Hematopoietic cell-restricted deletion of CD36 reduces high-fat diet-induced macrophage infiltration and improves insulin signaling in adipose tissue.

Autor: Nicholls HT, Kowalski G, Kennedy DJ, Risis S, Zaffino LA, Watson N, Kanellakis P, Watt MJ, Bobik A, Bonen A, Febbraio M, Lancaster GI, Febbraio MA, Nicholls, Hayley T, Kowalski, Greg, Kennedy, David J, Risis, Steve, Zaffino, Lee A, Watson, Nadine, Kanellakis, Peter

Publikováno v: Diabetes; Apr2011, Vol. 60 Issue 4, p1100-1110, 11p

Flattening of circadian glucocorticoid oscillations drives acute hyperinsulinemia and adipocyte hypertrophy.

Autor: Tholen S; Department of Chemical and Systems Biology, Stanford University, Stanford, CA 94305, USA., Patel R; Department of Biochemistry and the Gale and Ira Drukier Institute of Children's Health, Weill Cornell Medical College of Cornell University, New York, NY, USA., Agas A; Department of Biochemistry and the Gale and Ira Drukier Institute of Children's Health, Weill Cornell Medical College of Cornell University, New York, NY, USA., Kovary KM; Department of Chemical and Systems Biology, Stanford University, Stanford, CA 94305, USA., Rabiee A; Department of Chemical and Systems Biology, Stanford University, Stanford, CA 94305, USA., Nicholls HT; Weill Center for Metabolic Health, Division of Endocrinology, Diabetes and Metabolism, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medical College of Cornell University, New York, NY, USA., Bielczyk-Maczyńska E; Department of Chemical and Systems Biology, Stanford University, Stanford, CA 94305, USA., Yang W; Department of Chemical and Systems Biology, Stanford University, Stanford, CA 94305, USA., Kraemer FB; Department of Medicine, Division of Endocrinology, Stanford University, Stanford, CA, USA; VA Palo Alto Health Care System, Palo Alto, CA 94305, USA., Teruel MN; Department of Chemical and Systems Biology, Stanford University, Stanford, CA 94305, USA; Department of Bioengineering, Stanford University, Stanford, CA 94305, USA; Department of Biochemistry and the Gale and Ira Drukier Institute of Children's Health, Weill Cornell Medical College of Cornell University, New York, NY, USA; Weill Center for Metabolic Health, Division of Endocrinology, Diabetes and Metabolism, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medical College of Cornell University, New York, NY, USA. Electronic address: mnt4002@med.cornell.edu.

Publikováno v: Cell reports [Cell Rep] 2022 Jun 28; Vol. 39 (13), pp. 111018.

Thioesterase superfamily member 1 undergoes stimulus-coupled conformational reorganization to regulate metabolism in mice.

Autor: Li Y; Division of General Surgery, Department of Surgery, Beth Israel Deaconess Medical Center, Boston, MA, USA.; Department of Surgery, Harvard Medical School, Boston, MA, USA., Imai N; Division of Gastroenterology and Hepatology, Department of Medicine, Weill Cornell Medical College, New York, NY, USA., Nicholls HT; Division of Gastroenterology and Hepatology, Department of Medicine, Weill Cornell Medical College, New York, NY, USA., Roberts BR; Department of Biochemistry, Emory University, Atlanta, GA, USA., Goyal S; Division of General Surgery, Department of Surgery, Beth Israel Deaconess Medical Center, Boston, MA, USA.; Department of Surgery, Harvard Medical School, Boston, MA, USA., Krisko TI; Division of Gastroenterology and Hepatology, Department of Medicine, Weill Cornell Medical College, New York, NY, USA., Ang LH; Division of General Surgery, Department of Surgery, Beth Israel Deaconess Medical Center, Boston, MA, USA.; Department of Surgery, Harvard Medical School, Boston, MA, USA., Tillman MC; Department of Biochemistry, Emory University, Atlanta, GA, USA., Roberts AM; Department of Biochemistry, Emory University, Atlanta, GA, USA., Baqai M; Division of General Surgery, Department of Surgery, Beth Israel Deaconess Medical Center, Boston, MA, USA.; Department of Surgery, Harvard Medical School, Boston, MA, USA., Ortlund EA; Department of Biochemistry, Emory University, Atlanta, GA, USA., Cohen DE; Division of Gastroenterology and Hepatology, Department of Medicine, Weill Cornell Medical College, New York, NY, USA. dcohen@med.cornell.edu., Hagen SJ; Division of General Surgery, Department of Surgery, Beth Israel Deaconess Medical Center, Boston, MA, USA. shagen@bidmc.harvard.edu.; Department of Surgery, Harvard Medical School, Boston, MA, USA. shagen@bidmc.harvard.edu.

