Zobrazeno 1 - 10
of 154
pro vyhledávání: '"Nick Barker"'
Autor:
Lana Kostic, Carly Leung, Katzrin Ahmad Murad, Snezhina Kancheva, Stefano Perna, Bernett Lee, Nick Barker
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract The existence and function of Lgr5+ cells within the developing esophagus remains unknown. Here, we document multiple discrete Lgr5+ populations in the developing mouse esophagus, predominantly within nascent epithelial and external muscle l
Externí odkaz:
https://doaj.org/article/7da14a583d2d4bfcb2a3c01069b33b52
Publikováno v:
STAR Protocols, Vol 3, Iss 2, Pp 101411- (2022)
Summary: Intestinal cells marked by Lgr5 function as tissue-resident stem cells that sustain the homeostatic replenishment of the epithelium. By incorporating a diphtheria toxin receptor (DTR) cassette linked to the Lgr5 coding region, native Lgr5-ex
Externí odkaz:
https://doaj.org/article/96750d58c24b4c90aba6f4628f872565
Autor:
Ryo Seishima, Carly Leung, Swathi Yada, Katzrin Bte Ahmed Murad, Liang Thing Tan, Amin Hajamohideen, Si Hui Tan, Hideki Itoh, Kazuhiro Murakami, Yoshihiro Ishida, Satoshi Nakamizo, Yusuke Yoshikawa, Esther Wong, Nick Barker
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Uterine gland development is essential for successful embryo implantation, decidua formation and placental development. Here the authors demonstrate that neonatal Wnt-dependent Lgr5 expressing stem/progenitor cells at the tips of developing glands ar
Externí odkaz:
https://doaj.org/article/f5147bce6d4b4b9782f63d84b4e894c4
Autor:
Dustin J. Flanagan, Nick Barker, Cameron Nowell, Hans Clevers, Matthias Ernst, Toby J. Phesse, Elizabeth Vincan
Publikováno v:
Disease Models & Mechanisms, Vol 10, Iss 8, Pp 971-980 (2017)
The gastric epithelium consists of tubular glandular units, each containing several differentiated cell types, and populations of stem cells, which enable the stomach to secrete the acid, mucus and various digestive enzymes required for its function.
Externí odkaz:
https://doaj.org/article/2381956ca6794b32b26910fb07d9dc46
Autor:
Patrizia Cammareri, Aidan M. Rose, David F. Vincent, Jun Wang, Ai Nagano, Silvana Libertini, Rachel A. Ridgway, Dimitris Athineos, Philip J. Coates, Angela McHugh, Celine Pourreyron, Jasbani H. S. Dayal, Jonas Larsson, Simone Weidlich, Lindsay C. Spender, Gopal P. Sapkota, Karin J. Purdie, Charlotte M. Proby, Catherine A. Harwood, Irene M. Leigh, Hans Clevers, Nick Barker, Stefan Karlsson, Catrin Pritchard, Richard Marais, Claude Chelala, Andrew P. South, Owen J. Sansom, Gareth J. Inman
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Cutaneous squamous cell carcinomas is a growing problem but the driver genes causing this remain poorly defined. Here, the authors demonstrate that inactivating driver mutations in TGFBR1 and TGFBR2occur in vemurafenib-induced and sporadic cutaneous
Externí odkaz:
https://doaj.org/article/007e4295faa9467ba2f947c4d342dc0a
Autor:
Dustin J. Flanagan, Toby J. Phesse, Nick Barker, Renate H.M. Schwab, Nancy Amin, Jordane Malaterre, Daniel E. Stange, Cameron J. Nowell, Scott A. Currie, Jarel T.S. Saw, Eva Beuchert, Robert G. Ramsay, Owen J. Sansom, Matthias Ernst, Hans Clevers, Elizabeth Vincan
Publikováno v:
Stem Cell Reports, Vol 4, Iss 5, Pp 759-767 (2015)
The mammalian adult small intestinal epithelium is a rapidly self-renewing tissue that is maintained by a pool of cycling stem cells intermingled with Paneth cells at the base of crypts. These crypt base stem cells exclusively express Lgr5 and requir
Externí odkaz:
https://doaj.org/article/d047e533dc0745429300467c60cd988a
Publikováno v:
Biomedicines, Vol 7, Iss 3, p 50 (2019)
The extreme chemical and mechanical forces endured by the gastrointestinal tract drive a constant renewal of the epithelial lining. Stem cells of the intestine and stomach, marked by the cell surface receptor Lgr5, preserve the cellular status-quo of
Externí odkaz:
https://doaj.org/article/876d3b67b2524aea9069fbbb983dfd07
Autor:
Nawaphat Jangphattananont, Hiroki Sato, Ryu Imamura, Katsuya Sakai, Yumi Terakado, Kazuhiro Murakami, Nick Barker, Hiroko Oshima, Masanobu Oshima, Junichi Takagi, Yukinari Kato, Seiji Yano, Kunio Matsumoto
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 12, p 2955 (2019)
Hepatocyte growth factor (HGF) is secreted as an inactive single-chain HGF (scHGF); however, only proteolytically processed two-chain HGF (tcHGF) can activate the MET receptor. We investigated the localization of tcHGF and activated/phosphorylated ME
Externí odkaz:
https://doaj.org/article/05cf928af4e843fcb72a7acd52f16208
Publikováno v:
Cell Reports, Vol 5, Iss 2, Pp 349-356 (2013)
The pyloric epithelium continuously self-renews throughout life, driven by limited reservoirs of resident Lgr5+ adult stem cells. Here, we characterize the population dynamics of these stem cells during epithelial homeostasis. Using a clonal fate-map
Externí odkaz:
https://doaj.org/article/c22dbe7c18854d9faebb08948b83ce68
Autor:
Nick Barker, Maarten B. Rookmaaker, Pekka Kujala, Annie Ng, Marc Leushacke, Hugo Snippert, Marc van de Wetering, Shawna Tan, Johan H. Van Es, Meritxell Huch, Richard Poulsom, Marianne C. Verhaar, Peter J. Peters, Hans Clevers
Publikováno v:
Cell Reports, Vol 2, Iss 3, Pp 540-552 (2012)
Multipotent stem cells and their lineage-restricted progeny drive nephron formation within the developing kidney. Here, we document expression of the adult stem cell marker Lgr5 in the developing kidney and assess the stem/progenitor identity of Lgr5
Externí odkaz:
https://doaj.org/article/080bb29615104b7eb96138775e7cda62