Zobrazeno 1 - 10
of 202
pro vyhledávání: '"Nick, Powell"'
Autor:
Jonathan W. Lo, Jan-Hendrik Schroeder, Luke B. Roberts, Rami Mohamed, Domenico Cozzetto, Gordon Beattie, Omer S. Omer, Ellen M. Ross, Frank Heuts, Geraldine M. Jowett, Emily Read, Matthew Madgwick, Joana F. Neves, Tamas Korcsmaros, Richard G. Jenner, Lucy S. K. Walker, Nick Powell, Graham M. Lord
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract The maintenance of intestinal homeostasis is a fundamental process critical for organismal integrity. Sitting at the interface of the gut microbiome and mucosal immunity, adaptive and innate lymphoid populations regulate the balance between
Externí odkaz:
https://doaj.org/article/9c1706884f1e46cd8fa10a092e27a500
Autor:
Anke Liebert, Michael Shapiro, Muralidhara Rao Maradana, Ying Li, Nick Powell, Matthias Zilbauer, Brigitta Stockinger
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 17, Iss 3, Pp 507-510 (2024)
Externí odkaz:
https://doaj.org/article/7896bc5a6b37468ba8bd5a37b43ea651
Autor:
Peter M Irving, Miles Parkes, Ruth Wood, Ailsa L Hart, Nicholas A Kennedy, Nick Powell, Julian R Marchesi, Tariq Ahmad, Tim Raine, Andrew King, James O Lindsay, Kevin Whelan, Charlie W Lees, Christopher A Lamb, Jack Satsangi, Emma Clark, Shriya Sharma, Xinyue Zhang, Christopher J Stewart, Naomi McGregor, Helen C Hancock, Rebecca H Maier, John C Mansfield, Mary Doona, Michelle Bardgett, Natalie J Prescott, Trevor Liddle, Robert Lees, Hannah Watson, Carl A Anderson, Ally Speight, Ciara Kennedy, Sarah Lawrence, Nicola J Wyatt, Jennifer A Doyle, Rebecca E McIntyre, Luke Jostins-Dean, Victoria Hildreth, James MS Wason, Dean Allerton, Dawn Clewes, Cristina Cotobal Martin, Katherine Frith, Sameena Iqbal, Laura Letchford, Jasmin Ostermayer, Tolulope Osunnuyi, Tara Shrestha, Michelle Strickland, Gregory R Young
Publikováno v:
BMJ Open, Vol 14, Iss 4 (2024)
Introduction Characterised by chronic inflammation of the gastrointestinal tract, inflammatory bowel disease (IBD) symptoms including diarrhoea, abdominal pain and fatigue can significantly impact patient’s quality of life. Therapeutic developments
Externí odkaz:
https://doaj.org/article/12bb87e0caee4e31a4d86e9b0e5adbdd
Autor:
Nick Powell, Mark R Thursz, Kevin J Woollard, James Larkin, Samra Turajlic, Stephen R Atkinson, Robert D Goldin, Evangelos Triantafyllou, Lucia A Possamai, Charalambos G Antoniades, Cathrin L C Gudd, Eoin Mitchell, Marie-Anne Mawhin
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 4 (2024)
Background Checkpoint inhibitor-induced hepatitis (CPI-hepatitis) is an emerging problem with the widening use of CPIs in cancer immunotherapy. Here, we developed a mouse model to characterize the mechanism of CPI-hepatitis and to therapeutically tar
Externí odkaz:
https://doaj.org/article/ef7d49df3e824b6ba015b5adda0e950e
Autor:
Jonathan W. Lo, Domenico Cozzetto, James L. Alexander, Nathan P. Danckert, Matthew Madgwick, Naomi Knox, Jillian Yong Xin Sieh, Marton Olbei, Zhigang Liu, Hajir Ibraheim, Jesus Miguens Blanco, Hiromi Kudo, Rocio Castro Seoane, Lucia A. Possamai, Robert Goldin, Julian Marchesi, Tamas Korcsmaros, Graham M. Lord, Nick Powell
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Immune checkpoint inhibitors (CPIs) are a relatively newly licenced cancer treatment, which make a once previously untreatable disease now amenable to a potential cure. Combination regimens of anti-CTLA4 and anti-PD-1 show enhanced efficacy
Externí odkaz:
https://doaj.org/article/e664d0e3c68643ff903f07ec1b951c4e
Autor:
