Zobrazeno 1 - 10
of 913
pro vyhledávání: '"Nick C. Fox"'
Autor:
Anna Hofmann, Lisa M. Häsler, Marius Lambert, Stephan A. Kaeser, Susanne Gräber-Sultan, Ulrike Obermüller, Elke Kuder-Buletta, Christian la Fougere, Christoph Laske, Jonathan Vöglein, Johannes Levin, Nick C. Fox, Natalie S. Ryan, Henrik Zetterberg, Jorge J. Llibre-Guerra, Richard J. Perrin, Laura Ibanez, Peter R. Schofield, William S. Brooks, Gregory S. Day, Martin R. Farlow, Ricardo F. Allegri, Patricio Chrem Mendez, Takeshi Ikeuchi, Kensaku Kasuga, Jae-Hong Lee, Jee Hoon Roh, Hiroshi Mori, Francisco Lopera, Randall J. Bateman, Eric McDade, Brian A. Gordon, Jasmeer P. Chhatwal, Mathias Jucker, Stephanie A. Schultz, Dominantly Inherited Alzheimer Network
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Disease-modifying therapies for Alzheimer’s disease (AD) are likely to be most beneficial when initiated in the presymptomatic phase. To track the benefit of such interventions, fluid biomarkers are of great importance, with neurofilament
Externí odkaz:
https://doaj.org/article/0a454b50306942c5b151db45a71682b3
Autor:
Juan Lantero-Rodriguez, Elena Camporesi, Laia Montoliu-Gaya, Johan Gobom, Diana Piotrowska, Maria Olsson, Irena Matečko Burmann, Bruno Becker, Ann Brinkmalm, Björn M. Burmann, Michael Perkinton, Nicholas J. Ashton, Nick C. Fox, Tammaryn Lashley, Henrik Zetterberg, Kaj Blennow, Gunnar Brinkmalm
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-25 (2024)
Abstract Abnormal accumulation of misfolded and hyperphosphorylated tau protein in brain is the defining feature of several neurodegenerative diseases called tauopathies, including Alzheimer’s disease (AD). In AD, this pathological change is reflec
Externí odkaz:
https://doaj.org/article/07ce566d50b649798807723349e5fe2c
Autor:
Heidi Murray-Smith, Suzie Barker, Frederik Barkhof, Josephine Barnes, Thomas M. Brown, Gabriella Captur, Molly R.E.Cartlidge, David M. Cash, William Coath, Daniel Davis, John C. Dickson, James Groves, Alun D. Hughes, Sarah-Naomi James, Ashvini Keshavan, Sarah E. Keuss, Josh King-Robson, Kirsty Lu, Ian B. Malone, Jennifer M. Nicholas, Alicja Rapala, Catherine J. Scott, Rebecca Street, Carole H. Sudre, David L. Thomas, Andrew Wong, Selina Wray, Henrik Zetterberg, Nishi Chaturvedi, Nick C. Fox, Sebastian J. Crutch, Marcus Richards, Jonathan M. Schott
Publikováno v:
BMC Neurology, Vol 24, Iss 1, Pp 1-21 (2024)
Abstract Background Although age is the biggest known risk factor for dementia, there remains uncertainty about other factors over the life course that contribute to a person’s risk for cognitive decline later in life. Furthermore, the pathological
Externí odkaz:
https://doaj.org/article/9fdd7c07f6e74bf4bc709c0fc60fb7cd
Autor:
Stephanie Doering, Austin McCullough, Brian A. Gordon, Charles D. Chen, Nicole McKay, Diana Hobbs, Sarah Keefe, Shaney Flores, Jalen Scott, Hunter Smith, Stephen Jarman, Kelley Jackson, Russ C. Hornbeck, Beau M. Ances, Chengjie Xiong, Andrew J. Aschenbrenner, Jason Hassenstab, Carlos Cruchaga, Alisha Daniels, Randall J. Bateman, John C. Morris, Tammie L.S. Benzinger, James M. Noble, Gregory S. Day, Neill R. Graff-Radford, Jonathan Voglein, Johannes Levin, Ricardo F. Allegri, Patricio Chrem Mendez, Ezequiel Surace, Sarah B. Berman, Snezana Ikonomovic, Neelesh K. Nadkarni, Francisco Lopera, Laura Ramirez, David Aguillon, Yudy Leon, Claudia Ramos, Diana Alzate, Ana Baena, Natalia Londono, Sonia Moreno, Mathias Jucker, Christoph Laske, Elke Kuder-Buletta, Susanne Graber-Sultan, Oliver Preische, Anna Hofmann, Takeshi Ikeuchi, Kensaku Kasuga, Yoshiki Niimi, Kenji Ishii, Michio Senda, Raquel Sanchez-Valle, Pedro Rosa-Neto, Nick C. Fox, Dave Cash, Jae-Hong Lee, Jee Hoon Roh, Stephen Salloway, Meghan C. Riddle, William Menard, Courtney Bodge, Mustafa Surti, Leonel Tadao Takada, Martin Farlow, Jasmeer P. Chhatwal, V.J. Sanchez-Gonzalez, Maribel Orozco-Barajas, Alison M. Goate, Alan E. Renton, Bianca T. Esposito, Celeste M. Karch, Jacob Marsh, Victoria Fernanadez, Anne M. Fagan, Gina Jerome, Elizabeth Herries, Jorge Llibre-Guerra, Allan I. Levey, Erik C.B. Johnson, Nicholas T. Seyfried, Peter R. Schofield, William S. Brooks, Jacob A. Bechara, Randall Bateman, Eric McDade, Richard J. Perrin, Erin E. Franklin, Tammie Benzinger, Allison Chen, Charles Chen, Nelly Friedrichsen, Brian Gordon, Nancy Hantler, Russ Hornbeck, Steve Jarman, Deborah Koudelis, Parinaz Massoumzadeh, Joyce Nicklaus, Christine Pulizos, Qing Wang, Sheetal Mishall, Edita Sabaredzovic, Emily Deng, Madison Candela, Peter Wang, Xiong Xu, Yan Li, Emily Gremminger, Yinjiao Ma, Ryan Bui, Ruijin Lu, Ralph Martins, Ana Luisa Sosa Ortiz, Laura Courtney, Hiroshi Mori, Charlene Supnet-Bell, Jinbin Xu, John Ringman, Nicolas Barthelemy, John Morris, Jennifer Smith
