Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Nick G Cunniffe"'
Autor:
Nick G Cunniffe, Alasdair J Coles, Benson S Chen, J William L Brown, Christopher E McMurran, Gioia Riboni-Verri, Gregory J Halliwell
Publikováno v:
BMJ Neurology Open, Vol 6, Iss 1 (2024)
One of the most promising approaches to delay, prevent or reverse disability progression in multiple sclerosis (MS) is to enhance endogenous remyelination and limit axonal degeneration. In clinical trials of remyelinating drugs, there is a need for r
Externí odkaz:
https://doaj.org/article/43db9b60a7164599a4790fe64b125845
Autor:
Darrel P Francis, Michael Brown, Nicholas J Matheson, Grant D Stewart, Jane Greenaway, Nick G Cunniffe, Simon J Gunter, Sarah W Burge, Tom Dymond, Hanif Esmail, Jacqui Galloway, Effrossyni Gkrania-Klotsas, George Katritsis, Martin D Knolle, Kelly Leonard, Zoe C McIntyre, Ben Prudon, Tommy Rampling, Mili Estee Torok, Ben Warne, Mark Yates, Sofia Villar
Publikováno v:
BMJ Open, Vol 10, Iss 10 (2020)
Objectives To analyse enrolment to interventional trials during the first wave of the COVID-19 pandemic in England and describe the barriers to successful recruitment in the circumstance of a further wave or future pandemics.Design We analysed regist
Externí odkaz:
https://doaj.org/article/9aa77797e2424303a05fbcb0e47a38f3
Autor:
Christopher E. McMurran, Trisha Mukherjee, J William L. Brown, Andrew W. Michell, Declan T. Chard, Robin J. M. Franklin, Alasdair J. Coles, Nick G. Cunniffe
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 9, Iss 7, Pp 1090-1094 (2022)
Abstract Remyelination efficiency declines with advancing age in animal models, but this has been harder to demonstrate in people with multiple sclerosis. We show that bexarotene, a putatively remyelinating retinoid‐X receptor agonist, shortened th
Externí odkaz:
https://doaj.org/article/6d0c103b90e94d1d9986fb871abf220e
Autor:
Charles ffrench-Constant, David G. MacManus, Jonathan Stutters, Owen R Pearson, DT Chard, Baris Kanber, Edward Needham, Zoya Georgieva, Joanne L. Jones, David Rog, Alasdair Coles, Rebecca S. Samson, Claudia A. M. Wheeler-Kingshott, J William L Brown, Ferran Prados, Peter Connick, Andrew W. Michell, Siddharthan Chandran, James Overell, Daniel R. Altmann, Paul D Flynn, Robin J.M. Franklin, Nick G Cunniffe, Carla Moran
Publikováno v:
Brown, J W L, Cunniffe, N G, Prados, F, Kanber, B, Jones, J L, Needham, E, Georgieva, Z, Rog, D, Pearson, O R, Overell, J, Macmanus, D, Samson, R S, Stutters, J, Ffrench-constant, C, Gandini Wheeler-kingshott, C A M, Moran, C, Flynn, P D, Michell, A W, Franklin, R J M, Chandran, S, Altmann, D R, Chard, D T, Connick, P & Coles, A J 2021, ' Safety and efficacy of bexarotene in patients with relapsing-remitting multiple sclerosis (CCMR One): a randomised, double-blind, placebo-controlled, parallel-group, phase 2a study ', The Lancet Neurology, vol. 20, no. 9, pp. 709-720 . https://doi.org/10.1016/S1474-4422(21)00179-4
Summary Background Progressive disability in multiple sclerosis occurs because CNS axons degenerate as a late consequence of demyelination. In animals, retinoic acid receptor RXR-gamma agonists promote remyelination. We aimed to assess the safety and
Autor:
J. William L. Brown, Ferran Prados, Daniel R. Altmann, Baris Kanber, Jonathan Stutters, Nick G. Cunniffe, Joanne L. Jones, Zoya G. Georgieva, Edward J. Needham, Cyrus Daruwalla, Claudia Gandini Wheeler‐Kingshott, Peter Connick, Siddharthan Chandran, Robin Franklin, David MacManus, Rebecca Samson, Alasdair Coles, Declan Chard
Publikováno v:
