Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Nick Warr"'
Autor:
Laura Santini, Florian Halbritter, Fabian Titz-Teixeira, Toru Suzuki, Maki Asami, Xiaoyan Ma, Julia Ramesmayer, Andreas Lackner, Nick Warr, Florian Pauler, Simon Hippenmeyer, Ernest Laue, Matthias Farlik, Christoph Bock, Andreas Beyer, Anthony C. F. Perry, Martin Leeb
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
In most mammals, imprinted genes contain epigenetic marks that differ in each parental genome and control their parent-of-origin-specific expression. Here, the authors map imprinted genes in mouse preimplantation embryos and find that imprinted gene
Externí odkaz:
https://doaj.org/article/80a4a9c1e8f242dab49a92d2bed3b3ac
Autor:
Nick Warr, Pam Siggers, Joel May, Nicolas Chalon, Madeleine Pope, Sara Wells, Marie-Christine Chaboissier, Andy Greenfield
Publikováno v:
Reproduction
Reproduction, 2022, 163, pp.333-340. ⟨10.1530/REP-21-0443⟩
Reproduction, 2022, 163, pp.333-340. ⟨10.1530/REP-21-0443⟩
Sex determination in mammals is controlled by the dominance of either pro-testis (SRY-SOX9-FGF9) or pro-ovary (RSPO1-WNT4-FOXL2) genetic pathways during early gonad development in XY and XX embryos, respectively. We have previously shown that early,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44d49f94595e554086181111647750e3
https://hal.science/hal-03650971
https://hal.science/hal-03650971
Autor:
Michelle Simon, Matthew Mackenzie, Sare Betul Kaygusuz, Zehra Yavas Abali, Busra Gurpinar Tosun, Hatice Kocak Eker, Nihal Hatipoglu, Sukran Poyrazoglu, Didem Helvacioglu, Mehmet Eltan, Firdevs Bas, Gozde Yesil, Gul Direk, Tuba Seven Menevse, Abdullah Bereket, Andy Greenfield, Lydia Teboul, Dilek Çiçek, Tulay Guran, Richard Reeves, Serap Turan, Nick Warr, Feyza Darendeliler
Publikováno v:
European Journal of Endocrinology
Context Homozygous and heterozygous variants in PPP2R3C are associated with syndromic 46,XY complete gonadal dysgenesis (Myo-Ectodermo-Gonadal Dysgenesis (MEGD) syndrome), and impaired spermatogenesis, respectively. This study expands the role of PPP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fa57bd6bd3a6729eeb372c3600715ed
https://avesis.kayseri.edu.tr/publication/details/58cbde97-66b0-4e72-970c-81619c50e2ea/oai
https://avesis.kayseri.edu.tr/publication/details/58cbde97-66b0-4e72-970c-81619c50e2ea/oai
Autor:
Pam Siggers, Gwenn-Aël Carré, Debora Bogani, Nick Warr, Sara Wells, Helen Hilton, Chris Esapa, Mohammad K Hajihosseini, Andy Greenfield
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e100447 (2014)
The secreted molecule fibroblast growth factor 9 (FGF9) plays a critical role in testis determination in the mouse. In embryonic gonadal somatic cells it is required for maintenance of SOX9 expression, a key determinant of Sertoli cell fate. Conditio
Externí odkaz:
https://doaj.org/article/b46f7a2ea5db4085af07bdc27de8d884
Autor:
Martin Leeb, Simon Hippenmeyer, Florian M. Pauler, Matthias Farlik, Perry Acf, Maki Asami, Ernest D. Laue, Toru Suzuki, Laura Santini, Florian Halbritter, Nick Warr, Xiaoyan Ma, Julia Ramesmayer, Andreas Beyer, Fabian Titz-Teixeira, Andreas Lackner, Christoph Bock
In mammals, chromatin marks at imprinted genes are asymmetrically inherited to control parentally-biased gene expression. This control is thought predominantly to involve parent-specific differentially methylated regions (DMR) in genomic DNA. However
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ba0d276fec465b078c5e9cd165a4673
https://doi.org/10.1101/2020.11.03.366948
https://doi.org/10.1101/2020.11.03.366948
Autor:
Tiphanie Merel, Matthieu Peycelon, Serge Nef, Daisylyn Senna Tan, Evgenia Globa, Rita Bertalan, Inas Mazen, John C. Achermann, Andy Greenfield, Romain Le Ru, Jean-Pierre Siffroi, Anne Jorgensen, Ken McElreavey, Ágnes Sallai, Brigitte Mignot, Ralf Jauch, Laetitia Martinerie, Raissa G. G. Kay, Gerard S. Conway, Joelle Bignon-Topalovic, Juliane Léger, Nick Warr, Denis Houzelstein, Federica Buonocore, Anu Bashamboo, Raja Brauner, Caroline Eozenou, Lionel Van Maldergem, Yuliya Shcherbak, Jean-Claude Carel
Publikováno v:
Genetics in Medicine
Genetics in Medicine, Nature Publishing Group, 2020, 22 (1), pp.150-159. ⟨10.1038/s41436-019-0606-y⟩
Genetics in Medicine, Nature Publishing Group, In press, ⟨10.1038/s41436-019-0606-y⟩
Genetics in Medicine (2019)
Genetics in Medicine, 2020, 22 (1), pp.150-159. ⟨10.1038/s41436-019-0606-y⟩
