Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Nick Dekker"'
Autor:
AndréR.A. Marques, Mina Mirzaian, Hisako Akiyama, Patrick Wisse, Maria J. Ferraz, Paulo Gaspar, Karen Ghauharali-van der Vlugt, Rianne Meijer, Pilar Giraldo, Pilar Alfonso, Pilar Irún, Maria Dahl, Stefan Karlsson, Elena V. Pavlova, Timothy M. Cox, Saskia Scheij, Marri Verhoek, Roelof Ottenhoff, CindyP.A.A. van Roomen, Navraj S. Pannu, Marco van Eijk, Nick Dekker, Rolf G. Boot, Herman S. Overkleeft, Edward Blommaart, Yoshio Hirabayashi, Johannes M. Aerts
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 3, Pp 451-463 (2016)
The membrane lipid glucosylceramide (GlcCer) is continuously formed and degraded. Cells express two GlcCer-degrading β-glucosidases, glucocerebrosidase (GBA) and GBA2, located in and outside the lysosome, respectively. Here we demonstrate that throu
Externí odkaz:
https://doaj.org/article/57f08df9b338494281ce0b82ea7d752a
Autor:
Gertjan Kramer, Yvonne Woolerton, Jan P van Straalen, Johannes P C Vissers, Nick Dekker, James I Langridge, Robert J Beynon, Dave Speijer, Auguste Sturk, Johannes M F G Aerts
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0140097 (2015)
Quantitative proteomic analysis with mass spectrometry holds great promise for simultaneously quantifying proteins in various biosamples, such as human plasma. Thus far, studies addressing the reproducible measurement of endogenous protein concentrat
Externí odkaz:
https://doaj.org/article/e765ae7194e6476aa6a84e47a1344fa8
Autor:
Stefan Karlsson, Elena Pavlova, Susan Z. Wang, Johannes M. F. G. Aerts, Nick Dekker, Joy Archer, Timothy M. Cox
Publikováno v:
The Journal of Pathology. 231:88-97
Multiple myeloma and B cell lymphoma are leading causes of death in Gaucher's disease but the nature of the stimulus driving the often noted clonal expansion of immunoglobulin-secreting B cells and cognate lymphoid malignancy is unknown. We investiga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a408a2be09d6707029f35ce548b549f
https://doi.org/10.1002/path.4227
https://doi.org/10.1002/path.4227
Autor:
Nick Dekker, Johannes M. F. G. Aerts, Gabor E. Linthorst, Herman S. Overkleeft, Jeroen D. C. Codée, Mina Mirzaian, Johanna E. M. Groener, Ben J. H. M. Poorthuis, Gijs A. van der Marel, Maria J. Ferraz, Johan Lugtenburg, Henrik Gold
Publikováno v:
Clinical Chemistry
Clinical chemistry, 59(3), 547-556. American Association for Clinical Chemistry Inc.
Clinical Chemistry, 59(3), 547-556
Clinical chemistry, 59(3), 547-556. American Association for Clinical Chemistry Inc.