Publikováno v:
EBioMedicine, Vol 103, Iss , Pp 105080- (2024)
Summary: Background: Neuroimaging studies often quantify tau burden in standardized brain regions to assess Alzheimer disease (AD) progression. However, this method ignores another key biological process in which tau spreads to additional brain regio
Externí odkaz:
https://doaj.org/article/0b7b8db8958a47c9b99946f7b5107ddb
Autor:
Sarah-Naomi James, Carole Sudre, Nick C Fox, Marcus Richards, Alun Hughes, Josephine Barnes, Jonathan M Schott
Publikováno v:
Cerebral Circulation - Cognition and Behavior, Vol 6, Iss , Pp 100262- (2024)
Introduction: Data drawn from the 1946 British birth cohort is opportunistically placed to address how midlife cardiac and vascular structure is linked with white matter brain health later in life, given that participants are born in the same week; h
Externí odkaz:
https://doaj.org/article/db444a48760f4e4183745a0cf24f8f18
Autor:
Antoinette O’Connor, David M. Cash, Teresa Poole, Pawel J. Markiewicz, Maggie R. Fraser, Ian B. Malone, Jieqing Jiao, Philip S. J. Weston, Shaney Flores, Russ Hornbeck, Eric McDade, Michael Schöll, Brian A. Gordon, Randall J. Bateman, Tammie L. S. Benzinger, Nick C. Fox
Publikováno v:
Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-11 (2023)
Abstract Cortical tau accumulation is a key pathological event that partly defines Alzheimer’s disease (AD) onset and is associated with cognitive decline and future disease progression. However, an improved understanding of the timing and pattern
Externí odkaz:
https://doaj.org/article/555f699f8f0e43d889b6f8d82c8b8ed1
Autor:
Rebecca E. Green, Jodie Lord, Marzia A. Scelsi, Jin Xu, Andrew Wong, Sarah Naomi-James, Alex Handy, Lachlan Gilchrist, Dylan M. Williams, Thomas D. Parker, Christopher A. Lane, Ian B. Malone, David M. Cash, Carole H. Sudre, William Coath, David L. Thomas, Sarah Keuss, Richard Dobson, Cristina Legido-Quigley, Nick C. Fox, Jonathan M. Schott, Marcus Richards, Petroula Proitsi, The Insight 46 study team
Publikováno v:
Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-13 (2023)
Abstract Background Identifying blood-based signatures of brain health and preclinical pathology may offer insights into early disease mechanisms and highlight avenues for intervention. Here, we systematically profiled associations between blood meta
Externí odkaz:
https://doaj.org/article/f5a5b80764c34bc1b3fd5049c6dcb527
Autor:
Charlotte Warren‐Gash, Sharon L. Cadogan, Jennifer M. Nicholas, Judith M. Breuer, Divya Shah, Neil Pearce, Suhail Shiekh, Liam Smeeth, Martin R. Farlow, Hiroshi Mori, Brian A. Gordon, Georg Nuebling, Eric McDade, Randall J. Bateman, Peter R. Schofield, Jae‐Hong Lee, John C. Morris, David M. Cash, Nick C. Fox, Basil H. Ridha, Martin N. Rossor, for the Dominantly Inherited Alzheimer Network
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 9, Iss 11, Pp 1727-1738 (2022)
Abstract Objective To investigate whether herpes simplex virus type 1 (HSV‐1) infection was associated with rates of cognitive decline or whole brain atrophy among individuals from the Dominantly Inherited Alzheimer Network (DIAN). Methods Among tw
Externí odkaz:
https://doaj.org/article/6365c17a3e4a4713927eeb6fdeb7543a
Autor:
William Coath, Marc Modat, M. Jorge Cardoso, Pawel J. Markiewicz, Christopher A. Lane, Thomas D. Parker, Ashvini Keshavan, Sarah M. Buchanan, Sarah E. Keuss, Matthew J. Harris, Ninon Burgos, John Dickson, Anna Barnes, David L. Thomas, Daniel Beasley, Ian B. Malone, Andrew Wong, Kjell Erlandsson, Benjamin A. Thomas, Michael Schöll, Sebastien Ourselin, Marcus Richards, Nick C. Fox, Jonathan M. Schott, David M. Cash, for the Alzheimer's Disease Neuroimaging Initiative
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 15, Iss 2, Pp n/a-n/a (2023)
Abstract INTRODUCTION The Centiloid scale aims to harmonize amyloid beta (Aβ) positron emission tomography (PET) measures across different analysis methods. As Centiloids were created using PET/computerized tomography (CT) data and are influenced by
Externí odkaz:
https://doaj.org/article/89fc878da77c45b0abc21824ecd8a625
Autor:
Alexis Moscoso, Melissa C. Wren, Tammaryn Lashley, Erik Arstad, Melissa E. Murray, Nick C. Fox, Kerstin Sander, Michael Schöll
Publikováno v:
Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-5 (2022)
Externí odkaz:
https://doaj.org/article/483bdb8b9982482da2936b48f6819fa4