Brown, J W L, Prados, F, Altmann, D R, Kanber, B, Stutters, J, Cunniffe, N G, Jones, J L, Georgieva, Z G, Needham, E J, Daruwalla, C, Wheeler-kingshott, C G, Connick, P, Chandran, S, Franklin, R, Macmanus, D, Samson, R, Coles, A & Chard, D 2022, ' Remyelination varies between and within lesions in multiple sclerosis following bexarotene ', Annals of Clinical and Translational Neurology . https://doi.org/10.1002/acn3.51662
Funder: MS Society of the United Kingdom
Funder: NIHR UCLH Biomedical Research Centre
Funder: UCL
Funder: University College London
Funder: NIHR
Funder: Thorne Family Foundation
Funder: Adeslon Medical Research Foundatio
Funder: NIHR UCLH Biomedical Research Centre
Funder: UCL
Funder: University College London
Funder: NIHR
Funder: Thorne Family Foundation
Funder: Adeslon Medical Research Foundatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec7e55d07001e1784454cf8c5addcf27
Autor:
Alasdair Coles, Nick G Cunniffe
Publikováno v:
Journal of Neurology
The greatest unmet need in multiple sclerosis (MS) are treatments that delay, prevent or reverse progression. One of the most tractable strategies to achieve this is to therapeutically enhance endogenous remyelination; doing so restores nerve conduct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bcc60c5c8d890a30372d21edfc79684
Autor:
Li Su, Simon J Gunter, Effrossyni Gkrania-Klotsas, Kelly Leonard, Nicholas J Matheson, Darrel P. Francis, Mark Yates, Jane Greenaway, Anthony De Soyza, M. E. Török, Mark Toshner, Prapa Kanagaratnam, Ben Prudon, Ben Warne, George Katritsis, Grant D. Stewart, Michael Brown, Nick G Cunniffe, Zoe McIntyre, James Galloway, Sarah W. Burge, Tommy Rampling, Sofia S. Villar, Hanif Esmail, Clare Coyle, Jacqui Galloway, Tom Dymond, Martin D Knolle
Publikováno v:
BMJ Open
BMJ Open, Vol 10, Iss 10 (2020)
BMJ Open, Vol 10, Iss 10 (2020)
ObjectivesTo analyse enrolment to interventional trials during the first wave of the COVID-19 pandemic in England and describe the barriers to successful recruitment in the circumstance of a further wave or future pandemics.DesignWe analysed register
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f45007b4b18c700210a2aca2efe10ec0
https://www.repository.cam.ac.uk/handle/1810/311169
https://www.repository.cam.ac.uk/handle/1810/311169
Autor:
Alerie Guzman de la Fuente, Brooke Lumicisi, Sorrel R. B. Bickley, Judy Beveridge, Ranjit Kaur, Jennifer Robertson, Patrick Camilleri, Debbie Ainslie, Alasdair Coles, Stefano Pluchino, Anna Williams, Emma Gray, Gavin Giovannoni, Luca Peruzzotti-Jametti, Denise C. Fitzgerald, Kenneth Smith, Matthew Craner, David Baker, Alan Palmer, Alastair Wilkins, Nick G Cunniffe, Khue Anh Vuong, David Kozlowski, Don J. Mahad, Alan Rothaul, Lyndsey Shellard, Lorraine Hazlehurst, Raj Kapoor, Björn Neumann
Publikováno v:
Cunniffe, N, Vuong, K A, Ainslie, D, Baker, D, Beveridge, J, Bickley, S R B, Camilleri, P, Craner, M, Fitzgerald, D C, De La Fuente, A G, Giovannoni, G, Gray, E, Hazlehurst, L, Kapoor, R, Kaur, R, Kozlowski, D, Lumicisi, B, Mahad, D, Neumann, B, Palmer, A, Peruzzotti-Jametti, L, Pluchino, S, Robertson, J, Rothaul, A, Shellard, L, Smith, K J, Wilkins, A, Williams, A C & Coles, A J 2020, ' A systematic approach to selecting licensed drugs for repurposing in the treatment of progressive multiple sclerosis ', Journal of Neurology, Neurosurgery & Psychiatry . https://doi.org/10.1136/jnnp-2020-324286
ObjectiveTo establish a rigorous, expert-led, evidence-based approach to the evaluation of licensed drugs for repurposing and testing in clinical trials of people with progressive multiple sclerosis (MS).MethodsWe long-listed licensed drugs with evid