Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Nick Edmunds"'
Autor:
Adam Hargreaves, Rob Wallis, Derek J. Leishman, Louise Leong, Steven Engle, Lorna Ewart, David E. Watson, Kathleen M. Heinz-Taheny, Philip H. Milliken, Nick McMahon, Sarah Kirk, Peter Clements, Mike Aylott, Jean-Pierre Valentin, Magali Guffroy, Renaud Fleurance, Nick Edmunds
Publikováno v:
Toxicological Sciences. 176:224-235
Integrating nonclinical in vitro, in silico, and in vivo datasets holistically can improve hazard characterization and risk assessment. In pharmaceutical development, cardiovascular liabilities are a leading cause of compound attrition. Prior to clin
Autor:
Noel Dybdal, Jason Cordes, Nick Edmunds, Gemma Ward, Helen Prior, Aileen Milne, Brian M. Roche, Michael Gerhard Hoffmann, Pascal Champéroux, Stéphane Milano, Mike Engwall, Ken Meecham, Rick Nelson, Jean-Pierre Valentin, Eric Delpy, Anna Bottomley, Mike Foley, Robert Kaiser, Kathryn Chapman
Publikováno v:
Journal of Pharmacological and Toxicological Methods
Introduction The Safety Pharmacology Society (SPS) and National Centre for the Replacement, Refinement & Reduction of Animals in Research (NC3Rs) conducted a survey and workshop in 2015 to define current industry practices relating to housing of non-
Autor:
Amy Pointon, Nick Edmunds
Publikováno v:
Handbook of Biomarkers and Precision Medicine ISBN: 9780429202872
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d81234aef0805d77930fabfffbe90131
https://doi.org/10.1201/9780429202872-11
https://doi.org/10.1201/9780429202872-11
Autor:
Helen Prior, Marie C. South, Matthew Skinner, Richard Billing, Karen Oldman, Nick Edmunds, Ian Wallace, Jackie Moors, Aileen Milne
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 75:182
Introduction • Dogs are routinely housed individually during telemetry recording sessions. This is required when using the legacy DSI system, as animals need to be separated by at least 1 metre to avoid cross-talk between the signals transmitted on
Autor:
Kevin L. Dreher, Wendy G. Halpern, A. Eric Schultze, Peter Hoffmann, Nick Edmunds, Marty Sanders, Gerald Hirkaler, Dana Walker, James Greg Falls, Frank W. Sellke, Brian R. Berridge, Syril Pettit, Gary A. Gintant, James R. Turk
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 65(1)
Cardiovascular (CV) safety concerns are a significant source of drug development attrition in the pharmaceutical industry today. Though current nonclinical testing paradigms have largely prevented catastrophic CV events in Phase I studies, many chall
Autor:
Mark L. Lewis, Nick Edmunds, Stefan Sultana, Natalie M. Mount, Mark Ian Lansdell, Peter Wilson, Anne C. Heatherington, T. Bruce Brown, Alan Daniel Brown, Sarah Tweedy, David Hepworth, Julian Blagg, Cathryn Adams, Samantha Gaboardi, Kim Tang, Stevie Neal-Morgan, Andrew A. Calabrese, Neela Mistry, Maria Sudworth, David Sebastien Fradet, Neil Feeder, Val Gillon, Susan Cole, Steven W. Martin, Faye J. Quinton, Joanne Phipps, Scott Haughie, Denise J. Burring, Peter Stacey, Hugh Verrier, Chris Wayman
Publikováno v:
Journal of medicinal chemistry. 53(8)
The relevance of the melanocortin system to sexual activity is well established, and nonselective peptide agonists of the melanocortin receptors have shown evidence of efficacy in human sexual dysfunction. The role of the MC4 receptor subtype has rec
Autor:
Chantelle E. Connaughton, Nick Edmunds
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 64:e41
Autor:
Graeme T Clark, Sonia Roberts, Nick Edmunds, Jolie Harris, Jade Barker, Oladipupo Adeyemi, Mark Dewhurst
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 64:e51
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 62:e26
Autor:
Nick Edmunds, Mark Holbrook, Piet H. van der Graaf, Chantelle E. Connaughton, Mark Dewhurst, Neil Attkins, Neil Brunton
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 62:e30