Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Nichole Welch"'
Autor:
Alfredo Ornelas, Nichole Welch, Jacob A. Countess, Liheng Zhou, Ruth X. Wang, Alexander S. Dowdell, Sean P. Colgan
Publikováno v:
Gut Microbes, Vol 15, Iss 2 (2023)
ABSTRACTMicrobiota-derived short-chain fatty acids, including butyrate (BA), have multiple beneficial health effects. In the colon, BA concentrations range from 10 to 20 mM and up to 95% is utilized as energy by the mucosa. BA plays a key role in epi
Externí odkaz:
https://doaj.org/article/3b8e7601f3014983aafa15618abcb3ef
Autor:
Calen A. Steiner, Samuel D. Koch, Tamara Evanoff, Nichole Welch, Rachael Kostelecky, Rosemary Callahan, Emily M. Murphy, Tom T. Nguyen, Caroline H.T. Hall, Sizhao Lu, Edwin F. de Zoeten, Mary C.M. Weiser-Evans, Ian M. Cartwright, Sean P. Colgan
Publikováno v:
The American Journal of Pathology.
Butyrate Analogues Mimicking Hypoxia by the Chemical Stabilization of Hypoxia Inducible Factor (HIF)
Publikováno v:
The FASEB Journal. 36
Autor:
Alexander S. Dowdell, David A. Kitzenberg, Rachael E. Kostelecky, Omemh Mahjoob, Nichole Welch, Louise E. Glover, Sean P. Colgan
Publikováno v:
The FASEB Journal. 36
Autor:
Ian M Cartwright, Alexander S Dowdell, Camila Hanson, Rachael E Kostelecky, Nichole Welch, Calen A Steiner, Sean P Colgan
Publikováno v:
J Leukoc Biol
Neutrophil (PMN) infiltration during active inflammation imprints changes in the local tissue environment. Such responses are often accompanied by significant extracellular acidosis that result in predictable transcriptional responses. In this study,
Autor:
Alexander S. Dowdell, Ian M. Cartwright, David A. Kitzenberg, Rachael E. Kostelecky, Omemh Mahjoob, Bejan J. Saeedi, Nichole Welch, Louise E. Glover, Sean P. Colgan
Publikováno v:
Cell reports. 40(13)
The intestinal mucosa exists in a state of "physiologic hypoxia," where oxygen tensions are markedly lower than those in other tissues. Intestinal epithelial cells (IECs) have evolved to maintain homeostasis in this austere environment through oxygen
Autor:
Jordi M. Lanis, Ian M. Cartwright, Nichole Welch, Kathryn R. Brink, Jeffrey J. Tabor, Andrew Mu, Rachael Kostelecky, Caroline H. T. Hall, Alexander S. Dowdell, Mark E. Gerich, Sean P. Colgan, Joseph C. Onyiah, Rachel E. M. Schaefer
Publikováno v:
Proc Natl Acad Sci U S A
Metabolic changes associated with tissue inflammation result in significant extracellular acidosis (EA). Within mucosal tissues, intestinal epithelial cells (IEC) have evolved adaptive strategies to cope with EA through the up-regulation of SLC26A3 t
Autor:
Rachael Kostelecky, Jeffrey J. Tabor, Kathryn R. Brink, Ian M. Cartwright, Andrew Mu, Mark E. Gerich, Nichole Welch, Alexander S. Dowdell, Joseph C. Onyiah, Jordi M. Lanis, Caroline H. T. Hall, Sean P. Colgan, Rachel E. M. Schaefer
Publikováno v:
The FASEB Journal. 35
Autor:
Jordi M. Lanis, Ruth Wang, Sean P. Colgan, Nichole Welch, Daniel J. Kao, Matthew S Goldberg, Ian M. Cartwright, Valerie F. Curtis, Krista M. Burney, J. Scott Lee, Caroline H. T. Hall, Eric L. Campbell
Publikováno v:
Molecular Biology of the Cell
Extracellular adenosine signaling is established as a protective component in mucosal inflammatory responses. The sources of extracellular adenosine include enzymatic processing from nucleotides, such as ATP and AMP, that can be liberated from a vari
Autor:
Matthew S Goldberg, Louis E. Glover, Ian M. Cartwright, Tyler Ross, Rachael Kostelecky, Nichole Welch, Alexander S. Dowdell, Sean P. Colgan
Publikováno v:
Molecular Biology of the Cell
Intestinal epithelial cells (IECs) exist in a metabolic state of low oxygen tension termed "physiologic hypoxia." An important factor in maintaining intestinal homeostasis is the transcription factor hypoxia-inducible factor (HIF), which is stabilize