Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Nichole M Danzl"'
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e86129 (2014)
Thymic epithelial cells (TECs) are critical for the normal development and function of the thymus. Here, we examined the developmental stages of TECs using quantitative assessment of the cortical and medullary markers Keratin 5 and Keratin 8 (K5 and
Externí odkaz:
https://doaj.org/article/7e86550e9f8b47e68d82d3005d3114eb
Autor:
Chiara Borsotti, Nichole M. Danzl, Grace Nauman, Markus A. Hölzl, Clare French, Estefania Chavez, Mohsen Khosravi-Maharlooei, Salome Glauzy, Fabien R. Delmotte, Eric Meffre, David G. Savage, Sean R. Campbell, Robin Goland, Ellen Greenberg, Jing Bi, Prakash Satwani, Suxiao Yang, Joan Bathon, Robert Winchester, Megan Sykes
Publikováno v:
Blood Advances, Vol 1, Iss 23, Pp 2007-2018 (2017)
Abstract: B cells play a major role in antigen presentation and antibody production in the development of autoimmune diseases, and some of these diseases disproportionally occur in females. Moreover, immune responses tend to be stronger in female vs
Externí odkaz:
https://doaj.org/article/72da05736802495ebfbfad73ddbd936c
Autor:
Grace Nauman, Nichole M. Danzl, Jaeyop Lee, Chiara Borsotti, Rachel Madley, Jianing Fu, Markus A. Hölzl, Alexander Dahmani, Akaitz Dorronsoro Gonzalez, Éstefania Chavez, Sean R. Campbell, Suxiao Yang, Prakash Satwani, Kang Liu, Megan Sykes
Publikováno v:
J Immunol
Immunodeficient mice reconstituted with immune systems from patients, or personalized immune (PI) mice, are powerful tools for understanding human disease. Compared with immunodeficient mice transplanted with human fetal thymus tissue and fetal liver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::282f8e47205b9556e7491bb7e8826e16
https://doi.org/10.4049/jimmunol.2100966
https://doi.org/10.4049/jimmunol.2100966
Autor:
Thomas Savage, Peter Liou, Suxiao Yang, Adam Griesemer, Eline T. Luning Prak, Kristjana Frangaj, Megan Sykes, Mercedes Martinez, Wenzhao Meng, Kortney Rogers, Yufeng Shen, Wang Z, Julien Zuber, Jianing Fu, Alina Iuga, Aaron M. Rosenfeld, Brittany Shonts, Tomoaki Kato, Aleksandar Obradovic, Elizabeth E. Waffarn, Sai-Ping Lau, Nichole M. Danzl, Shilpa Ravella, Siu-hong Ho, Prakash Satwani
Publikováno v:
J Clin Invest
In humans receiving intestinal transplantation (ITx), long-term multilineage blood chimerism often develops. Donor T cell macrochimerism (≥4%) frequently occurs without graft-versus-host disease (GVHD) and is associated with reduced rejection. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d20a084a0b36b525241366fcdd33ba1
https://europepmc.org/articles/PMC8062082/
https://europepmc.org/articles/PMC8062082/
Autor:
Megan Sykes, Nichole M. Danzl, Chiara Borsotti, Maki Nakayama, Mohsen Khosravi Maharlooei, Grace Nauman, Hao Wei Li, Rachel Madley, Bart O. Roep, Estefania Chavez, Remi J. Creusot
Publikováno v:
Journal of Translational Autoimmunity
Journal of Translational Autoimmunity, Vol 3, Iss, Pp 100061-(2020)
Journal of Translational Autoimmunity, Vol 3, Iss, Pp 100061-(2020)
During T cell development in mice, thymic negative selection deletes cells with the potential to recognize and react to self-antigens. In human T cell-dependent autoimmune diseases such as Type 1 diabetes, multiple sclerosis, and rheumatoid arthritis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e183023d973401fe2ae9fa173994ce7f
http://europepmc.org/articles/PMC7451786
http://europepmc.org/articles/PMC7451786
Autor:
Nichole M. Danzl, Megan Sykes, Maki Nakayama, Bart O. Roep, Yang Li, Yong-Guang Yang, Grace Nauman, Mohsen Khosravi Maharlooei, Gaby Duinkerken, Yuying Li, Jinxing Xia, Zheng Hu, Shulian Tan, Estefania Chavez, Chunhui Jin
Publikováno v:
Proceedings of the National Academy of Sciences, 114(41), 10954-10959
There is an urgent and unmet need for humanized in vivo models of type 1 diabetes to study immunopathogenesis and immunotherapy, and in particular antigen-specific therapy. Transfer of patient blood lymphocytes to immunodeficient mice is associated w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38f580c55869947ee17c1cae315c2c94
https://doi.org/10.1073/pnas.1710415114
https://doi.org/10.1073/pnas.1710415114
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 10 (2019)
Frontiers in Immunology, Vol 10 (2019)
Hemophagocytic lymphohistiocytosis (HLH) has recently been increasingly reported as an important complication after stem cell transplantation, in line with the increase in the number of HLA-mismatched transplantation. Although previous clinical studi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8502b78a6e02daff33b00dc513a2957
https://doi.org/10.3389/fimmu.2019.00186
https://doi.org/10.3389/fimmu.2019.00186
Autor:
Nichole M. Danzl, Dustin J. Carpenter, Beth Schrope, Andrew X. Chen, Yvonne M. Saenger, Michael Chait, Robyn D. Gartrell-Corrado, Wei Liu, Stuart P. Weisberg, Pranay Dogra, Pooja Saraf, Donna L. Farber, Xiaojuan Chen, Sean R. Campbell, Mark E. Snyder, Masaru Kubota, Raul Rabadan
Publikováno v:
SSRN Electronic Journal.
Non-recirculating tissue resident memory T-cells (TRM) are the predominant T cell subset in diverse tissue sites where they mediate protective immune responses in situ. Here, we reveal a role for TRM in maintaining immune homeostasis in the human pan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12a049aab0b9d40e569607f2b317d6d4
https://doi.org/10.2139/ssrn.3445675
https://doi.org/10.2139/ssrn.3445675
Autor:
Prakash Satwani, Michael O. Finlayson, Erin C. Bush, Hans-Willem Snoeck, Megan Sykes, Larry L. Luchsinger, Nichole M. Danzl, Masayuki Yazawa, Alexandros Strikoudis
Publikováno v:
Cell stem cell. 25(2)
Summary The specific cellular physiology of hematopoietic stem cells (HSCs) is underexplored, and their maintenance in vitro remains challenging. We discovered that culture of HSCs in low calcium increased their maintenance as determined by phenotype
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef944a24837205cb48d7f9600276a422
https://pubmed.ncbi.nlm.nih.gov/31374196
https://pubmed.ncbi.nlm.nih.gov/31374196
Autor:
Megan Sykes, Nichole M. Danzl, Hans-Willem Snoeck, Alexandros Strikoudis, Masayuki Yasawa, Prakesh Satwani, Larry Luchsinger
Publikováno v:
SSRN Electronic Journal.
The specific cellular physiology of hematopoietic stem cells (HSCs) is underexplored and their maintenance in vitro remains challenging. We discovered that culture of HSC in low calcium increased their maintenance as determined by phenotype, function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2643e093a7565200c48340f7256e6e3
https://doi.org/10.2139/ssrn.3231849
https://doi.org/10.2139/ssrn.3231849