Zobrazeno 1 - 10
of 156
pro vyhledávání: '"Nick E, Le Brun"'
Autor:
Paolo Olivieri, Moritz Klabes, Jason C. Crack, Angelika Lehmann, Sophie P. Bennett, Nick E. Le Brun, Silke Leimkühler
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 8 (2024)
ABSTRACT All sulfur transfer pathways generally have in common an l-cysteine desulfurase as the initial sulfur-mobilizing enzyme, which serves as a sulfur donor for the biosynthesis of numerous sulfur-containing biomolecules in the cell. In Escherich
Externí odkaz:
https://doaj.org/article/0f7a42399e5d4ba7bfb2e37cbde98729
Autor:
Roman Rohac, Jason C. Crack, Eve de Rosny, Océane Gigarel, Nick E. Le Brun, Juan C. Fontecilla-Camps, Anne Volbeda
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-11 (2022)
The crystal structure of the iron-sulfur protein NsrR from Streptomyces coelicolor bound to a gene operator fragment is reported and compared with other structures, giving insight into the structural determinants of DNA recognition by the NO sensor.
Externí odkaz:
https://doaj.org/article/b3514387f0f54ce683145e5562306895
Autor:
Chun‐Yang Li, Jason C. Crack, Simone Newton‐Payne, Andrew R. J. Murphy, Xiu‐Lan Chen, Benjamin J. Pinchbeck, Shun Zhou, Beth T. Williams, Ming Peng, Xiao‐Hua Zhang, Yin Chen, Nick E. Le Brun, Jonathan D. Todd, Yu‐Zhong Zhang
Publikováno v:
mLife, Vol 1, Iss 2, Pp 114-130 (2022)
Abstract Marine algae and bacteria produce approximately eight billion tonnes of the organosulfur molecule dimethylsulfoniopropionate (DMSP) in Earth's surface oceans annually. DMSP is an antistress compound and, once released into the environment, a
Externí odkaz:
https://doaj.org/article/c7a3ed76aef643449674ad7f2b0132df
Autor:
Ming Peng, Chun-Yang Li, Xiu-Lan Chen, Beth T. Williams, Kang Li, Ya-Nan Gao, Peng Wang, Ning Wang, Chao Gao, Shan Zhang, Marie C. Schoelmerich, Jillian F. Banfield, J. Benjamin Miller, Nick E. Le Brun, Jonathan D. Todd, Yu-Zhong Zhang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
S-methyl methionine (SMM) is a key molecule in production of dimethylsulfoniopropionate (DMSP), an important marine anti-stress compound, with roles in global nutrient cycling. Here, the authors determine the mechanism of SMM synthesis and uncover un
Externí odkaz:
https://doaj.org/article/10ba2b199f8b401dba6801e10d456021
Autor:
Jason C. Crack, Patricia Amara, Eve de Rosny, Claudine Darnault, Melanie R. Stapleton, Jeffrey Green, Anne Volbeda, Juan C. Fontecilla-Camps, Nick E. Le Brun
Publikováno v:
Inorganics, Vol 11, Iss 12, p 450 (2023)
The Escherichia coli fumarate and nitrate reduction (FNR) regulator acts as the cell’s master switch for the transition between anaerobic and aerobic respiration, controlling the expression of >300 genes in response to O2 availability. Oxygen is pe
Externí odkaz:
https://doaj.org/article/7626079ad8894802abd31312e1cfe935
Autor:
Yuxuan Ji, Li Wei, Anqi Da, Holger Stark, Peter-Leon Hagedoorn, Simone Ciofi-Baffoni, Sally A. Cowley, Ricardo O. Louro, Smilja Todorovic, Maria Andrea Mroginski, Yvain Nicolet, Maxie M. Roessler, Nick E. Le Brun, Mario Piccioli, William S. James, Wilfred R. Hagen, Kourosh H. Ebrahimi
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Externí odkaz:
https://doaj.org/article/14e01c9c674845c487345b274dc920b1
Publikováno v:
Chemical Science. 14:78-95
Iron-sulfur (Fe-S) clusters are cofactors essential for life. Though the proteins that function in the assembly of Fe-S clusters are well known, details of the molecular mechanism are less well established. The Isc (Iron-sulfur cluster) biogenesis ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12d4bf30d8fbbad9df4324cd41c66560
https://doi.org/10.1039/d2sc04169c
https://doi.org/10.1039/d2sc04169c
Autor:
Bassam K. Kudhair, Andrea M. Hounslow, Matthew D. Rolfe, Jason C. Crack, Debbie M. Hunt, Roger S. Buxton, Laura J. Smith, Nick E. Le Brun, Michael P. Williamson, Jeffrey Green
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Mycobacterium tuberculosis WhiB1 is a DNA-binding protein with a NO sensitive [4Fe-4S] cluster. Here the authors present the NMR structure of WhiB1 and suggest how loss of the iron-sulfur cluster through nitrosylation affects WhiB1 DNA binding and le
Externí odkaz:
https://doaj.org/article/a3161fc00cf1472d8753db514aa76e06
Autor:
Anne Volbeda, Erin L. Dodd, Claudine Darnault, Jason C. Crack, Oriane Renoux, Matthew I. Hutchings, Nick E. Le Brun, Juan C. Fontecilla-Camps
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
NsrR is a bacterial transcriptional regulator that acts as a nitric oxide (NO) sensor. Here, the authors present the crystal structure of NsrR, which reveals an unusual Fe-S cluster coordination and explains how NO exposure leads to the degradation o
Externí odkaz:
https://doaj.org/article/d75fcbfde85945c6bdbb68596b935661
Publikováno v:
Biographical Memoirs of Fellows of the Royal Society. 73:471-497
Andrew Thomson developed and exploited optical and magnetic resonance spectroscopy to address unresolved questions in biological inorganic chemistry, in a career that spanned more than 50 years. Despite his important role in the discovery of cisplati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72bb342bf48539ebbca4f77a66ff6c50
https://doi.org/10.1098/rsbm.2022.0006
https://doi.org/10.1098/rsbm.2022.0006