Clinical Chemistry, 59(3), 547-556
BACKGROUND Biochemical markers that accurately reflect the severity and progression of disease in patients with Fabry disease and their response to treatment are urgently needed. Globotriaosylsphingosine, also called lysoglobotriaosylceramide (lysoGb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfb25dd1ef75ea54545638798c40f1ef
https://doi.org/10.1373/clinchem.2012.192138
https://doi.org/10.1373/clinchem.2012.192138
Autor:
Herman S. Overkleeft, Johannes M. F. G. Aerts, Josanne Cox-Brinkman, Martin D. Witte, Carla E. M. Hollak, Johanna E. M. Groener, Gabor E. Linthorst, Ben J. H. M. Poorthuis, Wouter Wegdam, Rolf G. Boot, Mariëlle J. van Breemen, Nick Dekker, Henrik Gold, Gijs A. van der Marel, Gert Jan Kramer, Wouter W. Kallemeijn, Maria J. Ferraz, Saskia M. Rombach
Publikováno v:
Journal of Inherited Metabolic Disease, 34(3), 605-619. SPRINGER
Journal of inherited metabolic disease, 34(3), 605-619. Springer Netherlands
Journal of Inherited Metabolic Disease
Journal of inherited metabolic disease, 34(3), 605-619. Springer Netherlands
Journal of Inherited Metabolic Disease
A biomarker is an analyte indicating the presence of a biological process linked to the clinical manifestations and outcome of a particular disease. In the case of lysosomal storage disorders (LSDs), primary and secondary accumulating metabolites or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02c73b6ebdded2ece8c8ac7ab50ff9d0
https://doi.org/10.1007/s10545-011-9308-6
https://doi.org/10.1007/s10545-011-9308-6
Autor:
Susan Z. Wang, Elena Pavlova, Johannes M. F. G. Aerts, Stefan Karlsson, Nick Dekker, Timothy M. Cox, Joy Archer
Publikováno v:
Journal of pathology, 235(1), 113-124. John Wiley and Sons Ltd
Clonal B-cell proliferation is a frequent manifestation of Gaucher disease-a sphingolipidosis associated with a high risk of multiple myeloma and non-Hodgkin lymphoma. Gaucher disease is caused by genetic deficiency of acid -glucosidase, the natural
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a7b94d66b733cec4ca13dc8e4b0d82a
https://doi.org/10.1002/path.4452
https://doi.org/10.1002/path.4452
Autor:
Christian H. Grün, Johannes F.G. Vliegenthart, Alexander A. Nieuwland, Johannis P. Kamerling, Frans M. Klis, Frans Hochstenbach, Nick Dekker
Publikováno v:
FEBS Letters, 580(16), 3780-3786. Wiley-Blackwell
FEBS letters, 580(16), 3780-3786. Wiley-Blackwell
FEBS letters, 580(16), 3780-3786. Wiley-Blackwell
(1-->3)-alpha-glucanases catalyze the hydrolysis of fungal cell wall (1-->3)-alpha-glucan, and function during cell division of yeasts containing this cell wall component or act in mycoparasitic processes. Here, we characterize the mechanism of actio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a24dd372139acd0912a2196e03481ea6
https://doi.org/10.1016/j.febslet.2006.05.062
https://doi.org/10.1016/j.febslet.2006.05.062
Publikováno v:
FEBS letters, 580(13), 3099-3106. Wiley-Blackwell
During the final stage of the cell division cycle in the fission yeast Schizosaccharomyces pombe , transcription factor Ace2p activates expression of genes involved in the separation of newly formed daughter cells, such as agn1 + , which encodes the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5ab0fc75e5c7719ba77ceea782b8a8f
https://doi.org/10.1016/j.febslet.2006.04.061
https://doi.org/10.1016/j.febslet.2006.04.061
Autor:
Marlene van den Berg, Nick Dekker, Frans Hochstenbach, Christian H. Grün, Dave Speijer, Annett de Haan
Publikováno v:
Molecular biology of the cell, 15(8), 3903-3914. American Society for Cell Biology
Cell division in the fission yeast Schizosaccharomyces pombe yields two equal-sized daughter cells. Medial fission is achieved by deposition of a primary septum flanked by two secondary septa within the dividing cell. During the final step of cell di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aed46db8eab078e4720909edea524685
https://doi.org/10.1091/mbc.e04-04-0319
https://doi.org/10.1091/mbc.e04-04-0319
Autor:
Rolf G. Boot, Nick Dekker, Mina Mirzaian, Patrick Wisse, Johannes M. F. G. Aerts, Wilma E. Donker-Koopman, Maria J. Ferraz, Gert Jan Kramer, Marri Verhoek, Herman S. Overkleeft, Henrik Gold
Publikováno v:
Blood cells, moleculesdiseases. 54(4)
Deficiency of glucocerebrosidase (GBA) leads to Gaucher disease (GD), an inherited disorder characterised by storage of glucosylceramide (GlcCer) in lysosomes of tissue macrophages. Recently, we reported marked increases of deacylated GlcCer, named g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c952d734d80bebac424e7ca098c7ef8
https://pubmed.ncbi.nlm.nih.gov/25842368
https://pubmed.ncbi.nlm.nih.gov/25842368