Zobrazeno 1 - 10
of 123
pro vyhledávání: '"Nick, Bown"'
Autor:
Erhan Aptullahoglu, Jonathan P. Wallis, Helen Marr, Scott Marshall, Nick Bown, Elaine Willmore, John Lunec
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 14, p 11335 (2023)
Chronic lymphocytic leukemia (CLL) is a genetically and clinically heterogeneous malignancy affecting older individuals. There are a number of current treatment options for CLL, including monoclonal antibodies, targeted drugs, chemotherapy, and diffe
Externí odkaz:
https://doaj.org/article/996f7e0a42974ae6920e29d3628f2072
Autor:
Erhan Aptullahoglu, Carmela Ciardullo, Jonathan P. Wallis, Helen Marr, Scott Marshall, Nick Bown, Elaine Willmore, John Lunec
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2410 (2023)
Several molecular subtypes of cancer are highly dependent on splicing for cell survival. There is a general interest in the therapeutic targeting of splicing by small molecules. E7107, a first-in-class spliceosome inhibitor, showed strong growth inhi
Externí odkaz:
https://doaj.org/article/6f9040da79ba4efb994e204cb3e28ff1
Autor:
Miriam Franklin, Lucy Gentles, Elizabeth Matheson, Nick Bown, Paul Cross, Angela Ralte, Connor Gilkes‐Immeson, Alice Bradbury, Maryam Zanjirband, John Lunec, Yvette Drew, Rachel O'Donnell, Nicola J. Curtin
Publikováno v:
Cancer Medicine, Vol 7, Iss 9, Pp 4744-4754 (2018)
Abstract NUCOLL43 is a novel ovarian clear cell carcinoma (O‐CCC) cell line that arose from a primary culture of a patient's malignant ascites. The cells grow reliably in cell culture with a doubling time of approx. 45 hours and form colonies at hi
Externí odkaz:
https://doaj.org/article/cee3c4c7a6c049d1a597408b8c970ebc
Autor:
Carmela Ciardullo, Erhan Aptullahoglu, Laura Woodhouse, Wei-Yu Lin, Jonathan P Wallis, Helen Marr, Scott Marshall, Nick Bown, Elaine Willmore, John Lunec
Publikováno v:
Haematologica, Vol 104, Iss 12 (2019)
Chronic lymphocytic leukemia (CLL) is a clinically heterogeneous hematologic malignancy. In approximately 90% of cases the TP53 gene is in its wildtype state at diagnosis of this malignancy. As mouse double-minute-2 homolog (MDM2) is a primary repres
Externí odkaz:
https://doaj.org/article/7ecccf9c482b45a5821d7071778cdfac
Autor:
Lisa M. Allinson, Aaron Potts, Angharad Goodman, Nick Bown, Matthew Bashton, Dean Thompson, Nermine O. Basta, Alem S. Gabriel, Michael McCorkindale, Antony Ng, Richard J. Q. McNally, Deborah A. Tweddle
Publikováno v:
Genes, Chromosomes and Cancer. 61:747-753
ALK is the most commonly mutated oncogene in neuroblastoma with increased mutation frequency reported at relapse. Here we report the loss of an ALK mutation in two patients at relapse and a paired neuroblastoma cell line at relapse.\ud \ud ALK detect
Autor:
Deborah A. Tweddle, David Jamieson, Nick Bown, Angharad Humphreys, Susan A. Burchill, Jennifer H. Wright, Michael L. Robinson, Alem S. Gabriel, Dermot Murphy, Antony Ng, Guy Makin, Mark Brougham, Hany Gabra, Elizabeth Gavens, Lindi Chen, Swathi Merugu
Purpose:Circulating tumor cells (CTCs) serve as noninvasive tumor biomarkers in many types of cancer. Our aim was to detect CTCs from patients with neuroblastoma for use as predictive and pharmacodynamic biomarkers.Experimental Design:We collected ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30bfe1a6e674bc192c20eeffbdb6ca43
https://doi.org/10.1158/1078-0432.c.6528330.v1
https://doi.org/10.1158/1078-0432.c.6528330.v1
Autor:
Julie A.E. Irving, Andrew G. Hall, Josef Vormoor, Simon Bailey, Nick Bown, Christine J. Harrison, Rosline Hassan, Lynne Minto, Elizabeth Matheson, Marian Case
Deregulation of the RAS-RAF-mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) kinase (MEK)-ERK signaling cascade is often caused by somatic mutations in genes encoding proteins which influence the activity of this pathway a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fee3ab4b4c8826af7c0cd1260b59b67
https://doi.org/10.1158/0008-5472.c.6496418
https://doi.org/10.1158/0008-5472.c.6496418
Autor:
Julie A.E. Irving, Andrew G. Hall, Josef Vormoor, Simon Bailey, Nick Bown, Christine J. Harrison, Rosline Hassan, Lynne Minto, Elizabeth Matheson, Marian Case
Supplementary Table 3 from Mutation of Genes Affecting the RAS Pathway Is Common in Childhood Acute Lymphoblastic Leukemia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b0aa6e342e03848258b0e226641a1f9
https://doi.org/10.1158/0008-5472.22370486
https://doi.org/10.1158/0008-5472.22370486
Autor:
Julie A.E. Irving, Andrew G. Hall, Josef Vormoor, Simon Bailey, Nick Bown, Christine J. Harrison, Rosline Hassan, Lynne Minto, Elizabeth Matheson, Marian Case
Supplementary Table 2 from Mutation of Genes Affecting the RAS Pathway Is Common in Childhood Acute Lymphoblastic Leukemia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0da64287d43e2de90fbb17df16c0dfed
https://doi.org/10.1158/0008-5472.22370489.v1
https://doi.org/10.1158/0008-5472.22370489.v1
Autor:
Julie A.E. Irving, Andrew G. Hall, Josef Vormoor, Simon Bailey, Nick Bown, Christine J. Harrison, Rosline Hassan, Lynne Minto, Elizabeth Matheson, Marian Case
Supplementary Table 1 from Mutation of Genes Affecting the RAS Pathway Is Common in Childhood Acute Lymphoblastic Leukemia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28cbe7ea71ab8a1c5deeecce7b523d4b
https://doi.org/10.1158/0008-5472.22370492.v1
https://doi.org/10.1158/0008-5472.22370492.v1