Publikováno v: Nature communications [Nat Commun] 2021 Jun 09; Vol. 12 (1), pp. 3493. Date of Electronic Publication: 2021 Jun 09.

CerS6-Derived Sphingolipids Interact with Mff and Promote Mitochondrial Fragmentation in Obesity.

Autor: Hammerschmidt P; Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931 Cologne, Germany; Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), University Hospital Cologne, Kerpener Strasse 26, 50924 Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne., Ostkotte D; Heidelberg University Biochemistry Center, Im Neuenheimer Feld 328, 69120 Heidelberg, Germany., Nolte H; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne; Max Planck Institute for Biology of Ageing, Joseph-Stelzmann-Strasse 9B, 50931 Cologne, Germany., Gerl MJ; Heidelberg University Biochemistry Center, Im Neuenheimer Feld 328, 69120 Heidelberg, Germany; Current address: Lipotype GmbH, Tatzberg 47, 01307 Dresden, Germany., Jais A; Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931 Cologne, Germany; Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), University Hospital Cologne, Kerpener Strasse 26, 50924 Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne., Brunner HL; Heidelberg University Biochemistry Center, Im Neuenheimer Feld 328, 69120 Heidelberg, Germany., Sprenger HG; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne; Max Planck Institute for Biology of Ageing, Joseph-Stelzmann-Strasse 9B, 50931 Cologne, Germany., Awazawa M; Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931 Cologne, Germany; Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), University Hospital Cologne, Kerpener Strasse 26, 50924 Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne., Nicholls HT; Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931 Cologne, Germany; Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), University Hospital Cologne, Kerpener Strasse 26, 50924 Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne., Turpin-Nolan SM; Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931 Cologne, Germany; Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), University Hospital Cologne, Kerpener Strasse 26, 50924 Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne., Langer T; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne; Max Planck Institute for Biology of Ageing, Joseph-Stelzmann-Strasse 9B, 50931 Cologne, Germany., Krüger M; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne., Brügger B; Heidelberg University Biochemistry Center, Im Neuenheimer Feld 328, 69120 Heidelberg, Germany., Brüning JC; Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931 Cologne, Germany; Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), University Hospital Cologne, Kerpener Strasse 26, 50924 Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne; National Center for Diabetes Research (DZD), Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany. Electronic address: bruening@sf.mpg.de.

Publikováno v: Cell [Cell] 2019 May 30; Vol. 177 (6), pp. 1536-1552.e23.

Hepatology Highlights.

Autor: Russo N, Brown RS Jr; Division of Gastroenterology & Hepatology, Weill Cornell Medical College, New York, NY., Shah SL, Krisko TI; Division of Gastroenterology & Hepatology, Weill Cornell Medical College, New York, NY., Krumm CS, Nicholls HT; Division of Gastroenterology & Hepatology, Weill Cornell Medical College, New York, NY., Mousa O, Malhi H; Mayo Clinic, Rochester, MN., Schwartz RE; Division of Gastroenterology & Hepatology, Weill Cornell Medical College, New York, NY., Lominadze Z, Rosenblatt R, Fortune BE; Division of Gastroenterology & Hepatology, Weill Cornell Medical College, New York, NY., Pisa JF, Jesudian AB; Division of Gastroenterology & Hepatology, Weill Cornell Medical College, New York, NY., Gupta V, Tafesh ZH

Publikováno v: Hepatology (Baltimore, Md.) [Hepatology] 2019 Feb; Vol. 69 (2), pp. 469-472.