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Population-based high-throughput toxicity screen of human iPSC-derived cardiomyocytes and neurons.

Autor: Huang CY, Nicholson MW, Wang JY, Ting CY, Tsai MH, Cheng YC, Liu CL, Chan DZH, Lee YC, Hsu CC, Hsu YH, Yang CF, Chang CMC, Ruan SC, Lin PJ, Lin JH, Chen LL, Hsieh ML, Cheng YY, Hsu WT, Lin YL, Chen CH, Hsu YH, Wu YT, Hacker TA, Wu JC, Kamp TJ, Hsieh PCH

Publikováno v: Cell reports [Cell Rep] 2024 Sep 24; Vol. 43 (9), pp. 114748. Date of Electronic Publication: 2024 Sep 03.

Combined Treatment of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes and Endothelial Cells Regenerate the Infarcted Heart in Mice and Non-Human Primates.

Autor: Cheng YC; Institute of Biomedical Sciences, Academia Sinica, Taiwan (Y.C.C., C.J.L., C.Y.H., C.Y.T., D.Z.H.C., M.W.N., P.J.L., H.C.C., P.C.H.H.)., Hsieh ML; Model Organisms Research Core, Department of Medicine (M.L.H., C.M.C.C., T.A.H.), University of Wisconsin-Madison., Lin CJ; Institute of Biomedical Sciences, Academia Sinica, Taiwan (Y.C.C., C.J.L., C.Y.H., C.Y.T., D.Z.H.C., M.W.N., P.J.L., H.C.C., P.C.H.H.)., Chang CMC; Model Organisms Research Core, Department of Medicine (M.L.H., C.M.C.C., T.A.H.), University of Wisconsin-Madison., Huang CY; Institute of Biomedical Sciences, Academia Sinica, Taiwan (Y.C.C., C.J.L., C.Y.H., C.Y.T., D.Z.H.C., M.W.N., P.J.L., H.C.C., P.C.H.H.)., Puntney R; Wisconsin National Primate Research Center (R.P., A.W.M., J.C., P.B., H.A.S.), University of Wisconsin-Madison., Wu Moy A; Wisconsin National Primate Research Center (R.P., A.W.M., J.C., P.B., H.A.S.), University of Wisconsin-Madison., Ting CY; Institute of Biomedical Sciences, Academia Sinica, Taiwan (Y.C.C., C.J.L., C.Y.H., C.Y.T., D.Z.H.C., M.W.N., P.J.L., H.C.C., P.C.H.H.)., Herr Chan DZ; Institute of Biomedical Sciences, Academia Sinica, Taiwan (Y.C.C., C.J.L., C.Y.H., C.Y.T., D.Z.H.C., M.W.N., P.J.L., H.C.C., P.C.H.H.)., Nicholson MW; Institute of Biomedical Sciences, Academia Sinica, Taiwan (Y.C.C., C.J.L., C.Y.H., C.Y.T., D.Z.H.C., M.W.N., P.J.L., H.C.C., P.C.H.H.)., Lin PJ; Institute of Biomedical Sciences, Academia Sinica, Taiwan (Y.C.C., C.J.L., C.Y.H., C.Y.T., D.Z.H.C., M.W.N., P.J.L., H.C.C., P.C.H.H.)., Chen HC; Institute of Biomedical Sciences, Academia Sinica, Taiwan (Y.C.C., C.J.L., C.Y.H., C.Y.T., D.Z.H.C., M.W.N., P.J.L., H.C.C., P.C.H.H.)., Kim GC; Department of Medicine and Stem Cell and Regenerative Medicine Center (G.C.K., J.Z., T.J.K., P.C.H.H.), University of Wisconsin-Madison., Zhang J; Department of Medicine and Stem Cell and Regenerative Medicine Center (G.C.K., J.Z., T.J.K., P.C.H.H.), University of Wisconsin-Madison., Coonen J; Wisconsin National Primate Research Center (R.P., A.W.M., J.C., P.B., H.A.S.), University of Wisconsin-Madison., Basu P; Wisconsin National Primate Research Center (R.P., A.W.M., J.C., P.B., H.A.S.), University of Wisconsin-Madison., Simmons HA; Wisconsin National Primate Research Center (R.P., A.W.M., J.C., P.B., H.A.S.), University of Wisconsin-Madison., Liu YW; Division of Cardiology, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan (Y.W.L.)., Hacker TA; Model Organisms Research Core, Department of Medicine (M.L.H., C.M.C.C., T.A.H.), University of Wisconsin-Madison., Kamp TJ; Department of Medicine and Stem Cell and Regenerative Medicine Center (G.C.K., J.Z., T.J.K., P.C.H.H.), University of Wisconsin-Madison., Hsieh PCH; Institute of Biomedical Sciences, Academia Sinica, Taiwan (Y.C.C., C.J.L., C.Y.H., C.Y.T., D.Z.H.C., M.W.N., P.J.L., H.C.C., P.C.H.H.).; Department of Medicine and Stem Cell and Regenerative Medicine Center (G.C.K., J.Z., T.J.K., P.C.H.H.), University of Wisconsin-Madison.; Institute of Medical Genomics and Proteomics and Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan (P.C.H.H.).

