Výsledky vyhledávání - "Nichole M, Helton"

Akademický článek

Functional and epigenetic phenotypes of humans and mice with DNMT3A Overgrowth Syndrome

Autor: Amanda M. Smith, Taylor A. LaValle, Marwan Shinawi, Sai M. Ramakrishnan, Haley J. Abel, Cheryl A. Hill, Nicole M. Kirkland, Michael P. Rettig, Nichole M. Helton, Sharon E. Heath, Francesca Ferraro, David Y. Chen, Sangeeta Adak, Clay F. Semenkovich, Diana L. Christian, Jenna R. Martin, Harrison W. Gabel, Christopher A. Miller, Timothy J. Ley

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)

Germline mutations in the DNMT3A gene can cause an overgrowth syndrome associated with behavioural and hematopoietic phenotypes. Here the authors describe a mouse model of this syndrome that recapitulates many of these features, including conserved a

Externí odkaz: https://doaj.org/article/5e0d8e3763324ed0920eb1d6b6fbeadf

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Akademický článek

Kdm6a deficiency restricted to mouse hematopoietic cells causes an age- and sex-dependent myelodysplastic syndrome-like phenotype

Autor: Ling Tian, Monique Chavez, Gue Su Chang, Nichole M. Helton, Casey D. S. Katerndahl, Christopher A. Miller, Lukas D. Wartman

Publikováno v: PLoS ONE, Vol 16, Iss 11 (2021)

Kdm6a/Utx, a gene on the X chromosome, encodes a histone H3K27me3 demethylase that has an orthologue on the Y chromosome (Uty) (Zheng et al. 2018). We previously identified inactivating mutations of Kdm6a in approximately 50% of mouse acute promyeloc

Externí odkaz: https://doaj.org/article/66701aace8f94cd5834da0a895bd2866

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Akademický článek

Cellular stressors contribute to the expansion of hematopoietic clones of varying leukemic potential

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)

Cellular stressors can impact clonal hematopoiesis. Here, the authors explore the impact of cytotoxic therapy and hematopoietic transplantation on clonal expansion, suggesting different stressors can promote expansion of distinct long-lived clones.

Externí odkaz: https://doaj.org/article/a452ad93f9a248dab38fccf1d7384184

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Genomic landscape of TP53-mutated myeloid malignancies

Publikováno v: medRxiv

TP53-mutated myeloid malignancies are most frequently associated with complex cytogenetics. The presence of complex and extensive structural variants complicates detailed genomic analysis by conventional clinical techniques. We performed whole genome

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a44e327723fe5a17b6464bb984b726e7

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Tumor suppressor function of Gata2 in acute promyelocytic leukemia

Autor: Michelle A Cai, Timothy J. Ley, Lukas D. Wartman, Sridhar Nonavinkere Srivatsan, Timothy P Rooney, Sai Mukund Ramakrishnan, Christopher A. Miller, Nichole M. Helton, Casey D.S. Katerndahl, Ryan B. Day, Olivia R S Rogers, Mieke Hoock

Publikováno v: Blood

Most patients with acute promyelocytic leukemia (APL) can be cured with combined all-trans retinoic acid (ATRA) and arsenic trioxide therapy, which induces the destruction of PML-RARA, the initiating fusion protein for this disease. However, the unde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::306784ae5d0e9dd5a117703d7111671f
https://doi.org/10.1182/blood.2021011758

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IL-1β expression in bone marrow dendritic cells is induced by TLR2 agonists and regulates HSC function

Autor: Sidan Li, Juo-Chin Yao, Karolyn A. Oetjen, Joseph R. Krambs, Jun Xia, Jingzhu Zhang, Amy P. Schmidt, Nichole M. Helton, Robert S. Fulton, Sharon E. Heath, Isaiah R. Turnbull, Gabriel Mbalaviele, Timothy J. Ley, Matthew J. Walter, Daniel C. Link

Publikováno v: Blood. 140(14)

Hematopoietic stem/progenitor cells (HSPCs) reside in localized microenvironments, or niches, in the bone marrow that provide key signals regulating their activity. A fundamental property of hematopoiesis is the ability to respond to environmental cu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c94e93d7b5f868453ebbfb8e564a4740
https://pubmed.ncbi.nlm.nih.gov/35675516

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Remethylation of Dnmt3a −/− hematopoietic cells is associated with partial correction of gene dysregulation and reduced myeloid skewing

Autor: Mieke Hoock, Catrina Fronick, Gue Su Chang, Angela M. Verdoni, David H. Spencer, Elizabeth R. Leight, Robert S. Fulton, Celia V. Bangert, Christopher A. Miller, Meryl K. Brune, Nichole M. Helton, Timothy J. Ley, Amanda Smith, Daniel R. George, David Y. Chen, Sai Mukund Ramakrishnan, Shamika Ketkar, Allegra A. Petti

Publikováno v: Proceedings of the National Academy of Sciences. 117:3123-3134

Mutations in the DNA methyltransferase 3A ( DNMT3A ) gene are the most common cause of age-related clonal hematopoiesis (ARCH) in older individuals, and are among the most common initiating events for acute myeloid leukemia (AML). The most frequent D

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a73828fa5a10b09980e27c95b12a85a7
https://doi.org/10.1073/pnas.1918611117

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Proteomic and phosphoproteomic landscapes of acute myeloid leukemia

Autor: Michael H. Kramer, Qiang Zhang, Robert Sprung, Ryan B. Day, Petra Erdmann-Gilmore, Yang Li, Ziheng Xu, Nichole M. Helton, Daniel R. George, Yiling Mi, Peter Westervelt, Jacqueline E. Payton, Sai M. Ramakrishnan, Christopher A. Miller, Daniel C. Link, John F. DiPersio, Matthew J. Walter, R. Reid Townsend, Timothy J. Ley

Publikováno v: Blood. 140(13)

We have developed a deep-scale proteome and phosphoproteome database from 44 representative acute myeloid leukemia (AML) patients from the LAML TCGA dataset and 6 healthy bone marrow–derived controls. After confirming data quality, we orthogonally

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21fdc9632dc82c3050bc65317be09643
https://pubmed.ncbi.nlm.nih.gov/35895896

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