Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Nichole M Helton"'
Autor:
Ling Tian, Monique Chavez, Gue Su Chang, Nichole M Helton, Casey D S Katerndahl, Christopher A Miller, Lukas D Wartman
Publikováno v:
PLoS ONE, Vol 16, Iss 11, p e0255706 (2021)
Kdm6a/Utx, a gene on the X chromosome, encodes a histone H3K27me3 demethylase that has an orthologue on the Y chromosome (Uty) (Zheng et al. 2018). We previously identified inactivating mutations of Kdm6a in approximately 50% of mouse acute promyeloc
Externí odkaz:
https://doaj.org/article/d68f9532a3ca4ebc94b2933b4344ed73
Autor:
Cheng Li, Jeffery M Klco, Nichole M Helton, Daniel R George, Jacqueline L Mudd, Christopher A Miller, Charles Lu, Robert Fulton, Michelle O'Laughlin, Catrina Fronick, Richard K Wilson, Timothy J Ley
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0120585 (2015)
Induced pluripotent stem cells (iPSCs) have tremendous potential as a tool for disease modeling, drug testing, and other applications. Since the generation of iPSCs "captures" the genetic history of the individual cell that was reprogrammed, iPSC clo
Externí odkaz:
https://doaj.org/article/73ab1f5c417840cfa7d34a0d43a26d9f
Autor:
Haley J. Abel, Karolyn A. Oetjen, Christopher A. Miller, Sai M. Ramakrishnan, Ryan B. Day, Nichole M. Helton, Catrina C. Fronick, Robert S. Fulton, Sharon E. Heath, Stefan P. Tarnawsky, Sridhar Nonavinkere Srivatsan, Eric J. Duncavage, Molly C. Schroeder, Jacqueline E. Payton, David H. Spencer, Matthew J. Walter, Peter Westervelt, John F. DiPersio, Timothy J. Ley, Daniel C. Link
Publikováno v:
medRxiv
TP53-mutated myeloid malignancies are most frequently associated with complex cytogenetics. The presence of complex and extensive structural variants complicates detailed genomic analysis by conventional clinical techniques. We performed whole genome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a44e327723fe5a17b6464bb984b726e7
Autor:
Michelle A Cai, Timothy J. Ley, Lukas D. Wartman, Sridhar Nonavinkere Srivatsan, Timothy P Rooney, Sai Mukund Ramakrishnan, Christopher A. Miller, Nichole M. Helton, Casey D.S. Katerndahl, Ryan B. Day, Olivia R S Rogers, Mieke Hoock
Publikováno v:
Blood
Most patients with acute promyelocytic leukemia (APL) can be cured with combined all-trans retinoic acid (ATRA) and arsenic trioxide therapy, which induces the destruction of PML-RARA, the initiating fusion protein for this disease. However, the unde
Autor:
Nancy Arthur, Keegan A Christensen, Kathleen Mannino, Stephen M. Sykes, Ashutosh Kumar, Nichole M Helton, Agata Gruszczynska, Timothy J Ley, Francesca Ferraro
Publikováno v:
Blood. 140:2960-2961
Autor:
Casey D.S. Katerndahl, Olivia R.S. Rogers, Sai Mukund Ramakrishnan, Christopher A Miller, Nichole M Helton, Mieke Hoock, Timothy J Ley
Publikováno v:
Blood. 140:5858-5859
Autor:
Sidan Li, Juo-Chin Yao, Karolyn A. Oetjen, Joseph R. Krambs, Jun Xia, Jingzhu Zhang, Amy P. Schmidt, Nichole M. Helton, Robert S. Fulton, Sharon E. Heath, Isaiah R. Turnbull, Gabriel Mbalaviele, Timothy J. Ley, Matthew J. Walter, Daniel C. Link
Publikováno v:
Blood. 140(14)
Hematopoietic stem/progenitor cells (HSPCs) reside in localized microenvironments, or niches, in the bone marrow that provide key signals regulating their activity. A fundamental property of hematopoiesis is the ability to respond to environmental cu
Autor:
Michael H. Kramer, Qiang Zhang, Robert Sprung, Ryan B. Day, Petra Erdmann-Gilmore, Yang Li, Ziheng Xu, Nichole M. Helton, Daniel R. George, Yiling Mi, Peter Westervelt, Jacqueline E. Payton, Sai M. Ramakrishnan, Christopher A. Miller, Daniel C. Link, John F. DiPersio, Matthew J. Walter, R. Reid Townsend, Timothy J. Ley
Publikováno v:
Blood. 140(13)
We have developed a deep-scale proteome and phosphoproteome database from 44 representative acute myeloid leukemia (AML) patients from the LAML TCGA dataset and 6 healthy bone marrow–derived controls. After confirming data quality, we orthogonally
Autor:
Mieke Hoock, Catrina Fronick, Gue Su Chang, Angela M. Verdoni, David H. Spencer, Elizabeth R. Leight, Robert S. Fulton, Celia V. Bangert, Christopher A. Miller, Meryl K. Brune, Nichole M. Helton, Timothy J. Ley, Amanda Smith, Daniel R. George, David Y. Chen, Sai Mukund Ramakrishnan, Shamika Ketkar, Allegra A. Petti
Publikováno v:
Proceedings of the National Academy of Sciences. 117:3123-3134
Mutations in the DNA methyltransferase 3A ( DNMT3A ) gene are the most common cause of age-related clonal hematopoiesis (ARCH) in older individuals, and are among the most common initiating events for acute myeloid leukemia (AML). The most frequent D
Autor:
Francesca Ferraro, Jacqueline E. Payton, Keegan A. Christensen, Lukas D. Wartman, Ann-Kathrin Eisfeld, Sai Mukund Ramakrishnan, Ryan B. Day, Matthew J. Christopher, Geoffrey L. Uy, Michael P. Rettig, Peter Westervelt, Matthew J. Schuelke, Catrina Fronick, Robert S. Fulton, Jack Baty, Clara D. Bloomfield, David H. Spencer, Timothy J. Ley, Christopher A. Miller, Margaret O’Laughlin, Sharon Heath, Jessica Kohlschmidt, Nichole M. Helton, John F. DiPersio, Matthew J. Walter, John S. Welch, Daniel C. Link
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Current acute myeloid leukemia (AML) risk assessment relies on cytogenetics and gene-sequencing studies but is imperfect, especially for patients with normal karyotypes and intermediate risk. To understand factors associated with excelle