Genetics in Medicine, Nature Publishing Group, 2020, 22 (1), pp.150-159. ⟨10.1038/s41436-019-0606-y⟩
Genetics in Medicine, Nature Publishing Group, In press, ⟨10.1038/s41436-019-0606-y⟩
Genetics in Medicine (2019)
Genetics in Medicine, 2020, 22 (1), pp.150-159. ⟨10.1038/s41436-019-0606-y⟩
International audience; PURPOSE:XY individuals with disorders/differences of sex development (DSD) are characterized by reduced androgenization caused, in some children, by gonadal dysgenesis or testis regression during fetal development. The genetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b8f7f93f0dd958aeec82a17aa535799
https://hal-pasteur.archives-ouvertes.fr/pasteur-02376177
https://hal-pasteur.archives-ouvertes.fr/pasteur-02376177
Autor:
Nick Warr, Sara Wells, Lydia Teboul, Maki Asami, Toru Suzuki, Joel May, Anthony C.F. Perry, Andy Greenfield
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-7 (2018)
Scientific Reports
Scientific Reports
Bacterial artificial chromosomes (BACs) offer a means of manipulating gene expression and tagging gene products in the mammalian genome without the need to alter endogenous gene structure and risk deleterious phenotypic consequences. However, for a B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c63ef3a83718949bbffd27ec0c2387a5
http://link.springer.com/article/10.1038/s41598-018-35458-5
http://link.springer.com/article/10.1038/s41598-018-35458-5
Autor:
Silvia Corrochano, Abigail Harris, Hans Clevers, Caroline Eozenou, Isabelle Stévant, Joelle Bignon-Topalovic, Nick Warr, Neila Belguith, Sara Wells, Bochra Ben Rhouma, Pam Siggers, Serge Nef, Daniel T. Grimes, Ken McElreavey, Rebecca D. Burdine, Feng Cong, Makoto Suzuki, Andy Greenfield, Danielle Sagar, Anu Bashamboo, Bon-Kyoung Koo, Raja Brauner
Publikováno v:
Proceedings of the National Academy of Sciences, Vol. 115, No 21 (2018) pp. 5474-5479
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2018, 115 (21), pp.5474-5479. ⟨10.1073/pnas.1801223115⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2018, 115 (21), pp.5474-5479. ⟨10.1073/pnas.1801223115⟩
Proceedings of the National Academy of Sciences of the United States of America, 115(21), 5474
Proceedings of the National Academy of Sciences of the United States of America, 115(21), 5474-5479. National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2018, 115 (21), pp.5474-5479. ⟨10.1073/pnas.1801223115⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2018, 115 (21), pp.5474-5479. ⟨10.1073/pnas.1801223115⟩
Proceedings of the National Academy of Sciences of the United States of America, 115(21), 5474
Proceedings of the National Academy of Sciences of the United States of America, 115(21), 5474-5479. National Academy of Sciences
International audience; Mammalian sex determination is controlled by the antagonistic interactions of two genetic pathways: The SRY-SOX9-FGF9 network promotes testis determination partly by opposing proovarian pathways, while RSPO1/WNT-β-catenin/FOX
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f785b7c346bbb98027161ca7382405e7
https://hdl.handle.net/20.500.11755/a85a814a-a5a7-4064-9ca8-516f15a8bb58
https://hdl.handle.net/20.500.11755/a85a814a-a5a7-4064-9ca8-516f15a8bb58
Autor:
Nick Warr, Debora Bogani, Pam Siggers, Rachel Brixey, Hilda Tateossian, Asha Dopplapudi, Sara Wells, Michael Cheeseman, Ying Xia, Harry Ostrer, Andy Greenfield
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e19572 (2011)
In mammals, the Y chromosome is a dominant male determinant, causing the bipotential gonad to develop as a testis. Recently, cases of familial and spontaneous 46,XY disorders of sex development (DSD) have been attributed to mutations in the human gen
Externí odkaz:
https://doaj.org/article/90c4c456a12b4bcdaab8107f57443116
Autor:
Debora Bogani, Pam Siggers, Rachel Brixey, Nick Warr, Sarah Beddow, Jessica Edwards, Debbie Williams, Dagmar Wilhelm, Peter Koopman, Richard A Flavell, Hongbo Chi, Harry Ostrer, Sara Wells, Michael Cheeseman, Andy Greenfield
Publikováno v:
PLoS Biology, Vol 7, Iss 9, p e1000196 (2009)
Sex determination in mammals is controlled by the presence or absence of the Y-linked gene SRY. In the developing male (XY) gonad, sex-determining region of the Y (SRY) protein acts to up-regulate expression of the related gene, SOX9, a transcription
Externí odkaz:
https://doaj.org/article/c8776f4de498418bbb421a64b4c2a399