Polychronis Pavlidis, Anastasia Tsakmaki, Eirini Pantazi, Katherine Li, Domenico Cozzetto, Jonathan Digby- Bell, Feifei Yang, Jonathan W. Lo, Elena Alberts, Ana Caroline Costa Sa, Umar Niazi, Joshua Friedman, Anna K. Long, Yuchun Ding, Christopher D. Carey, Christopher Lamb, Mansoor Saqi, Matthew Madgwick, Leila Gul, Agatha Treveil, Tamas Korcsmaros, Thomas T. Macdonald, Graham M. Lord, Gavin Bewick, Nick Powell
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Mechanisms of non-response to ustekinumab, a biologic targeting IL-23, are currently unclear. Here, the authors show that the transcriptional program regulated by IL-22, an IL-23 responsive cytokine, is enriched in patients with ulcerative colitis un
Externí odkaz:
https://doaj.org/article/09b1e8f2868c4b6694a41d33bf89af3b
Autor:
Jan-Hendrik Schroeder, Gordon Beattie, Jonathan W. Lo, Tomasz Zabinski, Nick Powell, Joana F. Neves, Richard G. Jenner, Graham M. Lord
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Huge progress has been made in understanding the biology of innate lymphoid cells (ILC) by adopting several well-known concepts in T cell biology. As such, flow cytometry gating strategies and markers, such as CD90, have been applied to indentify ILC
Externí odkaz:
https://doaj.org/article/51f45fc4faa84fa3900e89aef90a55fc
Autor:
Simeng Lin, Nicholas A. Kennedy, Aamir Saifuddin, Diana Muñoz Sandoval, Catherine J. Reynolds, Rocio Castro Seoane, Sherine H. Kottoor, Franziska P. Pieper, Kai-Min Lin, David K. Butler, Neil Chanchlani, Rachel Nice, Desmond Chee, Claire Bewshea, Malik Janjua, Timothy J. McDonald, Shaji Sebastian, James L. Alexander, Laura Constable, James C. Lee, Charles D. Murray, Ailsa L. Hart, Peter M. Irving, Gareth-Rhys Jones, Klaartje B. Kok, Christopher A. Lamb, Charlie W. Lees, Daniel M. Altmann, Rosemary J. Boyton, James R. Goodhand, Nick Powell, Tariq Ahmad, CLARITY IBD study
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Vaccination is effective in protecting from COVID-19. Here the authors report immune responses and breakthrough infections in twice-vaccinated patients receiving anti-TNF treatments for inflammatory bowel disease, and find dampened vaccine responses
Externí odkaz:
https://doaj.org/article/ff70757914a74e03bae010a63c866cc8
Autor:
James L. Alexander, Benjamin H. Mullish, Nathan P. Danckert, Zhigang Liu, Marton L. Olbei, Aamir Saifuddin, Melissa Torkizadeh, Hajir Ibraheim, Jesús Miguéns Blanco, Lauren A. Roberts, Claire M. Bewshea, Rachel Nice, Simeng Lin, Hemanth Prabhudev, Caroline Sands, Verena Horneffer-van der Sluis, Matthew Lewis, Shaji Sebastian, Charlie W. Lees, Julian P. Teare, Ailsa Hart, James R. Goodhand, Nicholas A. Kennedy, Tamas Korcsmaros, Julian R. Marchesi, Tariq Ahmad, Nick Powell
Publikováno v:
EBioMedicine, Vol 88, Iss , Pp 104430- (2023)
Summary: Background: Patients with inflammatory bowel disease (IBD) treated with anti-TNF therapy exhibit attenuated humoral immune responses to vaccination against SARS-CoV-2. The gut microbiota and its functional metabolic output, which are perturb
Externí odkaz:
https://doaj.org/article/81748891479c4744b4c014c27869b064
Autor:
Grace L. Burns, Jessica K. Bruce, Kyra Minahan, Andrea Mathe, Thomas Fairlie, Raquel Cameron, Crystal Naudin, Prema M. Nair, Michael D. E. Potter, Mudar Zand Irani, Steven Bollipo, Robert Foster, Lay T. Gan, Ayesha Shah, Natasha A. Koloski, Paul S. Foster, Jay C. Horvat, Martin Veysey, Gerald Holtmann, Nick Powell, Marjorie M. Walker, Nicholas J. Talley, Simon Keely
Publikováno v:
Frontiers in Immunology, Vol 13 (2023)
BackgroundFunctional dyspepsia is characterised by chronic symptoms of post-prandial distress or epigastric pain not associated with defined structural pathology. Increased peripheral gut-homing T cells have been previously identified in patients. To
Externí odkaz:
https://doaj.org/article/27a57fd705f9440da66c1548f1069a5f