Publikováno v: Circulation [Circulation] 2023 Oct 31; Vol. 148 (18), pp. 1395-1409. Date of Electronic Publication: 2023 Sep 21.

Cardio- and Neurotoxicity of Selected Anti-COVID-19 Drugs.

Autor: Nicholson MW; Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan., Huang CY; Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan., Wang JY; Genomics Research Center, Academia Sinica, Taipei 115, Taiwan., Ting CY; Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan., Cheng YC; Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan., Chan DZH; Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan., Lee YC; Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan., Hsu CC; Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan., Hsu YH; Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan., Chang CMC; Cardiovascular Physiology Core Facility, Department of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA., Hsieh ML; Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan.; Cardiovascular Physiology Core Facility, Department of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA., Cheng YY; Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan., Lin YL; Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan., Chen CH; Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan., Wu YT; Genomics Research Center, Academia Sinica, Taipei 115, Taiwan., Hacker TA; Cardiovascular Physiology Core Facility, Department of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA., Wu JC; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA., Kamp TJ; Department of Medicine and Stem Cell and Regenerative Medicine Center, University of Wisconsin-Madison, Madison, WI 53705, USA., Hsieh PCH; Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan.; Department of Medicine and Stem Cell and Regenerative Medicine Center, University of Wisconsin-Madison, Madison, WI 53705, USA.; Institute of Clinical Medicine, National Taiwan University, Taipei 106, Taiwan.

Publikováno v: Pharmaceuticals (Basel, Switzerland) [Pharmaceuticals (Basel)] 2022 Jun 20; Vol. 15 (6). Date of Electronic Publication: 2022 Jun 20.

Population-based high-throughput toxicity screen of human iPSC-derived cardiomyocytes and neurons.

Autor: Huang CY; Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan., Nicholson MW; Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan., Wang JY; Genomics Research Center, Academia Sinica, Taipei 115, Taiwan., Ting CY; Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan., Tsai MH; Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan., Cheng YC; Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan., Liu CL; Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan., Chan DZH; Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan., Lee YC; Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan., Hsu CC; Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan., Hsu YH; Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan., Yang CF; Institute of Applied Mechanics, National Taiwan University, Taipei 106, Taiwan., Chang CMC; Cardiovascular Physiology Core Facility, Department of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA., Ruan SC; Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan., Lin PJ; Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan., Lin JH; Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan., Chen LL; Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan., Hsieh ML; Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan; Cardiovascular Physiology Core Facility, Department of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA., Cheng YY; Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan., Hsu WT; School of Pharmacy, College of Medicine, National Taiwan University, Taipei 100, Taiwan., Lin YL; Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan., Chen CH; Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan., Hsu YH; Institute of Applied Mechanics, National Taiwan University, Taipei 106, Taiwan., Wu YT; Genomics Research Center, Academia Sinica, Taipei 115, Taiwan., Hacker TA; Cardiovascular Physiology Core Facility, Department of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA., Wu JC; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA., Kamp TJ; Department of Medicine and Stem Cell and Regenerative Medicine Center, University of Wisconsin-Madison, Madison, WI 53705, USA., Hsieh PCH; Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan; Department of Medicine and Stem Cell and Regenerative Medicine Center, University of Wisconsin-Madison, Madison, WI 53705, USA; Institute of Medical Genomics and Proteomics and Institute of Clinical Medicine, National Taiwan University, Taipei 106, Taiwan. Electronic address: phsieh@ibms.sinica.edu.tw.

Publikováno v: Cell reports [Cell Rep] 2022 Apr 05; Vol. 39 (1), pp. 110643.