Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Nick, Gilbert"'
Autor:
Catherine Naughton, Covadonga Huidobro, Claudia R. Catacchio, Adam Buckle, Graeme R. Grimes, Ryu-Suke Nozawa, Stefania Purgato, Mariano Rocchi, Nick Gilbert
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
In this study, using a human neocentromere as a model, the authors show that centromeres have a special chromatin structure. Centromere repositioning triggers transcriptional activation, epigenetic remodelling and chromatin fibre decompaction.
Externí odkaz:
https://doaj.org/article/8deef23ccc284ec89e77d8f25e7a8fd1
Autor:
Nick, Gilbert A., Williams, Sharifa, Lekas, Helen-Maria, Pahl, Kerstin, Blau, Chloe, Kamin, Don, Fuller-Lewis, Crystal
Publikováno v:
In Drug and Alcohol Dependence Reports December 2022 5
Autor:
Seraina Blümli, Nicola Wiechens, Meng-Ying Wu, Vijender Singh, Marek Gierlinski, Gabriele Schweikert, Nick Gilbert, Catherine Naughton, Ramasubramanian Sundaramoorthy, Joby Varghese, Robert Gourlay, Renata Soares, David Clark, Tom Owen-Hughes
Publikováno v:
Cell Reports, Vol 37, Iss 5, Pp 109943- (2021)
Summary: The ARID1A subunit of SWI/SNF chromatin remodeling complexes is a potent tumor suppressor. Here, a degron is applied to detect rapid loss of chromatin accessibility at thousands of loci where ARID1A acts to generate accessible minidomains of
Externí odkaz:
https://doaj.org/article/04921146582c4b71a0ec2443dd1ee13e
Autor:
Martin A M Reijns, Louise Thompson, Juan Carlos Acosta, Holly A Black, Francisco J Sanchez-Luque, Austin Diamond, David A Parry, Alison Daniels, Marie O'Shea, Carolina Uggenti, Maria C Sanchez, Alan O'Callaghan, Michelle L L McNab, Martyna Adamowicz, Elias T Friman, Toby Hurd, Edward J Jarman, Frederic Li Mow Chee, Jacqueline K Rainger, Marion Walker, Camilla Drake, Dasa Longman, Christine Mordstein, Sophie J Warlow, Stewart McKay, Louise Slater, Morad Ansari, Ian P M Tomlinson, David Moore, Nadine Wilkinson, Jill Shepherd, Kate Templeton, Ingolfur Johannessen, Christine Tait-Burkard, Jürgen G Haas, Nick Gilbert, Ian R Adams, Andrew P Jackson
Publikováno v:
PLoS Biology, Vol 18, Iss 12, p e3001030 (2020)
With the ongoing COVID-19 (Coronavirus Disease 2019) pandemic, caused by the novel coronavirus SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2), there is a need for sensitive, specific, and affordable diagnostic tests to identify infected
Externí odkaz:
https://doaj.org/article/cd5310c0965d4b4f882567dc2bff3e3b
Autor:
Lotte P Watts, Toyoaki Natsume, Yuichiro Saito, Javier Garzon, Qianqian Dong, Lora Boteva, Nick Gilbert, Masato T Kanemaki, Shin-ichiro Hiraga, Anne D Donaldson
Publikováno v:
eLife, Vol 9 (2020)
Human cells lacking RIF1 are highly sensitive to replication inhibitors, but the reasons for this sensitivity have been enigmatic. Here, we show that RIF1 must be present both during replication stress and in the ensuing recovery period to promote ce
Externí odkaz:
https://doaj.org/article/4e274fe058da4f1c8af7916878a21618
Autor:
Lora Boteva, Ryu-Suke Nozawa, Catherine Naughton, Kumiko Samejima, William C. Earnshaw, Nick Gilbert
Publikováno v:
Cell Reports, Vol 32, Iss 12, Pp 108177- (2020)
Summary: Cells coordinate interphase-to-mitosis transition, but recurrent cytogenetic lesions appear at common fragile sites (CFSs), termed CFS expression, in a tissue-specific manner after replication stress, marking regions of instability in cancer
Externí odkaz:
https://doaj.org/article/bd191e3aabbf4a60bf450f5a8d71b639
Akademický článek
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Publikováno v:
Current Opinion in Genetics & Development. 72:38-44
Scaffold attachment factor A (SAF-A) or hnRNP U is a nuclear RNA-binding protein with a well-documented role in processing newly transcribed RNA. Recent studies also indicate that SAF-A can oligomerise in an ATP-dependent manner and interact with RNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab5b19778eb5925a1221a778437c7158
https://doi.org/10.1016/j.gde.2021.10.008
https://doi.org/10.1016/j.gde.2021.10.008
SUMMARYEukaryotic chromosomes compact during mitosis and meiosis into elongated cylinders – and not the spherical globules expected of self-attracting long flexible polymers. This process is mainly driven by condensin-like proteins. Here, we presen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48fdd3187d308c025941588135927ad0
https://doi.org/10.1101/2022.09.27.509716
https://doi.org/10.1101/2022.09.27.509716
Autor:
Marina C. Nocente, Anida Mesihovic Karamitsos, Emilie Drouineau, Waad Albawardi, Cécile Dulary, Florence Ribierre, Hélène Picaud, Olivier Alibert, Joël Acker, Jean-Christophe Aude, Nick Gilbert, Françoise Ochsenbein, Sophie Chantalat, Matthieu Gérard
BRG1, the catalytic subunit of the mammalian SWI/SNF complexes, is essential for chromatin opening at enhancers. However, the nature of the open chromatin remains unclear. Here we show that in addition to producing histone-free DNA, BRG1 generates he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5563f1d687d0597593393ff6cecfcc34
https://doi.org/10.1101/2022.09.15.507958
https://doi.org/10.1101/2022.09.15.507958