russell P. Bowler
Publikováno v:
Respiratory Research, Vol 22, Iss 1, Pp 1-13 (2021)
Abstract Background Soluble receptor for advanced glycation end products (sRAGE) is a proposed emphysema and airflow obstruction biomarker; however, previous publications have shown inconsistent associations and only one study has investigate the ass
Externí odkaz:
https://doaj.org/article/4e44582e7f784171ad0cc7e5e1a33440
Autor:
Alen Faiz, Maarten van den Berge, Cornelis J. Vermeulen, Nick H. T. ten Hacken, Victor Guryev, Simon D. Pouwels
Publikováno v:
Respiratory Research, Vol 20, Iss 1, Pp 1-4 (2019)
Abstract Cigarette smoking is one of the major risk factors for the development of chronic obstructive pulmonary disease (COPD). Evidence is accumulating that Receptor for Advanced Glycation-End products (RAGE)-signaling is a key pathway in the patho
Externí odkaz:
https://doaj.org/article/f088ad59cc4b483abd6471b17f49b364
Autor:
Claire A. Cox, Ilse M. Boudewijn, Sebastiaan J. Vroegop, Siebrig Schokker, Anne J. Lexmond, Henderik W. Frijlink, Paul Hagedoorn, Judith M. Vonk, Martijn P. Farenhorst, Nick H. T. ten Hacken, Huib A. M. Kerstjens, Maarten van den Berge
Publikováno v:
BMC Pulmonary Medicine, Vol 19, Iss 1, Pp 1-9 (2019)
Abstract Background Bronchial provocation is often used to confirm asthma. Dyspnea sensation, however, associates poorly with the evoked drop in FEV1. Provocation tests only use the large airways parameter FEV1, although dyspnea is associated with bo
Externí odkaz:
https://doaj.org/article/90ac62831998481981990fd736253aed
Autor:
Dennis M. L. W. Kruk, Marissa Wisman, Jacobien A. Noordhoek, Mehmet Nizamoglu, Marnix R. Jonker, Harold G. de Bruin, Karla Arevalo Gomez, Nick H. T. ten Hacken, Simon D. Pouwels, Irene H. Heijink
Publikováno v:
Cells, Vol 10, Iss 11, p 2860 (2021)
COPD is characterized by irreversible lung tissue damage. We hypothesized that lung-derived mesenchymal stromal cells (LMSCs) reduce alveolar epithelial damage via paracrine processes, and may thus be suitable for cell-based strategies in COPD. We ai
Externí odkaz:
https://doaj.org/article/c260538f10634f8fb47eb09a8a7cee22
Autor:
Ilse M. Boudewijn, Alen Faiz, Katrina Steiling, Erica van der Wiel, Eef D. Telenga, Susan J. M. Hoonhorst, Nick H. T. ten Hacken, Corry-Anke Brandsma, Huib A. M. Kerstjens, Wim Timens, Irene H. Heijink, Marnix R. Jonker, Harold G. de Bruin, J. Sebastiaan Vroegop, Henk R. Pasma, Wim G. Boersma, Pascal Wielders, Frank van den Elshout, Khaled Mansour, Avrum Spira, Marc E. Lenburg, Victor Guryev, Dirkje S. Postma, Maarten van den Berge
Publikováno v:
Respiratory Research, Vol 18, Iss 1, Pp 1-10 (2017)
Abstract Background Nasal gene expression profiling is a promising method to characterize COPD non-invasively. We aimed to identify a nasal gene expression profile to distinguish COPD patients from healthy controls. We investigated whether this COPD-
Externí odkaz:
https://doaj.org/article/65ad28ccc1de4dada65462a59303ada5
Autor:
Benjamin A. Hoff, Esther Pompe, Stefanie Galbán, Dirkje S. Postma, Jan-Willem J. Lammers, Nick H. T. ten Hacken, Leo Koenderman, Timothy D. Johnson, Stijn E. Verleden, Pim A. de Jong, Firdaus A. A. Mohamed Hoesein, Maarten van den Berge, Brian D. Ross, Craig J. Galbán
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Parametric response mapping (PRM) of paired CT lung images has been shown to improve the phenotyping of COPD by allowing for the visualization and quantification of non-emphysematous air trapping component, referred to as functional small ai
Externí odkaz:
https://doaj.org/article/9785d98cf36c4301add005d9784b2033
Autor:
Peter J. Sterk, Michel van Weeghel, Tamara Dekker, Abilash Ravi, Annika W.M. Goorsenberg, Jouke T. Annema, Nick H. T. ten Hacken, Frédéric M. Vaz, Annemiek Dijkhuis, Yanaika S. Sabogal Piñeros, Pallav L. Shah, Barbara Dierdorp, René Lutter, Peter I. Bonta
Publikováno v:
Journal of Allergy and Clinical Immunology, 148(5), 1236-1248. MOSBY-ELSEVIER
Background: Asthma is a heterogeneous disease with differences in onset, severity, and inflammation. Bronchial epithelial cells (BECs) contribute to asthma pathophysiology.Objective: We determined whether transcriptomes of BECs reflect heterogeneity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6289ff2aa847a468b4cc50261a40ce2
https://doi.org/10.1016/j.jaci.2020.12.653
https://doi.org/10.1016/j.jaci.2020.12.653
Autor:
Erica van der Wiel, Anne J. Lexmond, Maarten van den Berge, Dirkje S. Postma, Paul Hagedoorn, Henderik W. Frijlink, Martijn P. Farenhorst, Anne H. de Boer, Nick H. T. ten Hacken
Publikováno v:
European Clinical Respiratory Journal, Vol 4, Iss 1 (2017)
Background: Small-particle inhaled corticosteroids (ICS) provide a higher small airway deposition than large-particle ICS. However, we are still not able to identify asthma patients who will profit most from small-particle treatment. Objective: We ai
Externí odkaz:
https://doaj.org/article/b37ab281581b4dbfa287a0844e2d58f7